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Cost-Effectiveness of a School-Based Social and Emotional Learning Intervention: Evidence from a Cluster-Randomised Controlled Trial of the Promoting Alternative Thinking Strategies Curriculum

Abstract

Background

School-based social and emotional learning interventions can improve wellbeing and educational attainment in childhood. However, there is no evidence on their effects on health-related quality of life (HRQoL) or on their cost effectiveness.

Objective

Our objective was to evaluate the cost effectiveness of the Promoting Alternative Thinking Strategies (PATHS) curriculum.

Methods

A prospective economic evaluation was conducted alongside a cluster-randomised controlled trial of the PATHS curriculum implemented in the Greater Manchester area of England. In total, 23 schools (n = 2676 children) were randomised to receive PATHS, and 22 schools (n = 2542 children) were randomised to continue with usual practice. A UK health service perspective and a 2-year time horizon were used. HRQoL data were collected prospectively from all children in the trial via the Child Health Utility Nine-Dimension questionnaire. Micro-costing was undertaken to estimate the intervention costs. Missing data were imputed using multiple imputation.

Results

The mean incremental cost of the PATHS curriculum compared with usual practice was £32.01 per child, and mean incremental quality-adjusted life-years (QALYs) were positive (0.0019; 95% confidence interval [CI] 0.0009–0.0029). Assuming a willingness-to-pay threshold of £20,000 per QALY, the expected incremental net benefit of introducing the PATHS curriculum was £5.56 per child (95% CI − 14.68 to 25.81), and the probability of cost effectiveness was 84%. However, this probability fell to 0% when intervention costs included teacher’s salary costs.

Conclusion

The PATHS curriculum has the potential to be cost effective at standard UK willingness-to-pay thresholds. However, the sensitivity of the cost-effectiveness estimates to key assumptions means decision makers should seek further information before allocating scarce public resources.

Trial registration number

ISRCTN85087674.

FormalPara Key Points for Decision Makers
Table 1

Introduction

The development of age-appropriate social and emotional skills such as empathy and self-regulation during infancy, childhood and adolescence represent important milestones [1]. They are associated with a range of important later-life outcomes, including mental health and wellbeing, health and health behaviours, family and relationship stability and labour market success [2]. Improving these skills is key for driving social progress [3], and national guidelines encourage their promotion in children [4,5,6].

Social and emotional learning (SEL) interventions have grown significantly in popularity in recent years [7]. These aim to improve social and emotional skills via explicit instruction in the context of safe, caring, well-managed and participatory learning environments. Four recent meta-analyses provided robust evidence that SEL interventions can enhance such skills, attitudes towards self and others, mental health, and academic attainment of children and young people [8,9,10,11]. A fifth demonstrated that these effects are sustained over time [12].

One SEL intervention, the Promoting Alternative Thinking Strategies (PATHS) curriculum, was recommended to the UK government as part of an influential report on early interventions in child development [13]. Developed in the USA, the aim of PATHS is to promote self-control, emotional understanding, positive self-esteem, relationships and interpersonal problem-solving skills among children in pre-school and primary education settings through the provision of a taught curriculum [14]. Numerous randomised controlled trials (RCTs) have consistently established small-to-moderate effects on a range of outcomes, including children’s social and emotional skills, externalising problems (e.g. aggressive behaviour) and academic attainment [15,16,17,18,19,20,21,22,23,24,25]. However, many trials finding positive effects of PATHS have involved or been led by the developer. The small number of independent trials conducted in the USA [18], Switzerland [22] and England [20] have largely yielded null results.

Furthermore, there is currently no published cost-utility analyses (CUAs) of PATHS [26]. A single study conducted a micro-costing of a pre-school PATHS intervention but did not compare costs with outcomes because no statistically significant effects on social and emotional wellbeing were found [20]. The only cost-effectiveness analysis (CEA) of an SEL intervention examined the value for money of a different intervention, the Social Skills Improvement System (SSIS) and also measured programme benefits using social skills only [27]. In the UK, national guidelines have repeatedly called for more information on the value for money of SEL interventions [5, 6]. CUA is required for PATHS to garner funding from the UK national health service (NHS). CUA also provides advantages over CEA in this context because benefits are measured using HRQoL, which allows the measurement of effects on domains of health other than social and emotional wellbeing and provides a cost-effectiveness threshold that can be used to benchmark value for money against that of alternative interventions.

