FormalPara Key Points

The prevalence of atopic dermatitis (AD) in older adults has increased and characteristics of elderly AD have become apparent.

Several factors must be considered when choosing therapies for older patients with AD.

Clinicians should prioritize treatment options that will reduce the burden of disease for older patients with AD.

1 Introduction

Atopic dermatitis (AD) is a chronic, relapsing pruritic skin disease involving allergic inflammation and skin barrier defects in relation to environmental stimuli and the patient’s genetic background [1]. AD is generally considered a pediatric disease with a good prognosis; this condition is known as classic childhood AD, as the onset of AD commonly begins in early infancy or childhood and resolution of AD typically occurs with increasing age until puberty. Although cases of AD either persisting or first appearing in adolescence and young adulthood have also been encountered (referred to as adolescent/adult AD) [2], it was previously considered that the clinical manifestation of patients with adult AD would usually resolve with aging when patients reached their 50 s [2, 3]. Thus, AD has been typically classified into infantile (age < 2 years), childhood (age 2–12 years), and adolescent/adult (> 12 years, but not over middle age) types according to patient age and characteristics of typical skin lesions [3]. However, the paradigm has recently changed. The number of cases of AD remaining or first appearing in adulthood [4, 5], and even in older adults [3, 6], have increased and the characteristics of elderly AD have become apparent [7,8,9,10]. Hence, this newly defined subgroup of elderly AD (age > 60 or ≥ 60 years) was recently added into the classification of AD as a fourth subtype [11, 12]. AD is now considered a lifelong condition in some populations.

With the increasing recognition of AD as a disease that affects older adults [12,13,14,15,16,17,18], it seems appropriate to review the drug treatment options for this condition in the elderly. In this article, treatment options, including topical, oral, and phototherapies as well as biologics, in the management of elderly AD are reviewed. Factors that need to be considered in choosing therapies for older patients with AD are also discussed.

2 Clinical Characteristics of Atopic Dermatitis (AD) in Older Adults

2.1 Clinical Types and Age of Onset of Elderly AD

In general, at least two types of AD have been identified: an immunoglobulin (Ig)E-allergic (extrinsic) type associated with high serum total IgE levels (> 200 or 400 IU/L, according to the standards of the individual facility) and IgE-mediated sensitization to environmental allergens; and a non-IgE-allergic (intrinsic) type with normal serum total IgE levels and a lack of sensitization to environmental allergens [11, 19]. Similar to other age groups, both the IgE-allergic and non-IgE-allergic types of AD occur in elderly AD when the diagnosis of AD is based on standardized diagnostic criteria [13]. In addition, as is the case with infantile AD [20], an indeterminate allergic type also occurs in elderly AD, where the patient has normal serum total IgE levels and positivity for allergen-specific IgEs [6, 8, 11]; this type of AD is an intermediate, vague state between the IgE-allergic and non-IgE-allergic types. In contrast to infantile AD [1, 20], these three clinical phenotypes in elderly AD tend to be present in a discontinuous disease state and might reflect a different pathophysiology [12, 16].

The most common environmental allergens for IgE-allergic elderly AD are house dust mites (HDMs; e.g., Dermatophagoides species), followed by pollens (e.g., grass pollen and Japanese cedar). Positivity rates in two studies were as follows: D. pteronyssinus 72%, D. farinae 70.9%, and grass pollen 68.4% in a Polish study [6]; and D. farinae 83.8% and Japanese cedar 56.8% in the study of our patients [8]. Positivity rates for food, fungus, and animal dander were relatively lower in these studies. Histopathological analyses revealed that as allergens for IgE-associated immediate, late-phase, and delayed-type hypersensitivities, HDMs may be involved in the pathophysiology of skin lesions of IgE-allergic elderly AD [16, 21].

The onset and clinical course of elderly AD are mainly as follows: senile onset (continuous form), senile recurrence with a history of classic childhood AD (outgrowth-recurrence form), and continuation and/or recurrence of adolescent/adult AD (both continuous and outgrowth-recurrence forms with a history of infantile-, childhood-, adolescent-, or adult-onset AD) [1, 8, 12, 16].

