Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP, Margolis DJ, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134:1527–34.
CAS
PubMed
Article
Google Scholar
Holzmann R, Shakery K. Postadolescent acne in females. Skin Pharmacol Physiol. 2014;27(Suppl 1):3–8.
PubMed
Article
Google Scholar
Kim GK, Michaels BD. Post-adolescent acne in women: more common and more clinical considerations. Drugs Dermatol. 2012;11:708–13.
Google Scholar
Perkins AC, Maglione J, Hillebrand GG, Miyamoto K, Kimball AB. Acne vulgaris in women: prevalence across the life span. J Women’s Health (Larchmt). 2012;21:223–30.
Article
Google Scholar
Tan JK, Li Y, Fung K, Gupta AK, Thomas DR, Sapra S, et al. Divergence of demographic factors associated with clinical severity compared with quality of life impact in acne. J Cutan Med Surg. 2008;12:235–42.
PubMed
Article
Google Scholar
Dréno B, Layton A, Zouboulis CC, Lopez-Estebaranz JL, Zalewska-Janowska A, Bagatin E. Adult female acne: a new paradigm. J Eur Acad Dermatol Venereol. 2013;27:1063–70.
PubMed
Article
Google Scholar
Di Landro A, Cazzaniga S, Cusano F, Bonci A, Carla C, Musumeci ML, et al. Adult female acne and associated risk factors: results of a multicenter case-control study in Italy. J Am Acad Dermatol. 2016;75(6):1134–1141.e1.
Callender VD, Alexis AF, Daniels SR, Kawata AK, Burk CT, Wilcox TK, et al. Racial differences in clinical characteristics, perceptions and behaviors, and psychosocial impact of adult female acne. J Clin Aesthet Dermatol. 2014;7(7):19–31.
PubMed
PubMed Central
Google Scholar
Schmidt TH, Shinkai K. Evidence-based approach to cutaneous hyperandrogenism in women. J Am Acad Dermatol. 2015;73:672–90.
CAS
PubMed
Article
Google Scholar
da Cunha MG, Fonseca FL, Machado CD. Androgenic hormone profile of adult women with acne. Dermatology. 2013;226:167–71.
PubMed
Article
Google Scholar
Falsetti L, Gambera A, Andrico S, Sartori E. Acne and hirsutism in polycystic ovarian syndrome: clinical, endocrine-metabolic and ultrasonographic differences. Gynecol Endocrinol. 2002;16:275–84.
CAS
PubMed
Google Scholar
Khondker L, Khan SI. Acne vulgaris related to androgens: a review. Mymensingh Med J. 2014;23:181–5.
CAS
PubMed
Google Scholar
Bergfeld WF. The pathophysiology of acne vulgaris in children and adolescents. Part 1. Cutis. 2004;74:92–7.
PubMed
Google Scholar
Kistowska M, Meier B, Proust T, Feldmeyer L, Cozzio A, Kuendig T, et al. Propionibacterium acnes promotes Th17 and Th17/Th1 responses in acne patients. J Invest Dermatol. 2015;135:110–8.
PubMed
Article
Google Scholar
Garthwaite SM, McMahon EG. The evolution of aldosterone antagonists. Mol Cell Endocrinol. 2004;217:27–31.
CAS
PubMed
Article
Google Scholar
Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G. Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris. Int J Tissue React. 1988;10:115–9.
CAS
PubMed
Google Scholar
Akamatsu H, Zouboulis CC, Orfanos CE. Spironolactone directly inhibits proliferation of cultured human facial sebocytes and acts antagonistically to testosterone and 5-alpha dihydrotestosterone in vitro. J Invest Dermatol. 1993;100:660–2.
CAS
PubMed
Article
Google Scholar
Menard RH, Guenthner TM, Kon H, Gillette JR. Studies on the destruction of adrenal and testicular cytochrome P-450 by spironolactone. Requirement for the 7α-thio group and evidence for the loss of the heme and apoproteins of cytochrome P-450. J Biol Chem. 1979;254:1726–33.