This study collected primary data on HRQoL and PATHS intervention costs to conduct a trial-based economic evaluation following the National Institute for Health and Care Excellence (NICE) reference case [28]. It is the first study to conduct a CUA of a universal SEL intervention, and it does so using data from one of the few RCTs run independently of intervention developers.

Methods

Trial Design

Full details of the trial design and participants are reported elsewhere [29]. In brief, a two-arm cluster RCT design was utilised, with schools used as the unit of randomisation. Schools were randomly allocated on a 1:1 basis to implement PATHS or continue with their usual practice. Data were collected at baseline (May–July 2012) and at 12- and 24-month follow-ups. Adaptive stratification was employed to ensure that the trial arms were balanced on the proportions of children eligible for free school meals and speaking English as an additional language (EAL). Randomisation was performed independently by the Manchester Academic Health Science Centre Clinical Trials Unit. The study received ethical approval from the University of Manchester Research Ethics Committee (Ref: 11470).

Participants

All mainstream, state-maintained institutions providing education for children aged 4–11 years in the ten local authorities in Greater Manchester were eligible for the study. School participation required consent from the head teacher. Participants within each school were children aged 7–9 years at baseline (year groups 3–5). Child participation required a lack of parental and child opt-out.

Sample Size

Initially, 58 schools were recruited, 45 of which met the eligibility criteria for randomisation. In total, 23 schools were randomised to receive PATHS; 140 parents (3%) exercised their right to opt their children out of the trial. A total of 5218 children participated in the study (n = 2676 in the intervention arm).

Characteristics of participating schools mirrored those of primary schools in England in respect of attendance, attainment and proportion of pupils speaking EAL but were significantly larger, with higher proportions of pupils eligible for free school meals and lower proportions identified as having special education needs. Characterisics of participating pupils (aged 7–9 at baseline) aligned closely with those of English primary school-aged children [30, 31], although the prevalence of children eligible for free school meals and speaking EAL was higher [32,33,34,35].

Intervention and Comparator

Intervention

Each participating class received curriculum packs containing lessons (and some supplementary send-home activities) built around four conceptual units (emotional understanding, self-control, social problem-solving, peer relations and self-esteem), plus associated material resources (e.g. posters, feelings dictionaries) [36]. Teachers also received a guidance manual developed by the research team that emphasized the programme theory and importance of effective implementation.

PATHS was implemented and delivered by class teachers as part of the general classroom timetable for year groups 3–5 in the first year of the trial (4–6 in the second year). All were qualified teachers and had an average of 8 years’ teaching experience; 81% were female. PATHS lessons lasted 30–40 min and were designed to be delivered twice weekly throughout the school year. Curriculum packs contained an average of 40 lessons.

In the first year of the trial, teachers of year groups 3–5 in the treatment arm received a full day of initial group training prior to the school year, with a half-day follow-up 4 months later. This training was led by certified trainers from Pennsylvania State University (PSU). They were aided by three PATHS coaches from the research team, who received training on supporting PATHS implementation during a visit to PSU. Where teachers could not attend the group training sessions, one-on-one training was carried out by a PATHS coach. Where teachers left part-way through a school year, training for replacement teachers was also carried out on a one-on-one basis by a PATHS coach.

In the second year of the trial, teachers of year group 6 and newly starting year group 4–5 teachers also received the above training. PATHS coaches conducted all second-year training and provided teachers with ongoing technical support and assistance, including modelling of and feedback on lessons.