2.2 Skin Manifestations

Characteristic manifestations of AD differ according to the period of life. In the infantile phase, erythematous and papulovesicular eruptions, which frequently develop into oozing and crusting, are often observed on the face. In the childhood phase, atopic dry skin and lichenified flexural eczema of the extremities become more prominent. In the adolescent and young adult phases, chronic lichenified eczema on the upper part of the body predominates [3]. Skin manifestations in elderly AD basically match those of adolescent/young adult AD [22], but the reverse sign of lichenified eczema around unaffected folds of the elbows and knees is more common than the classic sign of localized lichenified eczema at those folds [3, 8, 12, 16]. Localized lichenified eczema in the elbow and knee folds is a typical sign of classic childhood AD [23] and adolescent/young adult AD [2] but is uncommon in elderly AD, in which unaffected folds of the elbows and knees are more common [8, 10] and lichenified eczema surrounding the folds, particularly around the elbow folds, is frequently observed in the flexure and extensor sites of the extremities [3, 8]. Other signs of AD such as refractory facial erythema (atopic red face), loss of the lateral eyebrows (Hertoghe sign), Dennie–Morgan infraorbital folds, and neck eczema with reticulate, ripple, or poikilodermic pigmentation (dirty neck) [22] are observed in moderate-to-severe cases. Nummular-form eczema, prurigo-form papules and nodules, and erythrodermic rash may also be observed [12, 16]. In a cross-sectional, population-based study in the United States, it has been demonstrated that, compared with adult AD (18–59 years), clinical manifestations of elderly AD (≥ 60 years) were associated with a significantly lower incidence of active lesions on the face and scalp, marginally significant lower incidence of flexural (including elbow and knee folds) lesions, and significantly higher incidence of lesions on the buttocks or genitals [10].

2.3 Histopathology and Pathophysiology of Skin Lesions

Histopathological evaluation of skin lesions in a patient with elderly AD is often needed for differential diagnosis from other chronic skin diseases such as cutaneous T cell lymphoma. Similar to adult AD, routine hematoxylin–eosin staining in elderly AD shows only non-specific chronic eczematous reactions with epidermal hyperplasia, mononuclear cell infiltration with eosinophils, and increased infiltration of mast cells in the upper dermis in lichenified eczema [3].

By immunohistochemical and molecular analyses, however, AD skin lesions are considered to be T cell-mediated biphasic immune reactions specific to environmental exposures such as allergens. Immune activation of T helper (Th) 2 (i.e., interleukin [IL]-4, IL-5, IL-13, and IL-31), Th22 (i.e., IL-22), and Th17 (i.e., IL-17) cytokines is involved in acute lesions, and progressive activation of Th2 and Th22 cytokines and significant upregulation of Th1 cytokines (i.e., interferon [IFN]-γ) are involved in chronic lesions [24,25,26,27]. Th2 cytokines, i.e., IL-4 and IL-13, stimulate B cells to produce IgE antibodies and promote IgE-induced upregulation of the high-affinity IgE receptor (FcεRI) on mast cells and dendritic cells, and Th2 cytokine IL-5 induces peripheral eosinophil activation. Th2 and Th22 cytokines (i.e., IL-4, IL-13, and IL-22) contribute to the non-genetic impaired expression of skin barrier proteins (e.g., filaggrin) and barrier dysfunction of skin lesions. Th2 cytokine IL-31 is associated with causing itch, and Th22 cytokine IL-22 induces epidermal hyperplasia of chronic lesions in patients with AD [24,25,26,27].

In elderly AD, phenotypic analyses of peripheral blood cytokine concentrations demonstrated the dominance of a Th2 cytokine profile, i.e., IL-4, IL-5, and IL-13, in older patients with IgE-allergic AD, whereas dominance of a Th1 cytokine profile, i.e., IFN-γ, was observed in older patients with AD and low serum total IgE levels [6]. In a recent study on age-specific changes in the molecular phenotype of patients with AD, serum total IgE levels and eosinophil counts were negatively correlated with age in patients with AD, and patients with elderly AD tended to show immune skewing with decreased Th2 and Th22 cytokines and increased Th1 cytokines in lesional skin compared with patients with adult AD [9]. The participation and role of allergen-specific IgEs in the development of skin lesions of AD has been controversial [26], but immunohistopathological analysis in our previous studies indicated that, at least in patients with IgE-allergic elderly AD, IgE-mediated allergic inflammation (composed of IgE-bearing cells, including mast cells, dermal dendritic cells, inflammatory dendritic epidermal cells, and Langerhans cells) accompanied by specific allergens (e.g., HDMs) play a critical role in the features of skin lesions [7, 16, 21].