CAS
PubMed
Google Scholar
Williams M, Cunliffe WJ. Explanation for premenstrual acne. Lancet. 1973;2:1055–7.
CAS
PubMed
Article
Google Scholar
Lam C, Zaenglein AL. Contraceptive use in acne. Clin Dermatol. 2014;32:502–15.
PubMed
Article
Google Scholar
Ganceviciene R, Zouboulis CC. Isotretinoin: state of the art treatment for acne vulgaris. J Dtsch Dermatol Ges. 2010;8(Suppl 1):47–59.
Article
Google Scholar
Del Rosso JQ, Webster GF, Rosen T, Thiboutot D, Leyden JJ, Gallo R, et al. Status report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society: Part 1. Antibiotic prescribing patterns, sources of antibiotic exposure, antibiotic consumption and emergence of antibiotic resistance, impact of alterations in antibiotic prescribing, and clinical sequelae of antibiotic use. J Clin Aesthet Dermatol. 2016;9:18–24.
Brown J, Farquhar C, Lee O, Toomath R, Jepson RG. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev. 2009;(2):CD000194.
Kim GK, Del Rosso JQ. Oral spironolactone in post-teenage female patients with acne vulgaris: practical considerations for the clinician based on current data and clinical experience. J Clin Aesthet Dermatol. 2012;5:37–50.
CAS
PubMed
PubMed Central
Google Scholar
Rayyan, the systematic reviews web app. https://rayyan.qcri.org/.Accessed 3 Nov 2106.
The Cochrane Collaboration’s tool for assessing risk of bias. In: Higgins JPT, Green S (eds). The Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011)]. The Cochrane Collaboration, 2011. www.handbook.cochrane.org. Accessed 3 Nov 2106.
Review Manager (RevMan) (computer program). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2014.
GRADE profiler version 3.6. http://tech.cochrane.org/revman/other-resources/gradepro/download. Accessed 3 Nov 2106.
Quality of evidence: In: Schünemann H, Brożek J, Oxman A (eds). GRADE: Handbook for grading quality of evidence and strength of recommendation. Updated October 2013. http://gdt.guidelinedevelopment.org/app/handbook/handbook.html. Accessed 3 Nov 2106.
Cusan L, Dupont A, Gomez JL, Tremblay RR, Labrie F. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil Steril. 1994;61:281–7.
CAS
PubMed
Article
Google Scholar
Goodfellow A, Alaghband-Zadeh J, Carter G, Cream JJ, Holland S, Scully J, et al. Oral spironolactone improves acne vulgaris and reduces sebum excretion. Br J Dermatol. 1984;111:209–14.
CAS
PubMed
Article
Google Scholar
Hagag P, Steinschneider M, Weiss M. Role of the combination spironolactone-norgestimate-estrogen in hirsute women with polycystic ovary syndrome. J Reprod Med. 2014;59:455–63.
CAS
PubMed
Google Scholar
Hatwal A, Bhatt RP, Agrawal JK, Singh G, Bajpai HS. Spironolactone and cimetidine in treatment of acne. Acta Derm Venereol. 1988;68:84–7.
CAS
PubMed
Google Scholar
Kriplani A, Thulkar J, Agrawal N, Kulshrestha V, Ammini AC, Kumar G. A comparative study of Diane-35 plus spironolactone and Diane-35 plus finasteride in cases of hirsutism and acne. Int J Endocrinol Metab. 2009;7:235–41.
CAS
Google Scholar
Leelaphiwat S, Jongwutiwes T, Lertvikool S, Tabcharoen C, Sukprasert M, Rattanasiri S, et al. Comparison of desogestrel/ethinylestradiol plus spironolactone versus cyproterone acetate/ethinylestradiol in the treatment of polycystic ovary syndrome: a randomized controlled trial. J Obstet Gynaecol Res. 2015;41:401–10.
Article
CAS
Google Scholar
Mansurul A, Islam AZM. Effect of spironolactone on acne vulgaris: a double blind study. Bangladesh J Dermatol Venereol Leprol. 2000;17:1–4.