Usual Practice

School-level surveys ascertaining the level of engagement with non-PATHS SEL-related activities were completed by the member of staff with lead responsibility for personal, social and health education in both PATHS and control schools before and during the intervention period. Findings from these surveys, presented elsewhere [29], revealed that, both pre and post-implementation, schools in both the PATHS and the control arms engaged in a range of other SEL-related activities. The volumes of these activities were relatively balanced across arms pre-PATHS implementation. Post-PATHS implementation, most control schools were implementing the universal elements of the Social and Emotional Aspects of Learning (SEAL) programme [37] (82% using the whole school resources, such as assemblies; 72% delivering SEAL lessons) and were delivering the National Healthy Schools Programme [38] (75%) and Circle Time [39] (60%). In total, 32% of control schools were using nurture groups [40], 28% were implementing the small group work component of SEAL, 25% were involved in the Targeted Mental Health in Schools initiative [41] and 26% were using restorative justice techniques [42]. All of these activities were conducted in classroom time and delivered by classroom teachers, and all aimed to improve children’s emotional wellbeing. Although PATHS was designed to be implemented in addition to these other activities, a comparison of pre and post-implementation surveys suggested that PATHS did lead to some displacement of other SEL-related activities, with reductions primarily seen for elements of the SEAL programme [29].

Perspective and Time Horizon

A 2-year time horizon (consistent with the length of the trial) was used. Analysis was conducted from a UK health service perspective, assuming that the NHS would fund incremental costs of PATHS compared with costs incurred in usual practice (e.g. additional training requirements) but that schools would continue to be responsible for costs involved in the delivery of the curriculum (e.g. teachers’ salary costs).

Outcome Measure

The Child Health Utility Nine-Dimension (CHU-9D) is a generic, multi-attribute, preference-based measure of HRQoL constructed specifically for use in children aged 7–11 years [43, 44]. It measures HRQoL based on nine attributes (worried, sad, pain, tired, annoyed, schoolwork/homework, sleep, daily routine and activities), each scored on five levels. Preference weights derived using the standard gamble method in a sample of UK adults were used to transform responses to the CHU-9D to utility values ranging from 0.33 to 1 (perfect health), with a value of 0 equivalent to death [45].

Participants self-completed the CHU-9D questionnaire in a classroom setting at baseline and at the 12-month and 24-month follow-ups. CHU-9D utility values at each time point were used to calculate quality-adjusted life-years (QALYs) using the area under the curve method, assuming utilities followed a linear path over time [46]. QALYs were discounted at a rate of 3.5%.

Intervention Costs

Cost analysis was based on only the costs of the PATHS intervention itself, as resource use data (e.g. use of educational psychologists) were not collected alongside the trial. Micro-costing was used to calculate the incremental costs of the intervention in the trial setting, compared with usual practice. Incremental costs comprised costs of materials, training for teachers and PATHS coaches and ongoing support. Specific cost components, assumptions and sources of unit costs are provided in Table 1, with further detail in Appendix 1 in the Electronic Supplementary Material (ESM).

Table 1 Assumptions and sources of unit costs for costing in the trial setting and roll-out scenario

Costs were assigned as recurrent or non-recurrent (full justifications are provided in Appendix 1 in ESM). As non-recurrent costs (classroom materials, PATHS coach training and initial full-day classroom teacher training) were likely to provide benefits beyond the trial period, costs were annuitized over their expected life at a discount rate of 3.5% [47]. The expected life of classroom materials and PATHS coach training was set equal to the expected life of the intervention (5 years) [20]. For initial-full day classroom teacher training, the expected life was set equal to the minimum of either the 5-year expected intervention life or the expected length of service for a teacher. The latter was estimated as the reciprocal of the annual rate of teacher attrition across both years of the trial, assuming a constant attrition rate.

Costs were reported in £ and inflated to year 2018/19 values. Costs incurred beyond the first year of the trial were discounted at a rate of 3.5%.

The total incremental cost of the intervention was derived by summing across all cost elements. Per-child incremental costs were calculated by dividing total cost by the number of children receiving the intervention (n = 2745), comprising 2676 study participants and 69 opt-outs from the PATHS arm.

Missing Data

The proportion of children with any missing data on CHU-9D utility values over all time points was 51%. We followed recommendations outlined in a recent guide to handling missing data in within-trial CEAs [48].

