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Easily accessible and highly selective “Turn-on” fluorescent sensor for imaging cadmium in living cells

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Abstract

A new schiff base of phenothiazine derivative was designed for ratiometric sensing of Cd2+ selectively. Upon the addition of Cd2+ to the solution of phenothiazine derivative, the fluorescence intensity of it was enhanced in a linear fashion and the maximum fluorescence peak exhibited a blue shift from 575 nm to 525 nm. This ratiometric fluorescent sensor displays a very high sensitivity(detection limits were 0.34 and 1.0 μmol/L of Cd2+ using the visual fluorescence changes and UV-Vis changes, respectively), a rapid response time(<10 s) and high selectivity for Cd2+ over other transition metal ions. Moreover, the living cells image experiments also demonstrate the value of the sensor in fluorescent visualization of Cd2+ in the environmental and biological systems.

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Authors and Affiliations

  1. Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, 130031, P. R. China

    Wei Wang & Qing Zhao

  2. College of Chemistry, Jilin University, Changchun, 130012, P. R. China

    Wei Wang, Ying-mu Zhang & Yao-xian Li

Authors
  1. Wei Wang
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  2. Ying-mu Zhang
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  3. Yao-xian Li
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  4. Qing Zhao
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Correspondence to Qing Zhao.

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Wang, W., Zhang, Ym., Li, Yx. et al. Easily accessible and highly selective “Turn-on” fluorescent sensor for imaging cadmium in living cells. Chem. Res. Chin. Univ. 29, 632–637 (2013). https://doi.org/10.1007/s40242-013-3126-3

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  • DOI: https://doi.org/10.1007/s40242-013-3126-3

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