2.4 Diagnosis of Elderly AD

For clinical diagnosis of elderly AD, lichenified eczema in flexural sites of the extremities is the most important hallmark, although elbow and knee folds tend to be spared in elderly AD. The existence of the pathognomonic clinical signs of AD discussed in Sect. 2.2 may also become a diagnostic hallmark. A personal and/or family history of atopic disorders (e.g., bronchial asthma, allergic rhinoconjunctivitis, and AD) and elevated serum levels of total IgE and allergen-specific IgEs in response to environmental allergens would support the diagnosis. Long-term follow-up (i.e., > 6 months) of the clinical course, analyses of the diagnostic features of AD using standardized criteria (e.g., the Hanifin and Rajka diagnostic criteria [28]), and exclusion of other pruritic skin conditions are thus required to diagnose elderly AD [13]. The main pruritic skin disorders necessitating differentiation from elderly AD, especially from senile-onset or senile-recurrence types of elderly AD, are as follows: asteatotic dermatitis, nummular dermatitis, contact dermatitis, chronic prurigo, adverse drug reactions, scabies, papuloerythroderma of Ofuji [29], and cutaneous T cell lymphoma [30]. However, certain disorders, including non-atopic eczema in the elderly [31], chronic eczematous eruption of aging [32], and senile erythroderma [33, 34], may be characterized by clinical findings similar to elderly AD, and differential diagnosis from elderly AD may be difficult in some cases. Thus, it could be speculated that pruritic skin disorders in the elderly have etiological similarities to elderly AD [12, 17] with regards to the impact of aging on pathogenic factors (e.g., physical skin barrier, innate and adaptive immunity, skin microbiota, and environmental stimuli) that characterize their symptoms and signs. In the near future, a greater understanding of the characteristics of elderly AD as a specific phenotype of AD in old age and clear criteria, including diagnostic biomarkers for definitive diagnosis, will be necessary for patients with elderly AD [11, 17].

2.5 Complications of Coexisting/Underlying Disorders and Malignancy

Most older patients with AD have some complications related to non-allergic coexisting/underlying disorders (e.g., hypertension) that markedly differ from the characteristics of younger age groups of AD. In our hospital, the incidence of coexisting/underlying disorders in cases of IgE-allergic AD was as follows: hypertension 58.3%; heart disease 23.7%; spinal disease 23.7%; cerebrovascular disease 26.3%; diabetes mellitus 18.4%; and chronic renal disease 10.5% [8]. In recent cross-sectional studies in the United States, higher odds of non-allergic complications such as hypertension, heart diseases, diabetes, obesity, anxiety and depression, and autoimmune disease were observed in adult (including older adult) patients with AD than in control subjects [35], and osteoporosis was more frequently found in older patients with AD [36]. In addition, another recent study showed increased cardiovascular and atherosclerosis markers in blood of older patients with AD [18]. In clinical practice, the existence of these coexisting/underlying disorders may place restrictions on treatment options, such as the use of oral corticosteroids and cyclosporine (ciclosporin).

Meanwhile, the incidence of complicating malignancies in older patients with IgE-allergic AD might be lower than that in the general elderly population, although the relationship between AD and malignancy remains controversial [37]. In our retrospective analysis [8], the incidence of malignancy (2.6%, n = 1) among older patients with IgE-allergic AD (n = 38; mean age 76.2 ± 8.7 years) was significantly lower than that (31.9%, n = 23; p < 0.05) in control subjects (older patients with benign epidermal cyst, n = 72; mean age 74.7 ± 7.0 years). Furthermore, older patients with IgE-allergic AD tended to have a lower incidence of mortality from malignancy than control subjects. Although the limitations of retrospective analysis and the small sample size must be considered, these results suggest that the disease state in IgE-allergic elderly AD might involve immunological peculiarities acting against malignancy as a result of over-response against foreign substances, including self-antigens, in which cancer antigens could be involved [12, 16].

3 Management of AD in Older Adults

In the management of older patients with AD, the aforementioned clinical characteristics of elderly AD (Sect. 2) and age-specific factors of patients described in this section must be considered when choosing treatment options, and the following should be evaluated: medical examination, e.g., severity and state of AD, general condition of the patient, past history and complications, and use of conventional drugs; laboratory tests, e.g., presence or absence of serum-specific IgEs and its classification strength against common environmental allergens [3, 8], serum levels of total IgE and thymus and activation-related chemokine (TARC; a biomarker of Th2 cytokine responses) [38], peripheral eosinophil counts, and routine peripheral blood testing for the screening of other latent internal disorders; and clinical examination, e.g., metal patch testing.