Descriptive analysis found large differentials in missing data across trial arms, with a smaller proportion of individuals in the control arm providing CHU-9D utility values at all time points (Appendix 2 in the ESM). This reflected increased missingness at the 12- and 24-month follow-ups, primarily because five control schools failed to provide follow-up data. Logistic regression models also identified a range of baseline covariates measured at both the child level (ethnicity, free school meals eligibility, special education needs) and the school level (school size) as predictors of CHU-9D missingness. The existence of any predictors of missingness provided evidence against data being missing completely at random. Logistic regressions also confirmed that the probability of CHU-9D missingness in any given time period significantly decreased with higher CHU-9D utility values in all other waves, providing evidence against covariate-dependent missingness. Data were therefore treated as missing at random, assuming the probability of missingness was independent of unobserved factors, i.e. factors other than baseline covariates and CHU-9D utility values in other waves.

Consistent with the missing at random assumption, multiple imputation (MI) methods using chained equations were employed to handle missing CHU-9D data. Given low levels of domain-specific missingness for the CHU-9D, utility scores were imputed. In total, 50 imputations were chosen—approximately equal to the percentage of cases with missing data [49].

Imputation was carried out separately by trial arm, as the posterior conditional distribution of the missing data given the observed data may differ across treatment arms [50]. Predictors included in the imputation model included the CHU-9D utility values at all other time points and a range of child-level (e.g. sex, year group) and school-level (e.g. school size) covariates, consistent with the main trial [29]. Single-level MI was conducted, assuming all between-school variation in missingness was accounted for by school-level covariates.

To account for the skewness and multi-modality in the distribution of CHU-9D utility values, predictive mean matching was used to impute CHU-9D utility values [49]. Incremental QALYs were calculated as the mean of incremental QALY estimates generated in each imputed dataset, following Rubin’s rule. The validity of the imputation procedure was confirmed by establishing similarity in the distribution of non-missing and imputed QALYs [51].

Data Analysis

Incremental costs and QALYs were modelled separately. The incremental cost of PATHS was calculated as the simple difference between costs in the treatment and control arms and was equal to the average child-level incremental intervention costs. To estimate incremental QALYs, child-level random intercept models were used to account for clustering of outcomes at school level. Explanatory variables comprised intervention status (PATHS vs. control), baseline CHU-9D utility values [46] and the child-level and school-level covariates used in the imputation model.

Presentation of Results

The main trial found PATHS led to very small improvements in children’s psychological wellbeing and no improvements in social skills and mental health problems relating to internalising and externalising behaviour [29]. Negative incremental QALY estimates were therefore possible. Consequently, incremental net benefits (INBs) were chosen over incremental cost-effectiveness ratios (ICERs) to present results [52] and were calculated as follows:

$${\text{INB}}\left( \lambda \right) = \lambda \left( {{\text{QALY}}_{p} - {\text{QALY}}_{u} } \right) - \left( {{\text{cost}}_{p} - {\text{cost}}_{u} } \right)$$

\(p\) and \(u\) refer to intervention and control arms, respectively, and \(\lambda\) denotes the cost-effectiveness threshold, representing willingness to pay (WTP) for an additional QALY. PATHS was deemed cost effective at a given threshold if the INB was positive. INBs were estimated for thresholds ranging from £0 to 150,000, increasing in £1000 increments. In the UK, NICE sets this threshold at £20,000–30,000 [28].

Identifying Sample Uncertainty

Uncertainty was examined via non-parametric bootstrapping techniques using 10,000 iterations. This was combined with the MI methods as follows. First, for each bootstrap replication, a sample size of 5218 was randomly drawn with replacement from each of the 50 imputed datasets. Incremental QALYs and costs were re-estimated within each sample and Rubin’s rules used to combine incremental statistics across samples in each imputed dataset to form average statistics for the bootstrap replication. INBs were then calculated for each value of the threshold within each bootstrap replication, and standard bootstrap methods were used to construct confidence intervals [53]. These estimates were then used to construct cost-effectiveness acceptability curves (CEACs).