Google Scholar
Muhlemann MF, Carter GD, Cream JJ, Wise P. Oral spironolactone: an effective treatment for acne vulgaris in women. Br J Dermatol. 1986;115:227–32.
CAS
PubMed
Article
Google Scholar
Vaswani N, Pandhi RK. Treatment of acne vulgaris with anti-androgens. Indian J Dermatol Venereol Leprol. 1990;56:34–6.
Google Scholar
Wang XM, Zhang XP, Li CH. Comparative observation on the therapeutic effect of acne vulgaris with spironolactone, ketoconazole and cimetidine. J Clin Dermatol. 1991;20:303–5.
Google Scholar
Azizlerli G, Özarmagan G, Taklifi B, Südogan S, Azizlerli H. Spironolactone therapy in acne patients [Aknede spironolatone ile tedavi]. Deri Hastalıkları ve Frengi Arşivi. 1988;22:125–9.
Google Scholar
Beksac MS, Önderglu LS, Atac B. Idiopathic hirsutism with spironolactone. Adv Contracept Deliv Syst. 1990;6:265–9.
Google Scholar
Bravo Garcia M, Barroeta S. Mejia de Alejos M, Franco de Arias M, Yustiz MA, Mascia S. Use of spironoactone in patients with acne [Uso de spironolactona en pacientes con acne]. Arch Argent Dermatol. 1987;37:231–8.
Google Scholar
Burke BM, Cunliffe WJ. Oral spironolactone therapy for female patients with acne, hirsutism or androgenic alopecia. Br J Dermatol. 1985;112:124–5.
CAS
PubMed
Article
Google Scholar
Cortez de Castro G, Pacheco A, Naranjo H, Palacios A. Spironolactone in thetreatment of acne [Espironolactona en el tratamiento del acne]. DermatologiaVenezolana. 1986;24:103–5.
Hana V, Marek J, Gregorova I. Long-term treatment of hirsutism with spironolactone [Dlouhodoba lecba hirsutismu spirolaktonem]. Casopis Lekaru Ceskych. 1984;123:1273–5.
CAS
PubMed
Google Scholar
Hughes BR, Cunliffe WJ. Tolerance of spironolactone. Br J Dermatol. 1988;118:687–91.
CAS
PubMed
Article
Google Scholar
Krunic A, Ciurea A, Scheman A. Efficacy and tolerance of acne treatment using both spironolactone and a combined contraceptive containing drospirenone. J Am Acad Dermatol. 2008;58:60–2.
PubMed
Article
Google Scholar
Lessner E, Fisher S, Kobraei K, Osleber M, Lessner R, Elliot L, et al. Spironolactone and topical retinoids in adult female cyclical acne. J Drugs Dermatol. 2014;13:126–9.
CAS
PubMed
Google Scholar
Lubbos HG, Hasinski S, Rose LI, Pollock J. Adverse effects of spironolactone therapy in women with acne. Arch Dermatol. 1998;134:1162–3.
CAS
PubMed
Article
Google Scholar
Masahashi T, Wu MC, Ohsawa M. Spironolactone therapy for hyperandrogenic anovulatory women. Clinical and endocrinological study. Acta Obstet Gynaecol Jpn. 1986;38:95–101.
Messina M, Manieri C, Biffignandi P, Massucchetti C, Novi RF, Molinatti GM. Antiandrogenic properties of spironolactone. Clinical trial in the management of female hirsutism. J Endocrinol Invest. 1983;6:23–7.
CAS
PubMed
Article
Google Scholar
Pugeat M, Elmidani M, Dechaud H, Garoscio-Cholet M, Lejeune H, Tourniaire A. Treatment of hirsutism with spironolactone and progestagen combination [Traitement de l’hirsutisme par l’association de spironolactone et d’un progestatif]. Presse Med. 1990;19:1529–32.
CAS
PubMed
Google Scholar
Plovanich M, Weng QY, Mostaghimi A. Low usefulness of potassium monitoring among healthy young women taking spironolactone for acne. JAMA Dermatol. 2015;151:941–4.