Treatment options for older patients with AD are summarized in Table 1.

Table 1 Treatments for atopic dermatitis in older adults

3.1 Basic Treatments

In the treatment of elderly AD, as in other age groups, management of elderly AD comprises treatment to maintain the skin barrier (e.g., moisturizers and emollients), anti-inflammatory measures (e.g., topical corticosteroids, topical calcineurin inhibitors, and adjunctive oral antihistamines/anti-allergic drugs), and the identification and avoidance of exacerbation factors (e.g., environmental allergens) following evaluation of the severity and disease state of patients with AD in accordance with the management guidelines [39,40,41,42,43] and systematic review of treatments [44] for AD. Hence, regular application of moisturizers in combination with topical corticosteroids and calcineurin inhibitors, adjunctive oral antihistamines/anti-allergic drugs, and avoidance of exacerbating factors are the basics of treatment [40] for elderly AD [12, 13, 16].

3.1.1 Avoidance of Exacerbating Factors

Environmental exposures to allergens (e.g., HDMs, pollens, and foods), irritants (e.g., inappropriate clothing, chemicals, and scratching) and pathogens (e.g., Staphylococcus aureus) have been implicated in the pathogenesis of AD [1, 24,25,26,27, 39,40,41,42]. Avoidance of these exacerbating factors (e.g., HDMs [45]) in the living space and lifestyle of patients with AD has been shown to improve AD symptoms [39,40,41,42, 44]. Sweat is one of the exacerbating factors for AD as a source of both allergens [46] and irritants [47]. Hence, washing away sweat by bathing and showering will lead to symptom improvement [39,40,41,42] and are also important for washing away other allergens, irritants, and pathogens on the skin surface. Therefore, therapeutic patient education would be useful in order to avoid exacerbating factors and modify problematic behaviors, such as habitual scratching [43, 44, 48]. In older patients with AD, however, avoidance of these environmental stimuli is not so easy because of their potentially decreased activities of daily living, cognitive function, and self-care ability [12]. For example, older individuals often have fewer baths and generally live in older homes, which have been suggested to have higher levels of HDM allergens, with a corresponding increased risk of exposure and sensitization to the allergens [49,50,51].

3.1.2 Application of Moisturizers

Dry skin (xerosis) is one of the main symptoms of AD and is also a feature of aging skin in older adults (age-related dry skin [senile xerosis]). Moreover, poor lifestyle habits such as excessive washing and showering sometimes worsen dry skin in older adults. Hence, gentle washing with a fully foaming soap is recommended, and rubbing with a towel should be avoided. Several experimental studies indicate that dry skin with an impaired skin barrier may become a cause of inflammation and itching in skin disorders, including AD [52]. Therefore, topical drugs with moisturizing effects should be used as a basic treatment to improve dry skin in patients with elderly AD. Topical moisturizers, e.g., urea or heparinoids, are first-choice drugs [40]. These moisturizers should be applied in combination with topical anti-inflammatory drugs (e.g., topical corticosteroids) immediately after bathing and showering, before the skin is completely dry. Moisturizers should be used on a wide range of skin surfaces, both lesional and non-lesional skin, and use should be continued after the lesion has healed [15].

3.1.3 Topical Corticosteroids

Corticosteroids exert therapeutic effects by inhibiting transcription of several mediators (e.g., cytokines and adhesion molecules) from inflammatory cells in the skin lesion of AD as a result of binding to regulatory elements of many genes via their receptor [53].

Topical corticosteroids are used as a first-line anti-inflammatory treatment for patients with AD and are effective for both active inflammation and disease prophylaxis. Several factors should be considered when choosing a corticosteroid, including potency, drug formulation, severity of skin lesions, and the body area to which the medication will be applied [39,40,41,42]. As a rule, low-potency (medium class or lower) topical corticosteroids should be used for skin lesions on the face and neck where the drug absorption rate is high. High-potency (very-strong class or lower) topical corticosteroids can be used for skin lesions on the body and extremities. However, use of super-potency (strongest) topical corticosteroids should be limited to only refractory lesions such as pruriginous nodules or severe lichenification. Clinicians must always be aware of skin problems (e.g., skin atrophy, telangiectasia, and steroid purpura) associated with the long-term use of topical corticosteroids, especially for older adults with already fragile skin [54]. Concerning the frequency of application, no significant difference was found in the improvement rate between once-daily and more frequent application of topical corticosteroids in several studies [44]. Therefore, the principal guidelines of AD management [39,40,41,42] recommended once- or twice-daily applications of topical corticosteroids in combination with a moisturizer to treat AD-related itch and skin lesions, with reduction in the application frequency or potency of topical corticosteroids when symptoms improve. It has been demonstrated that even low-potency topical corticosteroids can broadly improve immune and barrier responses in patients with moderate-to-severe AD [55]. In older patients, however, topical treatment with the use of multiple external drugs may become difficult because of patients’ lower self-care ability. Therefore, to improve adherence to external treatment in older patients with AD, it is sometimes necessary to prescribe topical corticosteroids and moisturizers as an admixed preparation, although the medicinal properties and stability of the drugs may be somewhat unstable [56].