One-Way Sensitivity Analyses

We undertook five one-way sensitivitiy analyses. First, we examined the robustness of results to using alternative preference weights for constructing CHU-9D utility values derived using a best–worst scaling discrete-choice experiment in an Australian adolescent sample, which assign greater weights to the CHU-9D mental health domains [54]. Second, we examined the effect of performing a complete case analysis where all observations with missing data were removed. Third, we explored the impact of changing the expected life of the intervention from 5 to 10 years when annuitizing non-recurrent costs.

Fourth, we considered the effects of including costs relating to classroom teachers’ time spent training, preparing for and delivering the intervention as previous studies have treated these costs as incremental [20, 55]. These costs were not considered as incremental in the base-case analysis as the fixed-length school day means PATHS necessarily displaced other components of the school curriculum that required equal time resources and therefore consumed identical time resources as in usual practice [56]. Teacher’s salary costs are currently paid by the UK Department for Education. These costs would therefore only be considered incremental under a UK health sector perspective if the NHS were to agree to fund the costs of the proportion of the school day required for PATHS implementation. We examined the effects of assuming 40 min [56] or 45 min [20] of preparation time per teacher per week.

Finally, we costed the intervention in a hypothetical scenario similar to that in the event of nationwide roll-out, given that these costs would likely differ from those incurred in the trial. The assumptions in the roll-out scenario are presented in Table 1 and in Appendix 3 in the ESM. Costs were based on those charged by Birmingham City Council, as they were the only council providing a traded PATHS service with English schools during the implementation period [56]. This provided a total bundled cost of PATHS for a single-form entry school with seven year groups (reception to year 6). This cost included (1) a curriculum pack and supplementary materials for each class, (2) initial training for seven teachers, (3) training of a PATHS coach/co-ordinator (usually a head teacher) and (4) 2 days of PATHS coaching support (assumed to occur in the first year and be non-recurrent). Unbundled costs for curriculum packs and supplementary material and full-day and half-day teacher training for seven teachers were also provided. Total costs were divided by seven to get a total cost per class and multiplied by the number of classes in the PATHS arm of the trial to get a cost equivalent to the size of the PATHS school sample. This cost was then divided by the number of children receiving the PATHS intervention to get an equivalent cost per pupil.

Results

School and Child Characteristics

Table 2 summarises the characteristics of all pupils in the 45 schools (PATHS: n = 23; control: n = 22) and the 5218 pupils (PATHS: n = 2676; control: n = 2542) in the trial. Randomisation generally achieved good balance across trial arms on school characteristics and trial participant characteristics, although PATHS schools had more pupils and a higher percentage of pupils with EAL than did control schools, and children in the PATHS arm were more likely to be eligible for free school meals and to be from a minority ethnic group.

Table 2 Sample school and pupil characteristics by trial arm

Incremental Intervention Costs

Micro-costing estimates for the base-case scenario are summarised in Table 3. Incremental non-recurrent costs associated with the PATHS materials and training for PATHS coaches and original teachers totalled £39,323 for the PATHS schools. Incremental recurrent costs totalled £48,550, driven primarily by the costs of ongoing support from PATHS coaches and follow-up teacher training. Overall, the total incremental cost of the intervention was £87,873, corresponding to an incremental cost per child of £32.01 for the 2745 receiving the intervention.

Table 3 Incremental costs of the Promoting Alternative Thinking Strategies (PATHS) intervention

Incremental Quality-Adjusted Life-Years

Average CHU-9D utility scores at baseline and each follow-up, and QALYs gained over the 2-year trial period, were higher for the PATHS arm than the usual practice arm after accounting for missing data (Table 4). Adjusting for baseline CHU-9D utility scores and child- and school-level covariates in a random intercept model, adjusted mean incremental QALYs for PATHS were 0.0019 (95% confidence interval [CI] 0.0009–0.0029).

Table 4 Health-related quality of life, quality-adjusted life-years, costs and incremental net benefits for PATHS arm and usual practice from the imputed sample

Cost-Effectiveness

Cost-effectiveness evidence for PATHS in the base-case analysis is summarised in Table 4 and Fig. 1. Assuming the minimum threshold used by NICE of £20,000 per QALY, the expected INB of introducing PATHS was £5.56 per child (95% CI − 14.68 to 25.81), and the probability of PATHS resulting in a positive INB, and therefore being cost effective, was approximately 84% (Fig. 1). The probability of cost effectiveness exceeds 50% for WTP thresholds beyond £15,100.

