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Ng KT, Van Paassen J, Langan C, Sarode DP, Arbous MS, Alston RP, et al. The efficacy and safety of prophylactic corticosteroids for the prevention of adverse outcomes in patients undergoing heart surgery using cardiopulmonary bypass: a systematic review and meta-analysis of randomized controlled trials. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2020;57(4):620–7 This systematic review and meta-analysis updates the reader on the recently published literature. The authors suggested that corticosteroids during cardiac surgeries did not affect mortality rate but reduced pulmonary adverse events.
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Dvirnik N, Belley-Cote EP, Hanif H, Devereaux PJ, Lamy A, Dieleman JM, et al. Steroids in cardiac surgery: a systematic review and meta-analysis. British journal of anaesthesia. 2018;120(4):657–67 This review article summarized the effects of perioperative corticosteroid administration. The authors suggested an unclear impact on mortality and an increased risk of myocardial injury with the perioperative administration of corticosteroids.
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Dieleman JM, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, et al. Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial. JAMA. 2012;308(17):1761–7 The DECS trial published in 2012 is one of two large randomized clinical trials that mainly influences the ongoing research and discussion regarding the use of perioperative corticosteroids in cardiac surgery. The authors summarized that the perioperative administration of dexamethasone was associated with a decreased incidence of postoperative infection, duration of mechanical ventilation, and length of ICU and hospital stay and had beneficial effects on respiratory complications.
Whitlock RP, Devereaux PJ, Teoh KH, Lamy A, Vincent J, Pogue J, et al. Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial. Lancet. 2015;386(10000):1243–53 The SIRS trial published in 2015 is one of the large clinical studies regarding the perioperative use of corticosteroids. The authors concluded that methylprednisolone did not have a significant effect on mortality or major morbidity after cardiac surgery with cardiopulmonary bypass but suggested an increased risk of myocardial injury.
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