PubMed
Article
Google Scholar
Saint-Jean M, Ballanger F, Nguyen JM, Khammari A, Dréno B. Importance of spironolactone in the treatment of acne in adult women. J Eur Acad Dermatol Venereol. 2011;25:1480–1.
CAS
PubMed
Article
Google Scholar
Sato K, Matsumoto D, Iizuka F, Aiba-Kojima E, Watanabe-Ono A, Suga H, et al. Anti-androgenic therapy using oral spironolactone for acne vulgaris in Asians. Aesthet Plast Surg. 2006;30:689–94.
Article
Google Scholar
Shaw JC. Spironolactone in dermatologic therapy. J Am Acad Dermatol. 1991;24:236–43.
CAS
PubMed
Article
Google Scholar
Shaw JC. Low-dose adjunctive spironolactone in the treatment of acne in women: a retrospective analysis of 85 consecutively treated patients. J Am Acad Dermatol. 2000;43:498–502.
CAS
PubMed
Article
Google Scholar
Shaw JC, White LE. Long-term safety of spironolactone in acne: results of an 8-year follow up study. J Cutan Med Surg. 2002;6:541–5.
PubMed
Article
Google Scholar
Turowski CB, James WD. The efficacy and safety of amoxicillin, trimethoprim-sulphamethoxazole and spironolactone for treatment resistant acne vulgaris. Adv Dermatol. 2007;23:155–63.
PubMed
Article
Google Scholar
Yemisci A, Gorgulu A, Piskin S. Effects and side-effects of spironolactone therapy in women with acne. J Eur Acad DermatolVenereol. 2005;19:163–6.
CAS
Article
Google Scholar
Anonymous. Different concentrations of spironolactone in the treatment of acne. Chinese J Dermatol. 1989;22:258-9.
Azziz R, Sanchez LA, Knochenhauer ES, Moran C, Lazenby J, Stephens KC, et al. Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab. 2004;89:453–62.
CAS
PubMed
Article
Google Scholar
Devoto E, Aravena L, Rios R. Treatment of hirsutism with spironolactone and with spironolactone plus dexamethasone. Rev Med Chil. 2000;128:868–75.
CAS
PubMed
Google Scholar
Ibanez L, Diaz M, Sebastiani G, Lopez-Bermejo A, De F. Oral contraception vs low-dose pioglitazone-spironolactone-metformin for adolescent girls with hyperinsulinaemic androgen excess: on-treatment divergences. Horm Res Paediatr. 2015;84(Suppl 1):251–2.
Google Scholar
Jurzyk RS, Spielvogel RL, Rose LI. Antiandrogens in the treatment of acne and hirsutism. Am Fam Phys. 1992;45:1803–6.
CAS
Google Scholar
Karrer-Voegeli S, Rey F, Reymond MJ, Meuwly JY, Gaillard RC, Gomez F. Androgen dependence of hirsutism, acne, and alopecia in women. Retrospective analysis of 228 patients investigated for hyperandrogenism. Medicine. 2009;88:32–45.
Messina M, Manieri C, Musso MC, Pastorino R. Oral and topical spironolactone therapies in skin androgenization. Panminerva Med. 1990;32:49–55.
CAS
PubMed
Google Scholar
Molinatti GM, Messina M, Biffignandi P, Manieri C. Therapeutic possibilities in women with skin androgenic manifestations [Possibilita terapeutichein donne affette da manifestazionidi androgenizzazione a livello cutaneo]. G Ital Dermatol Venereol. 1980;115:579–84.
Google Scholar
Pizzino D, Bettoli V, Varotti C. Treatment of acne with antiandrogens: validity of treatment with spironolactone [Trattamento antiandrogeno dell’acne: validata di unaterapia con spirolattone]. G Ital DermatolVenereol. 1987;122:599–604.
CAS
Google Scholar
Shilin DE, Dedov II, Grigor’eva EA. Thetherapeuticeffect of spironolactone in the hyperandrogenism syndrome [Lechebnyi effekt spironolaktona pri sindrome giperandrogenii]. Probl Endokrinol (Mosk).1993;39:55–60.
