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Platelet-Rich Plasma for Hair Loss

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Platelet-Rich Plasma in Dermatologic Practice

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Abstract

Platelet-rich plasma (PRP) is a promising alternative to traditional hair loss therapies such as minoxidil and finasteride. By discharging growth factors and cytokines, PRP can promote cell survival, growth, and proliferation. In recently conducted meta-analyses, PRP treatments have reported a greater efficacy over placebo in terms of mean change in hair density in androgenetic alopecia (AGA) patients. PRP has also induced significantly more hair regrowth in alopecia areata (AA) patients as compared to placebo and has increased follicular yields when incorporated into hair restoration procedures. Despite the various PRP protocols and techniques investigated, the main determinant of a successful PRP solution is its contents. Effective PRP solutions should be free of red and white blood cells and have elevated levels of stimulating growth factors, cytokines, and platelets.

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Abbreviations

AA:

Alopecia areata

AGA:

Androgenetic alopecia

CA:

Cicatricial alopecia

DHT:

Dihydrotestosterone

EGF:

Epidermal growth factor

FGF:

Fibroblast growth factor

IGF:

Insulin-like growth factor

NGF:

Nerve growth factor

PDGF:

Platelet-derived growth factors

PRP:

Platelet-rich plasma

TGF:

Transforming growth factor

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Toronto, ON, Canada

    Aditya K. Gupta

  2. Mediprobe Research Inc., London, ON, Canada

    Aditya K. Gupta & Sarah G. Versteeg

  3. Cosmetic Skin and Surgery Center, Englewood Cliffs, NJ, USA

    Jeffrey A. Rapaport

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  1. Aditya K. Gupta
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  2. Jeffrey A. Rapaport
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  3. Sarah G. Versteeg
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Correspondence to Aditya K. Gupta .

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Editors and Affiliations

  1. Department of Dermatology, Weill Medical College of Cornell University, New York, NY, USA

    Neil S. Sadick

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Gupta, A.K., Rapaport, J.A., Versteeg, S.G. (2021). Platelet-Rich Plasma for Hair Loss. In: Sadick, N.S. (eds) Platelet-Rich Plasma in Dermatologic Practice. Springer, Cham. https://doi.org/10.1007/978-3-030-66230-1_5

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