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The Effect of Active Vitamin D Administration on Muscle Mass in Hemodialysis Patients

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Abstract

Background

Muscle wasting is common and insidious in end-stage renal disease (ESRD). Loss of muscle quantity and quality reduces quality of life and increases mortality in ESRD patients. Additionally, secondary hyperparathyroidism (SHPT) causes muscle atrophy. Meanwhile, vitamin D, which is used for SHPT treatment, plays an essential role in muscle growth.

Objectives

We prospectively investigated the effect of active vitamin D administration on muscle mass.

Methods

We measured muscle mass based on bioelectrical impedance analysis in 68 hemodialysis patients. Patients were divided into a control group (without active vitamin D administration) and a VitD group (with active vitamin D administration). We compared muscle mass at the beginning of treatment and 1 year later. We also investigated health-related quality of life (HR-QOL) using the Medical Outcome Study Short Form-36 (SF-36).

Results

The VitD group experienced a significant increase in the amount of change in total muscle mass and muscle mass percentage in men (p = 0.025) but not in women (p = 0.945). By multivariable logistic regression analysis, active vitamin D administration was independently associated with increased muscle mass percentage in men only. In the SF-36, the physical functioning (PF) scores were significantly decreased at the end of the study in the patients without active vitamin D treatment, especially in women.

Conclusion

Our results suggested that active vitamin D treatment was associated with increased muscle mass in men, and it might have a favorable effect on maintaining PF in HR-QOL in hemodialysis patients.

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Acknowledgments

This work was supported by research grant from the Japan Dialysis Outcome Research Group. All authors have no conflicts of interest.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Atsushi Mori, Tomoya Nishino, Yoko Obata, Masayuki Nakazawa, Misaki Hirose, Hiroshi Yamashita, Tadashi Uramatsu & Shigeru Kohno

  2. Medical Education Development Center, Nagasaki University Hospital, Nagasaki, Japan

    Yoko Obata

  3. Department of Infomatics, Nagasaki University Hospital, Nagasaki, Japan

    Misaki Hirose

  4. Division of Blood Purification, Nagasaki University Hospital, Nagasaki, Japan

    Hiroshi Yamashita

  5. Shinzato Medicare Center, Nagasaki, Japan

    Ken Shinzato

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  1. Atsushi Mori
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  2. Tomoya Nishino
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  9. Shigeru Kohno
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Correspondence to Tomoya Nishino.

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Mori, A., Nishino, T., Obata, Y. et al. The Effect of Active Vitamin D Administration on Muscle Mass in Hemodialysis Patients. Clin Drug Investig 33, 837–846 (2013). https://doi.org/10.1007/s40261-013-0132-7

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  • DOI: https://doi.org/10.1007/s40261-013-0132-7

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