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Association of quality of life assessed by the SF- 36 with low muscle strength and low lean mass combination in maintenance hemodialysis patients

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Abstract

Objective

The dialysis process increases the risk of sarcopenia, which is characterized by the loss of muscle mass and strength. With this, there may be a decrease in functional capacity and quality of life. This study aimed to evaluate the association between quality of life and sarcopenia in maintenance hemodialysis patients.

Methods

Cross-sectional study, which included adults with chronic kidney disease on hemodialysis for at least 1 month. Participants were characterized according to demographic, clinical, laboratory, and anthropometric data. Quality of life was assessed using the Short Form-36 (SF-36). Handgrip strength, Short Physical Performance Battery, sit-to-stand test, and gait speed were evaluated. Lean mass (LM) was estimated by a validated formula. The classification of the low muscle strength and low LM combination was based on the combination of reduced handgrip strength and LM index. Multiple linear regression models with SF-36 domains as the dependent variable and sarcopenia as the independent variable were used to verify whether low muscle strength and low LM in combination is associated with the SF-36 domains.

Results

134 patients were included in the study, with a mean age of 58.1 ± 14.7 years, 60.4% male. Forty-one individuals (30.6%) were classified with both low muscle strength and low LM. Both lean mass and lean mass index were significantly different between genders (p < 0.001). Mean age was significantly higher, and handgrip strength, lean mass, and lean mass index were significantly lower in patients with the low muscle strength and low LM combination, as expected. Regarding the quality of life, the physical functioning domain was significantly lower among patients classified with both low muscle strength and low LM. This domain was associated with the low muscle strength and low LM combination in the multiple analysis.

Conclusion

Only the physical functioning domain was associated with the low muscle strength and low LM combination in this sample of patients on hemodialysis. The other quality of life domains evaluated by the SF-36 were not associated with the low muscle strength and low LM combination.

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Data availability

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

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Acknowledgements

We thank the patients who participated in this study and the staff of the Dialysis Unit of the Clinics Hospital of the Botucatu Medical School and the Dialysis Unit of the Hospital Regional de Presidente Prudente.

Funding

JMS was funded by Programa de Educação Tutorial—Pró-Reitoria de Graduação / UFU. JMSR and KJA were funded by a master's degree scholarship, provided by Coordination of Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—CAPES), an organization of the Brazilian federal government under the Ministry of Education.

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Authors and Affiliations

  1. Nutrition, Medicine Faculty, Federal University of Uberlandia (UFU), Medicine Faculty, Uberlandia, Brazil

    Juliane Maia Silva & Barbara Perez Vogt

  2. University of Western Sao Paulo (Unoeste), Presidente Prudente, Brazil

    Letícia Salmazzo Alves

  3. Federal University of Uberlandia (UFU), Graduate Program in Health Sciences, Medicine Faculty, Uberlandia, Brazil

    João Marcos Soares Reis & Barbara Perez Vogt

  4. Department of Internal Medicine, Botucatu Medical School, UNESP Sao Paulo State University, Botucatu, Brazil

    Karina Jesus Antônio & Jacqueline Costa Teixeira Caramori

Authors
  1. Juliane Maia Silva
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  4. Karina Jesus Antônio
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Contributions

JMS: Formal Analysis, Visualization, Writing – original draft.

LSA: Data Collection, Writing – Review & Editing.

JMSR: Data Collection, Writing – Review & Editing.

KJA: Data Collection, Writing – Review & Editing.

JCTC: Methodology, Supervision, Writing – proofreading & editing.

BPV: Conceptualization, Formal Analysis, Methodology, Project Management, Resources, Supervision, Writing – proofreading & editing.

All authors read and approved the final manuscript.

Corresponding author

Correspondence to Barbara Perez Vogt.

Ethics declarations

Ethical approval

The studies involving human participants were reviewed and approved by the Research Ethics Committee of the Faculty of Medicine of Botucatu – São Paulo State University (CAAE 71393717.7.0000.5411) and the Research Ethics Committee of the University of Western Sao Paulo (CAAE 73640317.9.0000.5515). The participants provided their written informed consent to participate in the studies.

Competing interests

None.

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Silva, J.M., Alves, L.S., Reis, J.M.S. et al. Association of quality of life assessed by the SF- 36 with low muscle strength and low lean mass combination in maintenance hemodialysis patients. Nutrire 48, 41 (2023). https://doi.org/10.1186/s41110-023-00229-4

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