Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study
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- Vossen, A.R.J.V., Schoenmakers, A., van Straalen, K.R. et al. Am J Clin Dermatol (2017). doi:10.1007/s40257-017-0280-2
Pruritus is still a forgotten aspect of hidradenitis suppurativa (HS) and, to date, has never been adequately studied.
The aim of this study was to determine the prevalence, and explore the characteristics, of pruritus in a well-defined cohort of HS patients.
An academic hospital-based cross-sectional study in The Netherlands.
A numerical rating scale (NRS, 0–10) was used to determine the prevalence of HS-related itch (NRS score ≥3). Candidate predictors for pruritus were subsequently determined using logistic regression models, and the impact of pruritus was assessed using a modified five-dimensional (5-D) itch scale. Associated serological and histological markers of pruritus were (semi-)quantitatively investigated in a subpopulation.
The prevalence rate of pruritus in 211 HS patients was 57.3%, with a mean NRS score of 6.1 ± 2.0. Patients with a pruritus NRS score ≥3 had more HS-affected body sites than patients with a score <3 (p < 0.001). The occurrence of a pruritus NRS score ≥3 was associated with Hurley III disease (odds ratio [OR] 7.73; p = 0.003) and pain (OR 1.34; p < 0.001). Pruritus affected sleep and activities of daily living (ADL) in the majority of cases, with an associated modified 5-D itch score of 13.7 ± 3.6 (on a scale from 5 to 25) in 52 HS patients. Histological examination showed eosinophilic granulocytes were present in 25% (2/8) of the perilesional skin and 63% (10/16) of the lesional skin, while a perineural infiltrate was found in 25% (2/8) and 69% (11/16) of the perilesional and lesional skin, respectively.
Pruritus is a frequent but underreported symptom in patients with HS. Its moderate to severe intensity and significant impact on daily activities have great potential to impair patients’ quality of life.
Pruritus or itch is a frequent and bothersome symptom in hidradenitis suppurativa (HS).
The presence of eosinophilic granulocytes and a perineural infiltrate in lesional skin might explain the reason for pruritus in HS.
The assessment of itch in both daily practice and clinical research settings may form a helpful additional patient-reported outcome measure to evaluate the disease activity/severity of HS.
Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, recurrent, inflammatory skin disease that mostly develops after puberty and predominantly occurs in women, with a female-to-male ratio of 3:1 [1, 2]. The estimated prevalence rate in Europe is approximately 1% . Risk factors for developing HS are smoking and overweight or obesity . The disease is characterized by deep-seated, inflamed nodules and abscesses, often followed by sinus tract formation, and is most commonly located in the flexural body sites carrying terminal hairs .
Key symptoms of HS include acute and chronic pain, discomfort, and a purulent, foul-smelling discharge, which, overall, contribute to a poor quality of life [5, 6]. Previous clinical studies have mainly focused on these well-known symptoms [1, 4, 5], while less is known about the itch sensation, also known as pruritus. In 2011, a small qualitative study in which 12 HS patients were interviewed for the first time revealed that not only drainage, pain, and scarring but also itching have a significant psychosocial impact in HS patients .
To date, one cross-sectional study demonstrated a positive association between disutility and itch in a cohort of 294 HS patients, using the EuroQoL-5D (EQ-5D) and a visual analog scale (VAS), respectively . However, the prevalence and accompanying (psychosocial) factors of pruritus in HS have not been adequately investigated to date. The aim of this study was to determine the prevalence, and explore the characteristics, of pruritus in a cohort of HS patients. In addition, serological and histological markers of pruritus were evaluated in a subpopulation.
2 Materials and Methods
2.1 Study Design and Population
This cross-sectional study consisted of consecutive male and female patients with a physician-verified diagnosis of HS who visited the Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands. Each patient filled out a questionnaire relating to the intensity of pruritus and the pain caused by their HS. Patients with a limited understanding of the Dutch language, as well as patients with a concomitant skin disease that might cause pruritus (e.g. psoriasis, atopic dermatitis, chronic urticaria) were excluded.
