Abstract
Since sulfonylurea is one of the most potent acetohydroxyacid synthase(AHAS) inhibitors, a series of novel sulfonylureas containing an oxime ether moiety was designed and synthesized and their chemical structures were determined by means of 1H nuclear magnetic resonance(NMR), 13C NMR and high-resolution mass spectrometry( HRMS). In the herbicidal bioassay, several compounds showed moderate to good herbicidal activities against dicotyledons, but their activities against monocotyledons decreased. The in vitro antifungal activity was tested at a dosage of 50 mg/L. And the results show that compounds 7l, 7m and 7n exhibit promising antifungal activities against six common plant pathogenic fungi. Further investigations on molecular modification are in progress.
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Supported by the National Natural Science Foundation of China(No.21272129), the National Key Technology Research and Development Program of China(No.2011BAE06B05), the “111” Project of the Ministry of Education of China(No.B06005) and the Project of the Synergetic Innovation Center of Chemical Science and Engineering of Tianjin, China.
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Wei, W., Cheng, D., Chen, W. et al. Design, syntheses and biological activities of novel sulfonylureas containing an oxime ether moiety. Chem. Res. Chin. Univ. 32, 195–201 (2016). https://doi.org/10.1007/s40242-016-5406-1
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DOI: https://doi.org/10.1007/s40242-016-5406-1