Ylöstalo P, Heikkinen J, Kauppila A, Pakarinen A, Järvinen PA. Low-dose spironolactone in the treatment of female hirsutism. Int J Fertil. 1987;32:41–5.
PubMed
Google Scholar
Arenberger P, Vohradnikova O, Zaruba F. Treatment of acne vulgaris with spironolactone. Cesk Dermatol. 1988;63:224–7.
Google Scholar
Cortez de Castro G, Pacheco A, Naranjo H, Palacios A. Acnevulgaris: treatment with spironolactone [Acne vulgar: tratamiento con espironolactona]. Salus Militia. 1987;12:34–7.
Havrenne JED, Halbe HW. Treatment of idiopathic hirsutism with spironolactone [Tratamento do hirsutismo idiopático com espironolactona]. Ginecol Obstet Bras. 1985;8:73–4.
Google Scholar
Vohradnikova O, Arenberger P, Kratochvilova M, Zaruba F. Treatment of acne vulgaris with spironolactone and Androcur. Cesk Dermatol. 1988;63:308–10.
Google Scholar
Yemisci A, Gorgulu A, Piskin S. Spironolactone therapy in acne vulgaris [Acne vulgaris tedavisinde spironolakton]. Türkderm Deri Hastaliklari ve Frengi Arivi. 1994;28:209–12.
Google Scholar
Cremoncini C, Vignati E, Libroia A. Treatment of hirsutism and acne in women with two combinations of cyproterone acetate and ethinylestradiol. Acta Eur Fertil. 1976;7:299–314.
CAS
PubMed
Google Scholar
Michaëlsson G, Juhlin L, Vahlquist A. Effects of oral zinc and vitamin A in acne. Arch Dermatol. 1977;113:31–6.
PubMed
Article
Google Scholar
Adityan B, Thappa DM. Profile of acne vulgaris: a hospital-based study from South India. Indian J Dermatol Venereol Leprol. 2009;75:272–8.
PubMed
Article
Google Scholar
Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997;36:416–8.
CAS
PubMed
Article
Google Scholar
Burke BM, Cunliffe WJ. The assessment of acne vulgaris: the Leeds technique. Br J Dermatol. 1984;111:83–92.
CAS
PubMed
Article
Google Scholar
Caron P, Chateauneuf C, Bazex J, Louvet JP. Anti-seborrhea effect of cimetidine [Effet anti-séborrhée de cimétidine]. Bio Med Pharmacother. 1987;41:253–4.
CAS
Google Scholar
Arowojolu AO, Gallo MF, Lopez LM, Grimes DA. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev. 2012;(7):CD004425.
Jones H, Simpson NB, Blanc D, Forster RA, Cunliffe WJ. Lack of effect of cimetidine in acne. Lancet. 1980;2(8205):1201–2.
CAS
PubMed
Article
Google Scholar
Wang HS, Wang TH, Soong YK. Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea. Changgeng Yi Xue Za Zhi. 1999;22:423–32.
CAS
PubMed
Google Scholar
Calaf J, Lopez E, Millet A, Alcañiz J, Fortuny A, Vidal O, et al. Long term efficacy and tolerability of flutamide compared with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial. J Clin Endocrinol Metab. 2007;92:3446–50.
CAS
PubMed
Article
Google Scholar
Adalatkhah H, Pourfarzi F, Sadeghi-Bazargani H. Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial. Clin Cosmet Investig Dermatol. 2011;4:117–21.
CAS
PubMed
PubMed Central
Article
Google Scholar
Carmina E, Lobo RA. A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women. Clin Endocrinol (Oxf). 2002;57:231–4.
CAS
PubMed
Article
Google Scholar
Kohler C, Tschumi K, Bodmer C, et al. Effect of finasteride 5 mg (Proscar) on acne and alopecia in female patients with normal serum levels of free testosterone. Gynecol Endocrinol. 2007;23:142–5.
CAS
PubMed
Article
Google Scholar
Venturoli S, Fabbri R, Dal Prato L, Mantovani B, Capelli M, Magrini O, et al. Ketoconazole therapy for women with acne and/or hirsutism. J Clin Endocrinol Metab. 1990;71:335–9.