3.1.4 Topical Calcineurin Inhibitors

Topical calcineurin inhibitors (tacrolimus and pimecrolimus; tacrolimus only in Japan) inhibit cytokine production by T cells via their intracellular calcineurin-inhibiting mechanism, which differs from that of topical corticosteroids. The therapeutic potency of 0.1% tacrolimus ointment is equivalent to topical corticosteroids with intermediate potency (strong class) [39,40,41,42]. Local adverse effects from long-term application of topical corticosteroids in sensitive or thin skin areas can cause atopic red face, dirty neck, skin atrophy, and steroid purpura [13]; however, these are rarely seen with long-term use of topical tacrolimus [39,40,41,42]. Therefore, topical tacrolimus is useful for skin lesions on the face and neck, forearm, and dorsum manus of older patients with AD. Topical tacrolimus is typically applied once daily up to a maximum frequency of twice a day. The most commonly observed adverse effect is irritative symptoms (e.g., transient burning sensation and hot flushes) at the application site during the initial few days after starting treatment [39,40,41,42]. Older patients with AD tend to readily discontinue tacrolimus application because of this adverse effect; therefore, prior explanation of this adverse effect is essential to improve treatment adherence. Irritative symptoms may be reduced by using a small amount of tacrolimus ointment mixed with an emollient (e.g., petrolatum), and the mixture may be useful for the initial period of the treatment. To date, it is considered that application of topical tacrolimus does not appear to increase the risk of skin cancer, lymphoma, or other malignancies with proper usage [39, 42].

3.1.5 Oral Antihistamines/Anti-allergic Drugs

Oral antihistamines (histamine H1-receptor antagonists) are widely used for AD-related itch because several studies support a role of histamine in the pathogenesis of AD [57, 58]. In Japan, many study reports have discussed the positive effects of antihistamines on AD [39, 59, 60]. Conversely, in Europe and the United States, many reports have presented negative opinions [39, 41, 42, 61, 62]. Therefore, oral antihistamines are generally recommended as an adjuvant therapy to topical treatment with anti-inflammatory drugs and moisturizers [39] or as short-term sporadic use in patients with night-time itch [41, 42]. In older patients with AD, however, oral antihistamines may become one of the basic treatments for AD-related itch [40] or are used as adjunctive therapy for topical treatment [59], because older patients usually require systemic anti-pruritic drugs for relief from persistent itch caused by insufficient topical treatment and/or the intractable disease state of AD. In Japanese guidelines for AD management, non-sedative second-generation antihistamines with low anti-cholinergic action are recommended as first-choice agents [39] because they have therapeutic anti-pruritic effects that are similar to those of sedative antihistamines [39, 60]. Additional administration of sedative first-generation antihistamines, which have inhibitory effects on the central nervous system, before bedtime is sometimes useful for older patients with AD who experience sleep disturbance caused by severe night-time itch [40,41,42, 63]. When using oral antihistamines, especially first-generation antihistamines, clinicians must be aware of adverse effects due to their sedative and anti-cholinergic actions, e.g., sleepiness, unsteadiness, impaired performance, urinary retention, and glaucoma.

Combined use of oral antihistamines and anti-allergic drugs without an antihistamine effect may also be effective for itch and related skin lesions in older patients with AD. Disodium cromoglycate, an anti-allergic agent used for food sensitization and/or systemic metal allergy [64, 65], is effective in patients with positivity for specific IgEs to food allergens or metal patch testing [6, 8, 19]. Suplatast tosilate (a Th2 cytokine inhibitor) has a therapeutic effect by inhibiting Th2 cytokine production and decreasing eosinophils at inflammatory sites of skin lesions in patients with raised serum levels of total and specific IgEs and/or TARC [66].

