Abstract
A Lantana camara leaf (LC) extract was used as a mild reducing agent to produce silver metal nanoparticles (LC-AgNPs) efficiently. The size, shape, and morphology of synthesized silver nanoparticles were verified. LC-AgNPs were found in LC extract by XRD. The optimal concentrations of silver nitrate and LC extract necessary for the production of stable silver nanoparticles were determined. The LC-AgNPs were found spherical in form and monodispersed. Under optimal conditions, the round LC-AgNPs of 50–90 nm were utilized to cure lung cancer (A549 cell line) and breast cancer (MCF7) cell lines. Finally, the produced LC-AgNPs enhanced anti-cancer efficacy against A549 cells, with an IC50 = 49.52 g/mL. Similarly, the effect of LC-AgNPs on MCF7 cell line was assessed using an MTT test and inhibitory concentration (IC50) was determined found that 46.67 g/mL.
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Hublikar, L.V., Ganachari, S.V., Patil, V.B. et al. Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract. Prog Biomater 12, 155–169 (2023). https://doi.org/10.1007/s40204-023-00219-9
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DOI: https://doi.org/10.1007/s40204-023-00219-9