2.2 Epidemiological and Clinical Parameters
Patients separately assessed the highest intensity of their pruritus and pain over the past 7 days on an 11-point numerical rating scale (NRS) ranging from 0 (no itch/pain) to 10 (unbearable/extreme itch/pain) . All patients with an NRS score ≥3 were included in the prevalence analysis. It has previously been demonstrated that the minimal clinically important difference (MCID) for clinical improvement in itch ranks as a decrease of 2.7 points rated on the NRS in the last 3 days .
Clinical parameters were collected during routine care and were derived from medical charts. HS severity was assessed using the Hurley classification of the worst affected body area , and the extent of disease activity was evaluated by the number of anatomical skin regions with inflammation. The presence of three or more papules/pustules, one or more inflammatory nodules, one or more draining sinuses, or one or more abscesses per region (left and right separate) was considered as inflammatory active HS disease. Additionally, the NRS relating to pain was used as the patient-reported outcome measure (PROM) of disease activity.
2.3 The Impact of Pruritus
Randomly selected patients with a pruritus NRS score ≥3 were asked to fill in a five-dimensional (5-D) itch scale, which is used to evaluate the impact of pruritus on daily activities and includes five domains—duration, degree, direction, disability, and distribution .The questionnaire was adapted through (1) translation into Dutch, and (2) explicitly mentioning the axillary and genital regions, with removal (i.e. points of contact with clothing) and merging (i.e. tops of feet and soles; palms and tops of hands; thighs and lower legs; forearms and upper arms) of non-relevant sections in the distribution domain. The latter was carried out to obtain better insight into the HS predilection areas, and resulted in 12, instead of 16, answer options (electronic supplementary material 1). The outcomes of domains 1–4 are measured on a 5-point Likert scale . The scoring system for the distribution domain was not adapted as it was not expected that HS patients without concomitant skin disease that might cause pruritus would have more than 12 skin regions with symptoms of itch. The overall 5-D score was calculated by adding up the individual scores of the five domains, resulting in scores ranging from 5 (no impact) to 25 (most severe impact on daily life) .
2.4 Serological Analysis
A random subset of HS patients aged ≥18 years with a pruritus NRS score ≥3 was asked for a one-time collection of a blood sample in order to screen for other possible causes of pruritus [13, 14].Tryptase, hemoglobin, bilirubin, creatinine, urea, thyroid-stimulating hormone (TSH), and glycated hemoglobin (HbA1c) were assessed in serum.
2.5 Histological Analysis
Histopathological analysis was performed on 24 random HS skin samples (including eight perilesional skin samples, and six early and ten chronic lesions) in order to evaluate potential skin-related mediators of pruritus. Large specimens of chronic inflamed skin were obtained from the excised skin of patients who had radical excision of their HS under general anesthesia as this was considered waste material. In our clinic, HS lesions are excised with a healthy-appearing skin margin of 2 cm; this normal-appearing skin is denoted as perilesional skin. All early (i.e. newly emerging) HS lesions, as judged by both the HS patient and the dermatologist, were biopsied within 4 days after onset.
Three independent observers (ARJVV, KRvS, and EPP), blinded to the disease stage, assessed all skin samples, stained by hematoxylin and eosin (H&E), on the density of the infiltrate, followed by evaluation of eosinophilic granulocytes and perineural involvement within the infiltrate. The outcomes were scored in a semiquantitative manner using a global assessment on an ordinal scale from 0 to 3 (0 = none, 1 = mild, 2 = moderate, 3 = severe) . Disagreements between the three observers were resolved through discussion until consensus was reached. The average overall score per category was calculated from the consensus score of the observers.
