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The challenges of the loading dose

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References

  1. Bauer LA. Clinical pharmacokinetic and pharmacodynamic concepts. In: Bauer LA, editor. Applied clinical pharmacokinetics, 2nd ed. New York: McGraw-Hill; 2008. p. 15–27.

  2. National Patient Safety Agency. Preventing fatalities from medication loading doses. NPSA/2010/RRR018. London: National Health Service. 2010. http://www.nrls.npsa.nhs.uk/alerts/?entryid45=92305. Accessed 25 Jan 2016.

  3. Summary of product characteristics of the European Medicines Agency (EMA). London: European Medicines Agency. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landing_page.jsp&mid. Accessed 25 Jan 2016.

  4. Summary of product characteristics of the US Food and Drug Administration (FDA). Silver Spring: US Food and Drug Administration (FDA). http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Accessed 25 Jan 2016.

  5. Summary of product characteristics of the Centro de Información online de Medicamentos of the Agencia de Medicamentos y Productos Sanitarios (AEMPS-CIMA). Madrid: Agencia de Medicamentos y Productos Sanitarios (AEMPS). http://www.aemps.gob.es/cima/fichasTecnicas.do?metodo=detalleForm. Accessed 25 Jan 2016.

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Acknowledgments

The authors would like to thank Thomas O’Boyle for editorial assistance.

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Authors and Affiliations

  1. Pharmacy Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), C/ Doctor Esquerdo, 46, 28007, Madrid, Spain

    Paula Arrabal-Durán, Ana de Lorenzo-Pinto, Raquel García-Sánchez & María Sanjurjo-Sáez

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  1. Paula Arrabal-Durán
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  2. Ana de Lorenzo-Pinto
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  3. Raquel García-Sánchez
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  4. María Sanjurjo-Sáez
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Correspondence to Paula Arrabal-Durán.

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Conflict of interest

Arrabal-Durán, P., De Lorenzo-Pinto, A., García-Sánchez, R. and Sanjurjo-Sáez, M. declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required. This article does not contain any studies with human participants or animals performed by any of the authors.

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Arrabal-Durán, P., de Lorenzo-Pinto, A., García-Sánchez, R. et al. The challenges of the loading dose. Drugs Ther Perspect 32, 447–448 (2016). https://doi.org/10.1007/s40267-016-0324-3

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