Abstract
A novel phenanthrene imine was synthesized from 9,10-phenanthrenequinone, 1,4-diazabicyclo octane (Dabco), 2,6-dimethylaniline, 2,6-diisopropylaniline and TiCl4 via standard Schlenk and vacuum-line or glovebox techniques. 3-(4,5-Dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide(MTT) assay and flow cytometry(FCM) were used to detect the activities of the compound to kill tumor cells and the mechanisms of action were investigated in the study. The results show that the compound is active in killing tumor cells. Mechanistic investigations found that the compound could induce apoptosis of tumor cells.
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Supported by the Foundation of Science and Technology of Jilin Province, China(No.201015186).
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Wang, Xd., Jin, Lm., Sun, Z. et al. Activities of a novel phenanthrene imine to kill tumor cells. Chem. Res. Chin. Univ. 29, 721–723 (2013). https://doi.org/10.1007/s40242-013-3250-0
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DOI: https://doi.org/10.1007/s40242-013-3250-0