2.6 Statistical Analysis
Total [n = 211]
Pruritus NRS score ≥3 [n = 121]
Pruritus NRS score <3 [n = 90]
28.5 ± 5.9
28.7 ± 5.8a
28.3 ± 6.0b
Positive family historye
Use of systemic medication
Skin type (Fitzpatrick)f
Duration of HS, years
Currently inflamed areash
1.5 ± 1.3
1.7 ± 1.4
0.9 ± 1.1
Pain on NRS
6.3 ± 3.0
6.9 ± 2.5
5.0 ± 3.5
2.7 Ethical Statement
The Medical Ethical Committee of the Erasmus University Medical Center, Rotterdam, The Netherlands, reviewed and approved the study protocol (reference MEC-2016-092). Written informed consent for the serological and histological analysis was obtained from all subjects in accordance with the Declaration of Helsinki principles.
3.1 Epidemiology of Pruritus
A total of 231 HS patients were screened, of whom 20 were excluded (13 had a concomitant dermatological comorbidity causing itch, 5 had a limited understanding of the Dutch language, and 2 patients declined to take part in the study). The 211 patients included in the study (64% female) had a median age of 38 years (range 15–71) (Table 1). The prevalence rate (NRS score ≥3) of pruritus was 57.3% (121/211), with a mean NRS score of 6.1 ± 2.0. For comparison, applying a cut-off value of an NRS score ≥1 resulted in a rate of 67.3% (mean NRS score of 5.4 ± 2.5). The mean intensity of itch in all 211 patients was rated at an NRS score of 3.7 ± 3.3. The occurrence of pain (NRS score ≥3) was more frequently reported, resulting in a prevalence rate of 83.4% and associated mean NRS score of 7.4 ± 1.8.
3.2 Patient Characteristics
Associations between patient characteristics and the occurrence of itch in 211 HS patients
OR (95% CI)
OR (95% CI)
Duration of HS (years)
Currently inflamed areas
Pain on NRS
3.3 The Impact of Pruritus
3.4 Serological Analysis
Serum pruritus markers of 24 hidradenitis suppurativa patients with itch
Serum pruritus marker
6.0 ± 2.6
69.4 ± 16.8
38.9 ± 12.7
Men (n = 5)
8.4 ± 1.2
Women (n = 19)
8.4 ± 0.6
5.4 ± 3.5
1.6 ± 1.0
4.0 ± 1.5
3.5 Histological Analysis
For the first time, this explorative study evaluated the prevalence and clinical characteristics of pruritus in a well-defined cohort of HS patients. We demonstrated a high prevalence rate of 57% (121/211 with an NRS score ≥3), with a mean NRS score of 6.1 ± 2.0. This prevalence rate is substantially higher than the prevalence of itch in a healthy French population (29%) and a Norwegian national sample with several ethnicities (7%) [16, 17]. A recently conducted study involving a general dermatological population of a German clinical practice reported a 36% prevalence rate of itch . Compared with other inflammatory skin conditions, the 57% prevalence rate of pruritus in HS is similar to the rate in patients with psoriasis (49–90%) [18, 19], and lower than patients with burn injuries (67–93%) [20, 21] or chronic idiopathic urticaria (79%) .
The overall mean intensity of itch in this study (NRS score 3.7 ± 3.3) was similar to the pruritus VAS score of 3.7 ± 3.2 in a cohort of 294 HS patients . In addition, the mean modified 5-D itch score of 13.7 ± 3.6 in 52 HS patients is comparable with the 5-D score in 51 patients with an inflammatory skin condition such as burn wounds (13.5 ± 3.2) . Systemic diseases such as HIV/AIDS (n = 28; 16.8 ± 5.3), chronic liver disease (n = 63; 16.9 ± 4.7), and chronic kidney disease (n = 36; 18.2 ± 4.1) have shown higher 5-D itch scores ; however, the majority (81%) of HS patients ranked the severity of pruritus as moderate to severe on a 5-point Likert scale. Moreover, sleep and ADL were negatively impacted by pruritus in more than half of the patients.