3.2 Additional Treatment Options

The efficacy of basic treatments tends to be inadequate in older patients with AD because avoiding exacerbating factors in the environment and applying sufficient topical medication may become difficult with common geriatric problems and lifestyle changes, e.g., potentially decreased self-care ability with aging and isolation. For older patients, long-term, wide-ranging external treatment becomes a burden of disease. In addition, it has become apparent that moderate-to-severe cases of AD have additional features of systemic inflammation [18] and autoallergy in which T cell-mediated specific immune pathways react not only to environmental allergens but also to self-proteins in the skin as autoantigens [1, 25, 67]. Therefore, for moderate-to-severe cases and/or patients with a lower ability to use topical treatments, powerful anti-inflammatory treatments (e.g., oral corticosteroids, cyclosporine, phototherapy, and biologics) may become necessary as additional treatment options [53, 68].

3.2.1 Oral Corticosteroids

Unlike in childhood/adolescent AD, in which adverse effects such as growth suppression are of concern, oral corticosteroids may be relatively easy to use in cases of elderly AD as an additional therapy to topical corticosteroids. Oral corticosteroids are generally recommended as short-term relief for patients with moderate-to-severe AD by systematic review [69], expert opinion [68, 70], and the guidelines for AD [39,40,41, 43]. However, for the reasons mentioned in Sect. 3.2, they tend to be prescribed at low doses for mid- to long-term use for the treatment of elderly AD. In our retrospective analyses, the usefulness of oral corticosteroids (5–15 mg/day or 0.1–0.2 mg/kg body weight/day in prednisolone-equivalents) in combination with basic treatments was evident in the treatment for elderly AD [8, 12, 16]. In these analyses, oral corticosteroid therapy combined with basic treatments was applied for 27 cases of moderate-to-severe elderly AD (IgE-allergic AD, n = 16; indeterminate-allergic AD, n = 6; non-IgE-allergic AD, n = 5), and the mean ± standard deviation Objective Severity Scoring of Atopic Dermatitis for each clinical type was 41.6 ± 19.1, 22.5 ± 8.0, and 37.7 ± 21.7, respectively. Using a mean (± standard deviation) dosage of oral corticosteroids of 7.7 ± 4.1 mg/day (8.6 ± 4.1, 5.0 ± 3.1, and 7.5 ± 1.8 mg/day in prednisolone-equivalents for each clinical type, respectively), the prognosis of these cases for a duration of 6 months or more was observed to be clinical improvement, defined as disappearance of skin lesions in > 95% of lesional areas with combined therapy at a dosage of oral corticosteroids of ≤  5  mg/day prednisolone-equivalents, in 68.8% of IgE-allergic AD, 100% of indeterminate-allergic AD, and 80% of non-IgE-allergic AD cases. Furthermore, clinical remission, defined as the same disappearance of skin lesions even after discontinuation of oral corticosteroids, was also observed in 18.8% of IgE-allergic AD, 50% of indeterminate-allergic AD, and 40% of non-IgE-allergic AD cases [8]. Although the evidence level of our observational study was very low, oral corticosteroid therapy with basic treatments may become an effective treatment option for elderly AD.

However, there are some important notes for the usage of oral corticosteroid therapy. It should be used in combination with appropriate basic treatments and sufficient evaluation of exacerbating factors and the state of patients with AD. The dosage should be decreased as symptoms improve, and appropriate monitoring and prevention of adverse events such as hypertension, peptic ulcer disease, cataract, osteoporosis, diabetes, infections, adrenal function suppression, and steroid purpura are needed. Working knowledge of the adverse effects of oral corticosteroids is necessary and precautions are required. For example, oral betamethasone 0.5 mg/day (almost equal potency to prednisolone 4.2 mg/day [71]) has a risk of adrenal suppression equivalent to external use of a super-potency (strongest) topical corticosteroid, i.e., 0.05% clobetasol 17-propionate ointment in quantity of 10 g/day [72, 73]. In addition, mid- to long-term use (≥ 3 months) of oral corticosteroids as > 2.5 mg/day prednisolone-equivalents may increase the risk of fracture [74, 75]; hence, preventive administration of bisphosphonates or an active vitamin D3 analog for corticosteroid-induced osteoporosis is needed in these patients [75]. To prevent hepatitis B (HB) virus reactivation during immunosuppressive drug therapy including oral corticosteroids, blood screening for HB surface antigen (HBsAg) and antibody to HB core antigen (anti-HBcAb) should be carried out, and patients with positive results for HBsAg and/or anti-HBcAb must be treated with preventive measures based on the guidelines for hepatic disorders [76]. Vascular strengthening drugs such as vitamin C preparation [77] and ‎carbazochrome sodium [78] may be useful for the treatment of steroid purpura, which may be more likely to occur in older patients with AD as it is a similar condition to senile purpura [79].

