Deyo RA, Weinstein JN. Low back pain. N Engl J Med. 2001;344(5):363–70.
CAS
PubMed
Google Scholar
Chou R, Qaseem A, Owens DK, Shekelle P, Clinical Guidelines Committee of the American College of Physicians. Diagnostic imaging for low back pain: advice for high-value health care from the American College of Physicians. Ann Intern Med. 2011;154(3):181.
PubMed
Google Scholar
Chou R, Qaseem A, Snow V, Casey D, Cross JT, Shekelle P, et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med. 2007;147(7):478.
PubMed
Google Scholar
DePalma MJ, Ketchum JM, Saullo T. What is the source of chronic low back pain and does age play a role? Pain Med. 2011;12(2):224–33.
PubMed
Google Scholar
Schwarzer AC, Aprill CN, Derby R, Fortin J, Kine G. The relative contributions of the disc and zygapophyseal joint in chronic low back pain. Spine (Phila Pa 1976). 1994;19(7):801–6.
CAS
Google Scholar
Manchikanti L, Singh V. Evaluation of the relative contributions of various structures in chronic low back pain. Pain Phys. 2001;4:308–16.
CAS
Google Scholar
Fagan A, Moore R, Vernon Roberts B, Blumbergs P, Fraser R. ISSLS prize winner: the innervation of the intervertebral disc: a quantitative analysis. Spine (Phila Pa 1976). 2003;28(23):2570–6.
Google Scholar
Van Dieën JH, Weinans H, Toussaint HM. Fractures of the lumbar vertebral endplate in the etiology of low back pain: a hypothesis on the causative role of spinal compression in aspecific low back pain. Med Hypotheses. 1999;53(3):246–52.
PubMed
Google Scholar
Lotz JC, Fields AJ, Liebenberg EC. The role of the vertebral end plate in low back pain. Glob Spine J. 2013;3(3):153–63.
CAS
Google Scholar
Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC. Pathobiology of Modic changes. Eur Spine J. 2016;25(11):3723–34.
PubMed
Google Scholar
Dudli S, Sing DC, Hu SS, Berven SH, Burch S, Deviren V, et al. ISSLS PRIZE IN BASIC SCIENCE 2017: intervertebral disc/bone marrow cross-talk with Modic changes. Eur Spine J. 2017;26(5):1362–73.
PubMed
Google Scholar
Bailey JF, Liebenberg E, Degmetich S, Lotz JC. Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra. J Anat. 2011;218(3):263–70.
PubMed
PubMed Central
Google Scholar
Fras C, Kravetz P, Mody DR, Heggeness MH. Substance P-containing nerves within the human vertebral body: an immunohistochemical study of the basivertebral nerve. Spine J. 2003;3(1):63–7.
PubMed
Google Scholar
Ulrich JA, Liebenberg EC, Thuillier DU, Lotz JC. ISSLS prize winner: repeated disc injury causes persistent inflammation. Spine (Phila Pa 1976). 2007;32(25):2812–9.
Google Scholar
Kjaer P, Korsholm L, Bendix T, Sorensen JS, Leboeuf-Yde C. Modic changes and their associations with clinical findings. Eur Spine J. 2006;15(9):1312–9.
PubMed
PubMed Central
Google Scholar
Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C. Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine J. 2008;17:1407–22.
PubMed
PubMed Central
Google Scholar
Jensen RK, Leboeuf-Yde C. Is the presence of Modic changes associated with the outcomes of different treatments? A systematic critical review. BMC Musculoskelet Disord BioMed Central. 2011;12:183.
Google Scholar
Jensen OK, Nielsen CV, Sørensen JS, Stengaard-Pedersen K. Type 1 Modic changes was a significant risk factor for 1-year outcome in sick-listed low back pain patients: a nested cohort study using magnetic resonance imaging of the lumbar spine. Spine J. 2014;14(11):2568–81.
PubMed
Google Scholar
Lurie JD, Moses RA, Tosteson ANA, Tosteson TD, Carragee EJ, Carrino JA, et al. Magnetic resonance imaging predictors of surgical outcome in patients with lumbar intervertebral disc herniation. Spine (Phila Pa 1976). 2013;38(14):1216–25.