Pruritus is a multidimensional phenomenon and is thought to signal danger from various environmental factors or physiological abnormalities. Therefore, it frequently accompanies various inflammatory skin conditions, including atopic dermatitis, psoriasis, chronic urticaria, and burn wound healing .To date, the etiology of pruritus in skin diseases is only partially understood. A possible explanation for itching in HS patients is the presence of tryptase-positive mast cells, which were found to be increased in all stages of the disease, including perilesional skin . Increased serum levels of immunoglobulin (Ig)E have recently been reported in patients with HS. The latter, in combination with a dense infiltration of mast cells in HS, could trigger degranulation of these cells, releasing histamine and other mediators, such as proteases, causing pruritus . In addition, we found an influx of eosinophilic granulocytes and the presence of a perineural infiltrate (when nerve fibers were present) in the majority of prototypic HS lesions. An important phenomenon supporting the hypothesis of neurogenic inflammation is the finding of an abnormal innervation of the skin in psoriasis . As demonstrated in cutaneous T-cell lymphoma, interleukin (IL)-31 may play a role by exerting indirect effects on sensory nerves through keratinocytes to transmit itch signals . However, itch in HS patients could also result from a small fiber neuropathy due to scar formation in the course of HS. Recurrent and chronic inflammation will destroy dermal nerves and subsequently enhance nerve regeneration and neovascularization when inflammation has subsided. This type of neuropathic itch coincides with pain and may be caused by a disproportionate number of regenerating, unmyelinated C nerve fibers within HS lesions .
The major strength of this explorative cross-sectional study is the recruitment of a relatively large number of physician-verified HS patients. As the occurrence of itch at a specific point in time is susceptible to confounders such as mental distress, use of systemic medication, and comorbidities , a comparator group and quality-of-life measurements, e.g. Dermatology Quality of Life Index (DLQI) or SKINDEX-29, are indicated for future research. Another strength is screening for common systemic causes of chronic recurrent itch that could interfere with the occurrence of HS-related itch. In addition, histopathological evaluation of two important skin-related mediators of pruritus have been performed, although the evaluation lacks information relating to the associated presence of pruritus. For future analysis, it would be interesting to evaluate specific itch-related biomarkers in the serum or skin lesions, such as eosinophilic granulocytes, thymus and activation-regulated chemokine (TARC), IL-2, IL-31, and substance P.
A limitation of this study could be the use of a non-validated, HS-modified 5-D itch scale. From a clinical point of view, the alteration of the distribution section was not expected to influence scoring as HS patients rarely have notable itch in distal, unaffected body sites such as the hands and feet. Moreover, the body areas mentioned in the distribution domain of the adapted scale are more specific to HS-related itch (electronic supplementary material 1). The modified 5-D itch scale, which could be validated for this application in future research, could therefore be a specialized and very useful tool for analysing pruritus in HS patients.
Pruritus is a frequent but underreported aspect of HS. Its moderate to severe intensity and significant impact on sleep and ADL have great potential to impair patients’ quality of life. Therefore, assessment of pruritus in both daily practice and clinical research settings, e.g. by using an NRS or VAS, together with the DLQI and EQ-5D, may form a helpful additional PROM to evaluate disease severity/activity and treatment outcome.
The authors thank Loes Hollestein, Epidemiologist, Department of Dermatology, Erasmus University Medical Center, for her assistance in the statistical analysis.
Compliance with Ethical Standards
No sources of funding were used to assist in the preparation of this article.
Conflicts of interest
Allard R.J.V. Vossen, Annelien Schoenmakers, Kelsey R. van Straalen, Errol P. Prens, Hessel H. van der Zee have no conflicts of interest to declare.
Ethical approval was provided by the Institutional Review Board of the Erasmus University Medical Center.
Statistical methods and tests were approved by Loes Hollestein (PhD), Epidemiologist, Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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