Abstract
Introduction
The price, availability and affordability of drugs used in the prevention and treatment of cardiovascular disease (CVD) when purchased from online pharmacies in China is currently unknown.
Objective
Our objective was to estimate the availability, price and affordability of drugs for the prevention and treatment of CVDs on the basis of information from online pharmacies in China and to provide evidence-based support for improvements to medicine-related policies.
Methods
We estimated the availability, price and affordability of 17 drugs, including their originator brand (OB) and the lowest-priced generic equivalent (LPGE) using the standardized survey method recommended by the World Health Organization and Health Action International. Drug availability was measured as the proportion of online pharmacies providing information on the drug on the day of data collection. We assessed prices by measuring the median price ratio (MPR). Drug affordability was defined as the ratio between the cost of a 30-day supply at the median price and the lowest daily wage of an unskilled government non-technician employee.
Results
The mean availability of OBs and LPGEs from online pharmacies was 47.35 and 70.18 %, and the mean MPR of OBs and LPGEs was 14.7 and 3.4, respectively. In terms of drug affordability, 90 % of OBs had an affordability ratio of >1, whereas 82 % of LPGs had an affordability ratio of <1.
Conclusion
This study provides insight into the availability, price and affordability of 17 drugs for the prevention and treatment of CVDs on the basis of information from 20 online pharmacies in China. Our findings suggest the price of some drugs, especially of OBs, may still be too high. The affordability of OBs is poor, whereas the affordability of most LPGs is good. The government should establish an online payment system and permit patients to pay for online drugs using funds from their healthcare insurance system account. Measures, such as limiting the highest price, should be instituted to regulate the price of OBs. Narrowing the quality gap between OBs and generics is necessary to increase competition. Anti-monopoly laws should be considered to control drug prices.
Similar content being viewed by others
References
World Health Organization. Global status report on non-communicable diseases. Geneva: WHO; 2014.
China National Center for Cardiovascular Disease. Cardiovascular disease report in China. Beijing: NCCD; 2013.
Cardiovascular disease report in China 2014. http://news.medlive.cn/uploadfile/20150808/1439004691237.pdf. Accessed 11 Oct 2016.
Moran A, Gu D, Zhao D, et al. Future cardiovascular disease in China: Markov model and risk factor scenario projections from the coronary heart disease policy model-China. Circ Cardiovasc Qual Outcomes. 2010;3(3):243–52.
Health care financing gaps will reach to 12.2 billion in 2014 in China. Available from: http://www.askci.com/news/201211/29/101820_91.shtml. Accessed 18 Sept 2016.
Zhao YF, Shi FR, Jiang FR, et al. The epidemiological survey and analysis of 14,050 elders above 60 who have hypertension, hypercholesterolemia or diabetes. Shandong Med J. 2009;49(3):89.
Zheng LQ, Li J, Hu DY, et al. An epidemiologic survey about primary risk factors of cardiovascular diseases in rural community of Liaoning Province. Shanxi Med J. 2006;35(12):1065–7.
Mendis S, Abegunde D, Yusuf S, et al. WHO study on prevention of recurrences of myocardial infarction and stroke (WHO-PREMISE). Bull World Health Organ. 2005;83:820–9.
China Food and Drug Administration. Approved online pharmacies. 2015. http://app1.sfda.gov.cn/datasearchface3/base.jsp. Accessed 10 May 2015.
HAI. How the manual was developed. http://www.haiweb.org/medicineprices/manual/development.html. Accessed 11 Oct 2016.
World Health Organization. Model list of essential medicines, 18th edition. 2013. Available from: http://apps.who.int/iris/bitstream/10665/93142/1/EML_18_eng.pdf. Accessed 12 Feb 2015.
World Health Organization/Health Action International (WHO/HAI). Western Pacific Regional Core List. http://www.haiweb.org/medicineprices/updatesMay2008/GlobalRegCoreMedsMay08.pdf. Accessed 23 Sep 2016.
The Ministry of Health in China. National Essential Medicine List (2012 edition). http://www.nhfpc.gov.cn/wsb/pwsyw/201303/f01fcc9623284509953620abc2ab189e.shtml. Accessed 11 Oct 2016.
World Health Organization, Health Action International. Measuring medicine prices, availability, affordability and price components, 2nd edition. 2008. Available from: http://www.haiweb.org/medicineprices/manual/documents.html. Accessed 11 Oct 2016.
Management Sciences for Health in collaboration with the World Health Organization. International Drug Price Indicator Guide. Geneva: WHO; 2011. http://apps.who.int/medicinedocs/documents/s19968en/s19968en.pdf. Accessed 10 May 2015.
Mendis S, Fukino K, Cameron A, et al. The availability and affordability of selected essential medicines for chronic diseases in six low and middle-income countries. Bull World Health Organ. 2007;85:279–88.
World Health Organization. National Medicines List/Formulary/Standard Treatment Guidelines. Geneva: WHO; 2012. http://www.who.int/selection_medicine/country_lists/en/. Accessed 10 May 2015.
Caixin Online. The minimum wage list in China in 2015. Available from: http://special.caixin.com/2012-02-17/100356984.html. Accessed 10 May 2012.
Foreign exchange transactions/purchase and sale contract & online foreign exchange/OANDA. 2015. http://www.oanda.com/lang/cns/. Accessed 20 Jan 2015.
Sun Q. A survey of medicine prices, availability, affordability and price components in Shandong Province. http://haiweb.org/medicineprices/13082013/Shandong_Prov_Report.pdf. Accessed 16 Sept 2016.
Ye L. A survey of medicine prices, availability and affordability in Shanghai, China using the WHO/HAI methodology. 2006. http://haiweb.org/wp-content/uploads/2015/07/China-Shanghai-Report-Pricing-Surveys.pdf. Accessed 19 Sept 2016.
Yang H, Dib HH, Zhu MM, et al. Prices, availability and affordability of essential medicines in rural areas of Hubei Province. China. Health Policy Plan. 2009;25:219–29.
Jiang M, Yang S, Yan K, et al. Measuring access to medicines: a survey of prices, availability and affordability in Shaanxi province of China. PLoS One. 2013;8(8):e70836.
Wang X, Fang Y, Yang S, et al. Access to paediatric essential medicines: a survey of prices, availability, affordability and price components in Shaanxi province, China. PLoS One. 2014;9(3):e90365.
Guan XD, Shi LW. Study on evaluation method for the accessibility of essential medicine in China based on WHO/HAI standardized approach. China Pharm. 2013;24(24):2214.
China’s rural elderly average monthly pension is only 74 Yuan and still need to do farm work. 2012. http://news.sohu.com/20120710/n347817816.shtml. Accessed 26 June 2015.
Aging process quickened in China: more than 14% population are over 60 years older. http://finance.sina.com.cn/china/20140220/114318278925.shtml. Accessed 2 July 2015.
CFDA. Notice on “Measures for the Management, Supervision and Administration of Internet Food and Drugs (exposure draft)”. Available: http://www.sda.gov.cn/WS01/CL0783/100534.html. Accessed 11 Oct 2016.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Funding
No funding was received.
Conflicts of interest
Qingyu Wang, Hongjuan Wang, Yuan Mu, Yan Cheng, Zhongli Gao and Yue Yang have no conflicts of interest.
Rights and permissions
About this article
Cite this article
Wang, Q., Wang, H., Mu, Y. et al. A study on the availability, price and affordability of drugs for preventing and treating cardiovascular diseases based on information from online pharmacies in China. Drugs Ther Perspect 33, 41–46 (2017). https://doi.org/10.1007/s40267-016-0354-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40267-016-0354-x