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Synthesis and evaluation of novel N-(4′-arylpyrimidin-2′-yl) sulfonylurea derivatives as potential antifungal agents

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Chemical Research in Chinese Universities Aims and scope

Abstract

Sulfonylureas(SUs) are potent and selective inhibitors of acetohydroxyacid synthase and has been used as herbicides. Some SUs also displayed other biological activities. In order to discuss the antifungal activity of SUs, a series of novel SUs containing aryl-substituted pyrimidine moieties was designed and synthesized. The preliminary bioassay showed that the title compounds exhibited moderate to favorable fungicidal activities in vivo. Especially, compound 9b exhibited more efficacy than the controls against five fungi at 25 mg/L. These promising results indicate that an aryl group on pyrimidine ring is favorable for antifungal activity and SUs are potential inhibitors for some phytopathogenic fungi.

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Authors and Affiliations

  1. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China

    Wei Chen, Yuxin Li, Wei Wei, Youwei Chen, Yonghong Li, Jingbo Liu & Zhengming Li

  2. Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Nankai University, Tianjin, 300071, P. R. China

    Wei Chen, Yuxin Li, Wei Wei, Youwei Chen, Jingbo Liu & Zhengming Li

  3. Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, P. R. China

    Yanxia Shi & Baoju Li

Authors
  1. Wei Chen
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  2. Yuxin Li
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  3. Yanxia Shi
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  4. Wei Wei
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  5. Youwei Chen
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  6. Yonghong Li
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  7. Jingbo Liu
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  8. Baoju Li
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  9. Zhengming Li
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Corresponding authors

Correspondence to Baoju Li or Zhengming Li.

Additional information

Supported by the National Natural Science Foundation of China(No.21272129) and the National Key Technologies R&D Program of China(No.2011BAE06B05).

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Chen, W., Li, Y., Shi, Y. et al. Synthesis and evaluation of novel N-(4′-arylpyrimidin-2′-yl) sulfonylurea derivatives as potential antifungal agents. Chem. Res. Chin. Univ. 31, 218–223 (2015). https://doi.org/10.1007/s40242-015-4362-5

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  • DOI: https://doi.org/10.1007/s40242-015-4362-5

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