3.2.2 Oral Cyclosporine

Cyclosporine inhibits T cell-dependent cytokine products and immune pathways by blocking nuclear factor of activated T cells [53]. Oral cyclosporine is also effective for the treatment of severe cases of elderly AD when administered at an optimal and sufficient dose (e.g., 3 mg/kg/day) [39, 80]. However, clinicians must pay attention to long-term use of cyclosporine in older patients with AD due to the potential increased risks of malignancy such as non-melanoma skin cancer or lymphoma [81, 82] and organ toxicity, especially in the cardiovascular system and kidney [43, 80, 83]. Therefore, the duration of use of oral cyclosporine for older patients with AD should be no longer than 12 weeks, although it could be restarted intermittently after withdrawal of 2 weeks or more [39]. In general, the risk of carcinogenesis increases with aging [84], and renal dysfunction is common in older individuals. Thus, older people are more likely to be concerned about these adverse effects of oral cyclosporine. Unfortunately, after stopping the use of oral cyclosporine, relapse of symptoms is frequently observed in elderly AD. Furthermore, the price of cyclosporine is much higher than that of oral corticosteroids. Therefore, oral cyclosporine may be less commonly used in the treatment of elderly AD.

3.2.3 Phototherapy

As described in Sect. 3.2, powerful anti-inflammatory treatments such as oral corticosteroids or cyclosporine in combination with basic treatments may be needed for the management of elderly AD; however, underlying conditions (e.g., diabetes, hypertension, heart diseases, renal dysfunction, and medical history of hepatitis or tuberculosis) in older patients may preclude the use of such treatments. In such cases, narrow-band ultraviolet B (UVB; wavelength 311 ± 2 nm) at a dosage of approximately 0.35–0.70 J/cm2 per irradiation could be useful for the treatment of elderly AD (Fig. 1) as an adjunctive therapy [85]. The immunomodulatory effects of narrow-band UVB phototherapy for AD are achieved via suppression of immune pathways of Th2, Th22, and Th1 cells and their cytokines in the lesional skin of AD [86]. Of note, narrow-band UVB phototherapy may not be effective for treating acute exacerbations of AD, and overdose of irradiation may induce eczema flare-ups [68, 85]. Slight irritation and mild diffuse pigmentation or solar lentigo may occur after irradiation as adverse effects of narrow-band UVB [85]. In principle, narrow-band UVB phototherapy should not be combined with oral cyclosporine or topical calcineurin inhibitors because the risk of skin cancer may increase with this combination treatment [53, 68]. Hospitalization may be required for phototherapy irradiation of more than three times a week as an initial treatment in older patients with AD. Patients must visit the hospital every week or every other week for continuous irradiation as an outpatient in a therapeutic period from weeks to months, and this may represent a burden of disease for older patients with AD [42, 85].

Fig. 1
figure 1

Clinical course in an older female patient with refractory atopic dermatitis after the combined use of basic treatments and additional therapies. a Skin manifestation at the exacerbation period (immediately before the start of phototherapy) at 61 years of age (EASI 29.4; laboratory data: total IgE 9410 IU/mL, TARC 5736 pg/mL, and peripheral eosinophil count 2070 μL). b After narrow-band ultraviolet B phototherapy (4 weeks after starting phototherapy) at 62 years of age (EASI 17.6; laboratory data: not tested). c After dupilumab therapy (1 year after starting subcutaneous injection therapy) at 66 years of age (EASI 3.5; laboratory data: total IgE 2890 IU/mL, TARC 377 pg/mL, and peripheral eosinophil count 421 μL). EASI Eczema Area and Severity Index, IgE immunoglobulin E, TARC thymus and activation-related chemokine