PubMed Central
Google Scholar
Fischgrund JS, Rhyne A, Franke J, Sasso R, Kitchel S, Bae H, et al. Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study. Eur Spine J. 2018;27(5):1146–56.
PubMed
Google Scholar
Fischgrund JS, Rhyne A, Franke J, Sasso R, Kitchel S, Bae H, et al. Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 2-year results from a prospective randomized double-blind sham-controlled multicenter study. Int J Spine Surg. 2019;13(2):110–9.
PubMed
PubMed Central
Google Scholar
Khalil JG, Smuck M, Koreckij T, Keel J, Beall D, Goodman B, et al. A prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain. Spine J. 2019;19(10):1620–32.
PubMed
Google Scholar
Lorio M, Clerk-Lamalice O, Beall DP, Julien T. International Society for the Advancement of Spine Surgery Guideline—intraosseous ablation of the basivertebral nerve for the relief of chronic low back pain. Int J Spine Surg. 2020;14(1):18–25.
PubMed
PubMed Central
Google Scholar
Shmagel A, Foley R, Ibrahim H. Epidemiology of chronic low back pain in US Adults: data from the 2009–2010 National Health and Nutrition Examination Survey. Arthritis Care Res (Hoboken). 2016;68(11):1688–94.
Google Scholar
Freburger JK, Holmes GM, Agans RP, Jackman AM, Darter JD, Wallace AS, et al. The rising prevalence of chronic low back pain. Arch Intern Med. 2009;169(3):251–8.
PubMed
PubMed Central
Google Scholar
Hartvigsen J, Hancock MJ, Kongsted A, Louw Q, Ferreira ML, Genevay S, et al. What low back pain is and why we need to pay attention. Lancet. 2018;391:2356–67.
PubMed
Google Scholar
Wang Y, Videman T, Battié MC. Modic changes: prevalence, distribution patterns, and association with age in white men. Spine J. 2012;12(5):411–6.
CAS
PubMed
PubMed Central
Google Scholar
Zhang YH, Zhao CQ, Jiang LS, Chen XD, Dai LY. Modic changes: a systematic review of the literature. Eur Spine J. 2008;17:1289–99.
PubMed
PubMed Central
Google Scholar
Mok FPS, Samartzis D, Karppinen J, Fong DYT, Luk KDK, Cheung KMC. Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort. Spine J. 2016;16(1):32–41.
PubMed
Google Scholar
Han C, Kuang MJ, Ma JX, Ma XL. Prevalence of Modic changes in the lumbar vertebrae and their associations with workload, smoking and weight in northern China. Sci Rep. 2017;7:46341.
CAS
PubMed
PubMed Central
Google Scholar
Urits I, Burshtein A, Sharma M, Testa L, Gold PA, Orhurhu V, et al. Low back pain, a comprehensive review: pathophysiology, diagnosis, and treatment. Curr Pain Headache Rep. 2019;23(3):23.
PubMed
Google Scholar
Kleinstück F, Dvorak J, Mannion AF. Are “structural abnormalities” on magnetic resonance imaging a contraindication to the successful conservative treatment of chronic nonspecific low back pain? Spine (Phila Pa 1976). 2006;31(19):2250–7.
Google Scholar
Buttermann GR. The effect of spinal steroid injections for degenerative disc disease. Spine J. 2004;4(5):495–505.
PubMed
Google Scholar
Fayad F, Lefevre-Colau M-M, Rannou F, Quintero N, Nys A, Macé Y, et al. Relation of inflammatory Modic changes to intradiscal steroid injection outcome in chronic low back pain. Eur spine J. 2007;16(7):925–31.
PubMed
PubMed Central
Google Scholar
Antonacci MD, Mody DR, Heggeness MH. Innervation of the human vertebral body: a histologic study. J Spinal Disord. 1998;11(6):526–31.
CAS
PubMed
Google Scholar
Torkki M, Majuri M-L, Wolff H, Koskelainen T, Haapea M, Niinimäki J, et al. Osteoclast activators are elevated in intervertebral disks with Modic changes among patients operated for herniated nucleus pulposus. Eur spine J. 2016;25(1):207–16.