CAS
PubMed
Article
Google Scholar
Vidal-Puig AJ, Muñoz-Torres M, Jódar-Gimeno E, García-Calvente CJ, Lardelli P, Ruiz-Requena ME, et al. Ketoconazole therapy: hormonal and clinical effects in non-tumoral hyperandrogenism. Eur J Endocrinol. 1994;130:333–8.
CAS
PubMed
Article
Google Scholar
Ghetti P, Patrone P, Tosti A. Ketoconazole in the treatment of acne in women. Arch Dermatol. 1986;122(6):629.
CAS
PubMed
Article
Google Scholar
Lyons F, Cook J, Shuster S. Inhibition of sebum secretion by an H2 blocker. Lancet. 1979;1(8131):1376.
CAS
PubMed
Article
Google Scholar
Erkkola R, Hirvonen E, Luikku J, Lumme R, Mannikko H, Aydinlik S. Ovulation inhibitors containing cyproterone acetate or desogestrel in the treatment of hyperandrogenic symptoms. Acta Obstet Gynecol Scand. 1990;69:61–5.
CAS
PubMed
Article
Google Scholar
Falsetti L, Galbignani E. Long-term treatment with the combination ethinylestradiol and cyproterone acetate in polycystic ovary syndrome. Contraception. 1990;42:611–9.
CAS
PubMed
Article
Google Scholar
Greenwood R, Brummitt L, Burke B, Cunliffe WJ. Acne: double blind clinical and laboratory trial of tetracycline, oestrogen-cyproterone acetate, and combined treatment. Br Med J (Clin Res Ed). 1985;291:1231–5.
CAS
Article
Google Scholar
Miller JA, Wojnarowska FT, Dowd PM. Anti-androgen treatment in women with acne: a controlled trial. Br J Dermatol. 1986;114:705–16.
CAS
PubMed
Article
Google Scholar
vanVloten WA, van Haselen CW, van Zuuren EJ, Gerlinger C, Heithecker R. The effect of 2 combined oral contraceptives containing either drospirenone or cyproterone acetate on acne and seborrhea. Cutis. 2002;69(4 Suppl):2–15.
Huber J, Foidart JM, Wuttke W, Merki-Feld GS, The HS, Gerlinger C, et al. Efficacy and tolerability of a monophasic oral contraceptive containing ethinylestradiol and drospirenone. Eur J Contracept Reprod Health Care. 2000;5:25–34.
CAS
PubMed
Article
Google Scholar
Jaisamrarn U, Chaovisitsaree S, Angsuwathana S, Nerapusee O. A comparison of multiphasic oral contraceptives containing norgestimate or desogestrel in acne treatment: a randomized trial. Contraception. 2014;90:535–41.
CAS
PubMed
Article
Google Scholar
Katz HI, Kempers S, Akin MD, Dunlap F, Whiting D, Norbart TC. Effect of a desogestrel-containing oral contraceptive on the skin. Eur J Contracept Reprod Health Care. 2000;5:248–55.
CAS
PubMed
Article
Google Scholar
Kränzlin HT, Nap MA. The effect of a phasic oral contraceptive containing desogestrel on seborrhea and acne. Eur J Contracept Reprod Health Care. 2006;11:6–13.
PubMed
Article
CAS
Google Scholar
Prilepskaya VN, Serov VN, Zharov EV, Golousenko IJ, Mejevitinova EA, Gogaeva EV, et al. Effects of a phasic oral contraceptive containing desogestrel on facial seborrhea and acne. Contraception. 2003;68:239–45.
CAS
PubMed
Article
Google Scholar
Thorneycroft IH, Gollnick H, Schellschmidt I. Superiority of a combined contraceptive containing drospirenone to a triphasic preparation containing norgestimate in acne treatment. Cutis. 2004;74:123–30.
PubMed
Google Scholar
De Pedrini P, Rapisarda R, Spanò G. The effect of ketoconazole on sebum secretion in patients suffering from acne and seborrhea. Int J Tissue React. 1988;10:111–3.
