Platelet-rich plasma (PRP) is a solution derived from whole blood that is enriched in the platelet fraction. Platelets serve as a reservoir of growth factors and cytokines. When platelets are activated in vivo, signaling molecules are released into the immediate microenvironment and activate receptors for various pathways. Historically, PRP has been applied to wound beds to promote healing of complex wounds. Over the last decade, it has served as a valuable therapeutic tool in various specialties such as maxillofacial surgery, plastic surgery, orthopedics and sports medicine. Only recently has PRP been utilized for dermatologic purposes, more specifically, for the treatment of male and female pattern hair loss. In this review, we discuss molecular and cellular pathways upregulated by PRP important in hair folliculogenesis, and examine clinical evidence from all previously published studies involving the use of PRP for pattern hair loss.
Hair Follicle Finasteride Hair Loss Pyoderma Gangrenosum Dermal Papilla
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The authors would like to thank Nicole Rogers, MD, FAAD, FISHRS for providing the sample protocol and the clinical photographs.
Compliance with Ethical Standards
No funding was received for the preparation of this review.
Conflict of interest
Babu Singh and Lynne J. Goldberg have no conflicts of interest to declare.
Carter MJ, Fylling CP, Parnell LK. Use of Platelet rich plasma gel on wound healing: a systematic review and meta-analysis. Eplasty. 2011;11:e38.PubMedPubMedCentralGoogle Scholar
Sommeling CE, Heyneman A, Hoeksema H, et al. The use of platelet-rick plasma in plastic surgery: a systematic review. J Plast Reconstr Aesthet Surg. 2013;66:301–12.CrossRefPubMedGoogle Scholar
Curi MM, Cossolin GS, Koga DH, et al. Treatment of avascular osteonecrosis of the jaw in cancer patients with a history of bisphosphonate therapy by combining bone resection and autologous platelet-rich plasma: report of 3 cases. J Oral Maxillofac Sug. 2007;65:348–55.Google Scholar
Ronci C, Ferraro AS, Lanti A, et al. Platelet-rich plasma as treatment for persistent ocular epithelial defects. Transfus Apheres Sci. 2015;52(3):300–4.CrossRefGoogle Scholar
Uebel CO, da Silva JB, Cantarelli D, et al. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. 2006;118(6):1458–66.CrossRefPubMedGoogle Scholar
Cayirh M, Cahskan E, Acikgoz G, et al. Regression of melisma with platelet-rich plasma treatment. Ann Dermatol. 2014;26(3):401–2.CrossRefGoogle Scholar
Conde-Montero E, Horcajada-Reales C, Clavo P, et al. Neuropathic ulcers in leprosy treated with intralesional platelet-rich plasma. Int Wound J. 2014. doi:10.1111/iwj.12359.PubMedGoogle Scholar
Motolese A, Vignati F, Antelmi A, et al. Effectiveness of platelet-rich plasma in healing necrobiosis lipoidica diabeticorum ulcers. Clin Exp Dermatol. 2015;40(1):39–41.CrossRefPubMedGoogle Scholar
Casabona F, Priano V, Vallerino V, et al. New surgical approach to lichen sclerosis of the vulva: the role of adipose-derived mesenchymal cells and platelet-rich plasma in tissue regeneration. Plast Reconstr Surg. 2010;126(4):210e–211e.CrossRefPubMedGoogle Scholar
Budamakuntla L, Suryanarayan S, Sarvajnamurthy SS, et al. Autologous platelet rich plasma in pyoderma gangrenosum—two case reports. Indian J Dermatol. 2015;60(2):204–5.CrossRefPubMedPubMedCentralGoogle Scholar
Cervelli V, Garcovich S, Bielli A, et al. The effect of autologous activated platelet right plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int. 2014. doi:10.1155/2014/760709.Google Scholar
Gkini MA, Kouskoukis AE, Tripsianis G, et al. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg. 2014;7(4):213–9.CrossRefPubMedPubMedCentralGoogle Scholar
Kang JS, Zheng Z, Choi MJ, et al. The effect of CD34+ cell-combining autologous platelet rich plasma injection on pattern hair loss: a preliminary study. JEADV. 2014;28:72–9.PubMedGoogle Scholar
Schiavone G, Raskovic D, Greco J, et al. Platelet-rich plasma for androgenetic alopecia: a pilot study. Dermatol Surg. 2014;40(9):1010–9.CrossRefPubMedGoogle Scholar
Betsi EE, Germain E, Kalbermatten DF, et al. Platelet-rich plasma injection is effective and safe for the treatment of alopecia. Eur J Plast Surg. 2013;36:407–12.CrossRefGoogle Scholar
Takikawa M, Nakamura S, Nakamura S, et al. Enhanced effect of platelet-rich plasma containing a new carrier on hair growth. Dermatol Surg. 2011;37(12):1721–9.CrossRefPubMedGoogle Scholar
Amable PR, Carias PB, Teixeira MV, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Therapy. 2013;4:67.CrossRefGoogle Scholar
Giusti I, Rughetti A, D’Ascenzo S, et al. Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion. 2009;49:771–8.CrossRefPubMedGoogle Scholar