Fig. 1
figure 1

Cost-effectiveness acceptability curves of the PATHS curriculum versus usual practice: base-case and sensitivity analysis. CHU-9D Child Health Utility—Nine Dimensions, PATHS promoting alternative thinking strategies, Prep preparation

Sensitivity Analyses

Figure 1 presents CEACs detailing the sensitivity analyses. Using the best–worst scaling algorithm to derive CHU-9D utility values increased mean incremental QALYs to 0.0028 (95% CI 0.0015–0.0040), increasing the probability of cost effectiveness at all threshold values and increasing the probability of PATHS producing a positive INB at a WTP of £20,000 per QALY to 99.4% (Fig. 1).

Removing observations with at least partial missing data in a complete case analysis resulted in a small negative estimate of mean incremental QALYs (− 0.000028; 95% CI − 0.0101 to 0.0101). The resulting probability of cost effectiveness at the £20,000 per QALY threshold was 40%.

Assuming a 10-year rather than 5-year expected intervention life led to a small reduction in incremental costs of £3.50 per child (Table 5), increasing the probability of PATHS being cost effective at a WTP of £20,000 per QALY to 91.0%.

Table 5 Incremental costs of the Promoting Alternative Thinking Strategies (PATHS) intervention in sensitivity analyses: (1) 10-year intervention life, (2) inclusion of teacher’s salary costs

Inclusion of teacher salary costs had a substantial impact on both incremental costs and INB statistics irrespective of the assumption made regarding the required lesson preparation time for PATHS lessons. Incremental costs increased to over £200 per child (Table 5) and a 0% probability of PATHS being cost effective at conventional UK thresholds of WTP for a QALY.

In the roll-out scenario, the per-child incremental cost of the intervention was estimated to reduce from the base-case cost of £32.01 to £19.07. At this cost, the probability of PATHS being cost effective was 98.7% for a WTP threshold of £20,000 per QALY and exceeded 50% for WTP thresholds beyond £9000.

Discussion

This study is the first prospective economic evaluation of an SEL intervention examining impacts on HRQoL. It was conducted via a cluster-randomised controlled trial in the UK and independently of intervention developers. It also represents one of the first economic evaluations in which HRQoL was measured using the CHU-9D and grows the limited number of economic evaluations of paediatric interventions using preference-based instruments of HRQoL designed specifically for children [57].

The base-case analysis indicated that PATHS led to a small increase in QALYs and, as a result of small incremental intervention costs, that PATHS is likely to be cost effective at conventional thresholds of WTP of £20,000 and £30,000 per QALY used in the UK [28]. However, the probability of cost effectiveness would decrease to approximately 25% assuming a proposed lower threshold of £12,936 per QALY [58].

The demonstrated small, positive effects of PATHS on HRQoL are consistent with the positive effects on other child outcomes reported in US-based developer-led trials [15,16,17, 19, 21, 23, 24]. However, they are inconsistent with the largely null findings from international independent RCTs examining impacts on social and emotional skills and mental health [18, 22, 59]. The CHU-9D may be capturing wider health benefits of PATHS and/or the CHU-9D preference weights may be placing higher weights on the outcomes improved by PATHS.

Our sensitivity analyses offer key information for policy makers deciding whether to recommend PATHS for nationwide roll-out. Whether PATHS is cost effective depends most on whether costs of teacher preparation and delivery time fall on the decision maker. By providing point estimates for costs, QALYs and INBs, alongside CEACs, we provide the opportunity for decision makers to select results aligned with their own WTP and the assumptions most applicable to their setting.

This research also highlighted the considerable difficulty in costing an intervention in a school setting. Even ignoring the idiosyncrasies of this particular trial, teacher turnover is commonplace in all schools but have not been considered in previous studies of this type [20, 55]. In these studies, non-recurrent training costs are annuitized over the expected life of the intervention, and an implicit assumption is made that the teacher turnover rate is zero during this period. Furthermore, the cost of training replacement teachers has not been considered. Given this, a failure to recognise teacher turnover has likely led to an underestimation of the costs of PATHS interventions.

