Tissue-specific patterns of gene expression are fundamental to establishing and preserving tissue identity and function, and dysregulation of these patterns underlies a wide range of diseases. Over the past few years, several large-scale efforts driven by the advent of RNA sequencing have established resources of gene expression measurements, across both tissues and individuals, toward building a comprehensive understanding of the specificity and variability of gene expression. We summarize these resources, review insights gained into the tissue specificity of gene expression across transcript classes, including protein-coding and non-coding RNAs, and discuss the developments that will be needed to integrate existing and new resources into a detailed map of gene expression and its regulation across the human body.
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Conflict of Interest
François Aguet and Kristin G. Ardlie declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
This article is part of the Topical collection on Genomics.
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Aguet, F., Ardlie, K.G. Tissue Specificity of Gene Expression. Curr Genet Med Rep 4, 163–169 (2016). https://doi.org/10.1007/s40142-016-0105-2
- Gene expression
- Tissue specificity
- Human transcriptome
- Genomic resources