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Design, synthesis and activities of aziridine derivatives of N5-methyltetrahydrofolate against methionine synthase

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Abstract

Aziridine derivatives of N5-methyltetrahydrofolate were designed and synthesized based on the mechanism of methionine synthase, and their biological activities were investigated as well. The aziridine derivatives 1 and 6 exhibited superior inhibitory activities(IC50: 5.05 and 4.15 µmol/L, respectively) compared to the corresponding chain analogue 4(IC50=24.42 µmol/L). The results suggest that the aziridine derivatives can get potential activities against nucleophilic methionine synthase.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Peking University, Beijing, 100191, P. R. China

    Xiling Deng, Ying Guo, Chao Tian, Junyi Liu, Xiaowei Wang & Zhili Zhang

  2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China

    Junyi Liu

  3. School of Pharmaceutical Sciences, Shihezi University, Shihezi, 832000, P. R. China

    Xiling Deng

Authors
  1. Xiling Deng
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  2. Ying Guo
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  3. Chao Tian
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  4. Junyi Liu
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  5. Xiaowei Wang
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  6. Zhili Zhang
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Corresponding author

Correspondence to Zhili Zhang.

Additional information

Supported by the National Natural Science Foundation of China(No.21172014).

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Deng, X., Guo, Y., Tian, C. et al. Design, synthesis and activities of aziridine derivatives of N5-methyltetrahydrofolate against methionine synthase. Chem. Res. Chin. Univ. 31, 742–745 (2015). https://doi.org/10.1007/s40242-015-5194-z

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  • DOI: https://doi.org/10.1007/s40242-015-5194-z

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