Abstract
Purpose
Endocrinology and Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, has achieved many advances in the understanding of epidemiology, pathology, and molecular biology of thyroid cancer (TC). This paper will focus on published literature in the field of TC research at EMRI since its inception.
Methods
A comprehensive literature search of “Scopus”, “Web of Science (ISI)”, “PubMed”, and “SID” databases was done to identify TC-based studies in EMRI since 2005, using the predefined keywords.
Results
All the records were reviewed. Eventually, 46 articles that met the inclusion and exclusion criteria were considered. Timeline, characteristics, and summarized findings of the included most studies have been briefly described.
Conclusion
The main focus of the TC research at EMRI is to investigate genetic and epigenetic changes as well as the cellular and molecular aspects seen more frequently in TC patients, and find out how exactly these alterations lead to more aggressive TC behavior and resistance to the conventional treatment approaches in those patients.
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Abbreviations
- 1H-NMR:
-
hydrogen-1 nuclear magnetic resonance
- 3D:
-
three-dimensional
- ABC:
-
ATP binding cassette
- AGREE:
-
Appraisal of Guidelines Research and Evaluation
- ATC:
-
anaplastic thyroid carcinoma
- BRAF:
-
v-Raf murine sarcoma viral oncogene homolog B
- CASC2:
-
cancer susceptibility candidate 2
- CDH1:
-
cadherin 1
- cfDNA:
-
circulating cell-free DNA
- CFSE:
-
5,6-carboxyfluorescein N-hydroxysuccinimidyl ester
- CSC:
-
cancer stem cell
- ctDNA:
-
circulating tumor DNA
- Ci:
-
cuire
- DAPK:
-
death associated protein kinase
- DNMT1:
-
DNA methyltransferase 1
- DTC:
-
differentiated thyroid cancer
- EGFRvIII:
-
epithelial growth factor receptor variant III
- EMRI:
-
endocrinology and metabolism research institute
- FSCN1:
-
fascin actin-bundling protein 1
- FTA:
-
follicular thyroid adenoma
- FTC:
-
follicular thyroid carcinoma
- GAS5:
-
growth arrest special 5
- GBq:
-
gigabecquerel
- GM:
-
gut microbiome
- HLA-C:
-
major histocompatibility complex class I C
- HLA-DR:
-
major histocompatibility complex class II DR
- HLA-DRB1:
-
major histocompatibility complex class II DR beta1
- HOTAIRM1:
-
HOX antisense intergenic RNA myeloid 1
- IHC:
-
immunohistochemical
- I− :
-
iodine
- LncRNA:
-
long non-coding RNA
- IRMA:
-
immunoradiometric assay
- Klhl14:
-
kelch like family member 14
- MACS:
-
magnetic-activated cell sorting
- MALAT1:
-
metastasis associated lung adenocarcionoma transcript 1
- MEK:
-
mitogen-activated protein kinase kinase 1
- MEN 2A:
-
multiple endocrine neoplasia type 2A
- MGMT:
-
O-6-methylguanine-DNA methyltransferase
- MIR22HG:
-
MIR22 host gene
- miRNA:
-
micro RNA
- MMP-2:
-
matrix metallopeptidase 2
- MRI:
-
magnetic resonance imaging
- MS-HRM:
-
methylation-sensitive high resolution melting
- MTC:
-
medullary thyroid carcinoma
- NIS:
-
sodium/iodide symporter
- P16:
-
cyclin dependent kinase inhibitor 2A
- P53:
-
tumor protein P53
- PPARγ:
-
peroxisome proliferator activated receptor gamma
- PCA3:
-
prostate cancer antigen 3
- PTC:
-
papillary thyroid carcinoma
- PTEN:
-
phosphatase and tensin homolog
- RAI:
-
radioiodine
- RAIR:
-
radioiodine-refractory
- RAIR-DTC:
-
radioiodine-refractory differentiated thyroid cancer
- RARβ2:
-
retinoic acid receptor beta
- RASSF1A:
-
Ras association domain family member 1
- RFLP:
-
restriction fragment length polymorphism
- qRT-PCR:
-
quantitative real-time polymerase chain reaction; RAS association domain family member 1
- RET:
-
ret. proto-oncogene
- SLC5A8:
-
solute carrier family 5 member 8
- TC:
-
thyroid cancer
- TSH:
-
thyroid-stimulating hormone
- TSHR:
-
thyroid-stimulating hormone receptor.
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Acknowledgements
In Memory of Professor Mohammad Hasan Bastan Hagh.
Prof. Mohammad Hasan Bastan Hagh was the founder of the Thyroid Research Group of Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences and left long-lasting scientific attainments.
May his soul rest in peace and he will be cherished in our memories forever.
The authors would like to thanks Dr. Mahmood Naderi for his helpful suggestions and advice. Also, the authors are grateful to Ms. Rasha Atlasi for literature search.
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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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Samimi, H., Shirzad, N., Sajjadi-Jazi, S.M. et al. Thyroid Cancer research at endocrinology and metabolism research institute (EMRI): a report of scientific activities between 2005 and 2020. J Diabetes Metab Disord (2021). https://doi.org/10.1007/s40200-020-00702-1
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DOI: https://doi.org/10.1007/s40200-020-00702-1