PubMed
Google Scholar
Norris JF, Cunliffe WJ. Effect of ketoconazole on sebum excretion rate. Arch Dermatol. 1987;123:301.
CAS
PubMed
Article
Google Scholar
Schmidt JB. Other antiandrogens. Dermatology. 1998;196:153–7.
CAS
PubMed
Article
Google Scholar
Carr BR. Uniqueness of contraceptive progestins. Contraception. 1998;58(3 Suppl):23–7.
Article
Google Scholar
del Marmol V, Teichmann A, Gertsen K. The role of combined oral contraceptives in the management of acne and seborrhea. Eur J Contracept Reprod Health Care. 2004;9:107–24.
PubMed
Article
CAS
Google Scholar
Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, et al. Classification and pharmacology of progestins. Maturitas. 2008;61:171–80.
PubMed
Article
Google Scholar
Friedman. Spironolactone for adult female acne. Cutis. 2015;96:216–7.
Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74:945–73.
PubMed
Article
Google Scholar
Dréno B, Thiboutot D, Layton AM, Berson D, Perez M, Kang S, Global Alliance to Improve Outcomes in Acne. Large-scale international study enhances understanding of an emerging acne population: adult females. J Eur Acad Dermatol Venereol. 2015;29:1096–106.
PubMed
Article
CAS
Google Scholar
Danby FW. Spironolactone. J Am Acad Dermatol. 1992;26:137.
CAS
PubMed
Article
Google Scholar
Bettoli V, Zauli S, Virgili A. Is hormonal treatment still an option in acne today. Br J Dermatol. 2015;172(Suppl 1):37–46.
CAS
PubMed
Article
Google Scholar
Del Rosso JQ, Harper JC, Graber EM, Thiboutot D, Silverberg NB, Eichenfield DZ, et al. Status report from the American Acne & Rosacea Society on medical management of acne in adult women, part 1: overview, clinical characteristics, and laboratory evaluation. Cutis. 2015;96:236–41.
PubMed
Google Scholar
Gollnick HP, Bettoli V, Lambert J, Araviiskaia E, Binic I, Dessinioti C, et al. A consensus-based practical and daily guide for the treatment of acne patients. J Eur Acad Dermatol Venereol. 2016;30:1480–90.
CAS
PubMed
Article
Google Scholar
Nast A, Dreno B, Bettoli V, Bukvic Mokos Z, Degitz K, Dressler C, et al. European evidence-based (S3) guideline for the treatment of acne—update 2016—short version. J Eur Acad Dermatol Venereol. 2016;30:1261–8.
CAS
PubMed
Article
Google Scholar
NICE Clinical Knowledge Summary. Acne 2014. cks.nice.org.uk/acne-vulgaris. Accessed 3 Nov 2016 (not available outside the UK).
Abad-Casintahan F, Chow SK, Goh CL, Kubba R, Miyachi Y, Noppakun N, et al. Toward evidence-based practice in acne: consensus of an Asian Working Group. J Dermatol. 2011;38:1041–8.
PubMed
Article
Google Scholar
Goh CL, Abad-Casintahan F, Aw DC, Baba R, Chan LC, Hung NT, et al. South-East Asia study alliance guidelines on the management of acne vulgaris in South-East Asian patients. J Dermatol. 2015;42:945–53.
PubMed
Article
Google Scholar
CPG Secretariat. Management of acne. Malaysian clinical practice guideline 2012. http://www.moh.gov.my/attachments/7190.pdf. Accessed 3 Nov 2016.
Nast A, Bayerl C, Borelli C, et al. S2 k-guideline for therapy of acne [in German]. J Dtsch Dermatol Ges. 2010;8(Suppl 2):1–59.
Google Scholar
Asai Y, Baibergenova A, Dutil M, et al. Management of acne: Canadian clinical practice guideline. Can Med Assoc J. 2016;188:118–26.
Article
Google Scholar
Brown P, Brunnhuber K, Chalkidou K, Chalmers I, Clarke M, Fenton M. How to formulate research recommendations. BMJ. 2006;333:804–6.
PubMed
PubMed Central
Article
Google Scholar