3.2.4 Biologics

At present, dupilumab is the only approved biologic for the treatment of AD. Dupilumab is a fully human monoclonal antibody against the α-subunit of IL-4 receptors that blocks signaling from both IL-4 and IL-13, which are key Th2 cytokines in the pathophysiology of AD [25, 27, 43, 53, 68]. Subcutaneous injection therapy of dupilumab (300 mg every 2 weeks after a loading dose of 600 mg) markedly improves skin lesions and itch in adult patients with moderate-to-severe AD with a rapid response and non-serious adverse effects [87,88,89,90]. Good efficacy for adult and older patients with AD (Fig. 1) has been reported, along with decreased expression of genes involved in Th2-associated cytokines/chemokines, epidermal hyperplasia, T cells, dendritic cells, and Th17/Th22 activity in the lesional skin after therapy [89, 90]. Dupilumab could be used as a substitute therapy for oral corticosteroids or cyclosporine in patients with inadequate response or adverse effects following application of those therapies [91]. Dupilumab is also useful for patients with complications of other Th2-immunopathway disorders such as bronchial asthma [92]. The effectiveness of dupilumab in the treatment of other pruritic skin disorders in older adults such as idiopathic chronic eczematous eruption of aging [32] may indicate the existence of common Th2-immunodominant etiological backgrounds in elderly AD and other pruritic skin disorders.

Major disadvantages of dupilumab treatment are conjunctivitis [93, 94] and inadequate efficacy for residual erythematous dermatitis on the face and neck [95,96,97]; however, the former can be successfully treated with fluorometholone 0.1% eye drops or tacrolimus 0.03% eye ointment [92, 93] and the latter may improve with combined antifungal therapy (e.g., topical ketoconazole or oral itraconazole) or topical tacrolimus with allergen avoidance (e.g., shampoo) under expecting a therapeutic effect on paradoxical worsening of hepersensitivity (probably Th1 hyper-response caused by the suppression of Th2 immunity) to Malassezia species or environmental contact allergens [95,96,97]. The burden of disease in dupilumab therapy for older patients with AD may be injection pain, expensive medical care, and regular visits every 2 weeks for the therapy. Home self-injections of the expensive and somewhat painful biologics might be difficult for older patients with AD who have potentially decreased self-care ability.

3.3 Other Treatments and New Drugs

In moderate-to-severe cases, hospitalization for basic treatments with or without additional therapies is useful in the management of elderly AD.

Oral administration of antimicrobial drugs is not effective for AD treatment without signs of infection; therefore, oral antibiotics are recommended for use only in cases with obvious clinical signs of infection [39, 43]. Antiviral therapy is also needed for patients with AD and herpes simplex infection at the time of viral activation with vesicular formation on the lips and pubic area [43, 53]. Interestingly, patients with elderly AD and herpes simplex infection might have a decreased tendency to develop a widespread severe form of the infection, i.e., eczema herpeticum; however, the cause of this is unknown.

There are several off-label therapies that might be used for older patients with AD as simultaneous treatment for complications (e.g., urticaria, bronchial asthma, allergic rhinitis, or rheumatic disorders), with an expected but uncertain therapeutic effect, e.g., omalizumab (anti-IgE), rituximab (anti-cluster-of-differentiation [CD] 20), and ustekinumab (anti-IL-12/IL-23) as biologics, methotrexate and azathioprine as immunosuppressants, and a sublingual agent of the HDM extract as allergen-specific immunotherapy [27, 43, 53, 68].

In addition, global approval of several new drugs is expected in the near future, including anti-pruritic drugs such as histamine H4 receptor-blocking antihistamines, small molecules such as phosphodiesterase (PDE) 4 inhibitors and Janus kinase inhibitors, and biologics such as anti-IL-31 receptor antibody. In the United States and Canada, topical crisaborole (a novel PDE4 inhibitor) is already approved and available as a new option for patients with mild-to-moderate AD [98]. These treatments are currently being evaluated for efficacy and safety in worldwide clinical trials in patients with moderate-to-severe AD [25,26,27, 43, 99, 100]. With the advent of these new drugs, the management of AD is anticipated to improve.

4 Conclusions

Although AD is not a life-threatening disease, it brings severe disruption to the quality of life of older patients with AD, who are in their last stage of life. In a retrospective analysis, it was found that the majority of older patients who died had continued to receive treatments for AD until just before death [8]. With current treatment options, complete remission (outgrowth, a condition without any need for treatment) is rarely achieved in elderly AD and, thus, most older patients reach the end of their life with AD.

In the near future, personalized care for patients with AD is anticipated, with targeted therapeutics utilizing differential strategies based on clinical phenotypes and endotypes of AD, biomarkers and molecular analyses, and co-morbidities and complications of patients [1, 11, 18, 24, 26, 27, 100]. Clinicians must prioritize treatments that reduce the burden of disease in older patients with AD.