The study has a number of limitations. First, no data on the use of either school-based health services, such as education psychologists and art/drama therapy, or external health services, such as visits to hospitals, general practitioners and psychiatrists, were collected alongside the trial. It is unclear how the inclusion of these costs would have impacted the incremental costs of the intervention. Improvements in QALYs could have led to a reduction in the need to access curative services. However, it is possible that PATHS led to an identification of unmet need, particularly through increased awareness of socio-emotional disorders, leading to an increase in the use of these services. Positive incremental QALYs could partially reflect this increase in use.

Second, a UK health sector perspective was chosen, consistent with the perspective typically used in CEAs. A cost-consequence analysis using a public sector perspective could have captured benefits falling in sectors other than health [60]. However, the main trial found no statistically significant effects on educational attainment or the rate of exclusions [29], suggesting that the potential for wider societal benefits may be limited. In addition, given the absence of data on resource use, incremental costs from a public sector perspective would be identical to those from a healthcare sector perspective in this study. Furthermore, cost-consequence analysis does not enable easy comparisons of interventions with disparate outcomes, whereas CUA provides an accepted benchmark with which to compare value for money. This evaluation was also constrained by its time horizon, which was set equal to the follow-up period of the main trial. Future research could use parameters estimated in this study to conduct a model-based evaluation of PATHS’ longer-term cost effectiveness.

Finally, there are several risks to the study’s external validity, which may have led to the effects of PATHS being underestimated. First, the annual teacher turnover rate in the trial (36%) was much higher than the national average (11%). If teacher continuity is positively correlated with implementation quality, then this may have resulted in reduced effectivenes compared with a roll-out scenario. Furthermore, as trial participants were not blinded to treatment, treatment spillovers and compensatory rivalry [61] may have led to a further underestimation of mean incremental QALYs and the INB. However, this issue is near impossible to avoid in school-based trials such as this [62]. Lastly, teacher training and ongoing support during the trial was conducted by expert staff from PSU and by members of the research team. If the quality of teacher training by school staff differs from that by PSU staff in a roll-out scenario, then the effectiveness and cost effectiveness of the intervention would be affected.

Conclusion

The findings of this economic analysis based on data collected in a large, independent, cluster-randomised controlled trial suggest that PATHS has the potential to be cost effective. However, there is considerable uncertainty around this conclusion; results are sensitive to the inclusion of costs associated with teachers’ time spent in training and delivery. Information presented in this study can support decision makers allocating scarce health resources and provide cost and benefit estimates that can be incorporated into model-based evaluations to assess the long-term cost effectiveness of PATHS.

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Acknowledgements

The authors are grateful to experts Professor Katherine Payne, Professor Rachel Elliot, Professor Linda Davies, Mr. Alexander Thompson and Dr. Sean Gavan at The University of Manchester for providing their thoughts and feedback on our analytical approach.

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Funding

The research presented in this manuscript was funded by the National Institute for Health Research (grant ref: 10/3006/01). The views expressed in this article are those of the authors and not of the funding body.

Conflicts of interest

Alex J Turner, Matt Sutton, Mark Harrison, Alexandra Hennessey and Neil Humphrey have no conflicts of interest that are directly relevant to the content of this article.

Author Contributions

Neil Humphrey conceived the study and designed the trial. Alexandra Hennessey was involved in the implementation of the trial and collection of data. Alex J Turner designed the economic methodology alongside Matt Sutton and Mark Harrison. Alex J Turner undertook the analysis and wrote the manuscript. All authors assisted with the interpretation of results and critically reviewed the manuscript.

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Turner, A.J., Sutton, M., Harrison, M. et al. Cost-Effectiveness of a School-Based Social and Emotional Learning Intervention: Evidence from a Cluster-Randomised Controlled Trial of the Promoting Alternative Thinking Strategies Curriculum. Appl Health Econ Health Policy 18, 271–285 (2020). https://doi.org/10.1007/s40258-019-00498-z

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