Abstract
Imatinib mesylate is a potent competitive inhibitor of tyrosine kinase and is used in the management of chronic myeloid leukaemia and gastrointestinal stromal tumours (GIST). Various acute and long-term adverse events have been described following the use of imatinib, but there has not yet been a report of delayed wound disruption. We present a case of GIST developing wound disruption after primary healing during adjuvant imatinib therapy.
References
Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumour. J Clin Oncol. 2003;21(23):4342–9.
Blackstein ME. Risk assessment for tumour recurrence after surgical resection of localized primary gastrointestinal stromal tumour (GIST): North America intergroup phase III trial ACOSOG Z9001 [abstract]. In: ASCO gastrointestinal cancers symposium; 2010.
Dematteo RP, Ballman KV, Antonescu CR, et al. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet. 2009;373(9669):1097–104.
National Comprehensive Cancer Network®. Clinical Practice Guidelines in Oncology (NCCN Guidelines®): gastrointestinal stromal tumours (version 3.2012). Fort Washington: National Comprehensive Cancer Network®, Inc.; 2012.
Mughal TI, Schrieber A. Principal long-term adverse effects of imatinib in patients with chronic myeloid leukemia in chronic phase. Biologics. 2010;4:315–23.
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Chauhan, S., Anand, S. A new complication of imatinib: a case report. Drugs Ther Perspect 34, 590–592 (2018). https://doi.org/10.1007/s40267-018-0558-3
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DOI: https://doi.org/10.1007/s40267-018-0558-3