PubMed
Google Scholar
Klawitter M, Hakozaki M, Kobayashi H, Krupkova O, Quero L, Ospelt C, et al. Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells. Eur spine J. 2014;23(9):1878–91.
PubMed
Google Scholar
Wuertz K, Vo N, Kletsas D, Boos N. Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-κB and MAP kinases. Eur Cell Mater. 2012;23:103–20.
CAS
PubMed
Google Scholar
Piccinini AM, Midwood KS. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm. 2010;2010:1–21.
Google Scholar
Mills KHG. TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol. 2011;11(12):807–22.
CAS
PubMed
Google Scholar
Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, et al. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? J Magn Reson Imaging. 2012;35(1):117–24.
PubMed
Google Scholar
Karchevsky M, Schweitzer ME, Carrino JA, Zoga A, Montgomery D, Parker L. Reactive endplate marrow changes: a systematic morphologic and epidemiologic evaluation. Skeletal Radiol. 2005;34(3):125–9.
PubMed
Google Scholar
Thomas GPL, Hemmrich K, Abberton KM, McCombe D, Penington AJ, Thompson EW, et al. Zymosan-induced inflammation stimulates neo-adipogenesis. Int J Obes (Lond). 2008;32(2):239–48.
CAS
Google Scholar
Monden M, Koyama H, Otsuka Y, Morioka T, Mori K, Shoji T, et al. Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of Toll-like receptor 2. Diabetes. 2013;62(2):478–89.
CAS
PubMed
PubMed Central
Google Scholar
Lim YZ, Wang Y, Wluka AE, Davies-Tuck ML, Hanna F, Urquhart DM, et al. Association of obesity and systemic factors with bone marrow lesions at the knee: a systematic review. Semin Arthritis Rheum. 2014;43(5):600–12.
PubMed
Google Scholar
Zhao Q, Cheng L, Yan H, Deng S, Zhao J, Liu Z, et al. The anatomical study and clinical significance of the sinuvertebral nerves at the lumbar levels. Spine (Phila Pa 1976). 2020;45(2):61–6.
Google Scholar
Shayota B, Wong TL, Fru D, David G, Iwanaga J, Loukas M, et al. A comprehensive review of the sinuvertebral nerve with clinical applications [Internet]. Anatomy Cell Biol. Korean. 2019; 52:128–33. pmc/articles/PMC6624329/?report=abstract. Accessed 29 Sep 2020
Degmetich S, Bailey JF, Liebenberg E, Lotz JC. Neural innervation patterns in the sacral vertebral body. Eur Spine J. 2016;25(6):1932–8.
PubMed
Google Scholar
Zehra U, Cheung JPY, Bow C, Crawford RJ, Luk KDK, Lu W, et al. Spinopelvic alignment predicts disc calcification, displacement, and Modic changes: Evidence of an evolutionary etiology for clinically-relevant spinal phenotypes. JOR Spine. 2020;3(1):e1083.
PubMed
PubMed Central
Google Scholar
Brown MF, Hukkanen MV, McCarthy ID, Redfern DR, Batten JJ, Crock HV, et al. Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. J Bone Jt Surg Br. 1997;79(1):147–53.
CAS
Google Scholar
Ware J, Kosinski M, Keller S. SF-36 Physical and mental health summary scales: a user’s manual. A user’s Man. 1994.
Becker S, Hadjipavlou A, Heggeness MH. Ablation of the basivertebral nerve for treatment of back pain: a clinical study. Spine J. 2017;17(2):218–23.
PubMed
Google Scholar
Herdman M, Gudex C, Lloyd A, Janssen M, Kind P, Parkin D, et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res. 2011;20:1727–36.
CAS
PubMed
PubMed Central
Google Scholar
Truumees E, Macadaeg K, Pena E, Arbuckle J, Gentile J, Funk R, et al. A prospective, open-label, single-arm, multi-center study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain. Eur Spine J. 2019;28(7):1594–602.
PubMed
Google Scholar
Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166(1 Pt 1):193–9.
CAS
PubMed
Google Scholar
Fairbank J, Couper J, Davies J, O’Brien J. The Oswestry low back pain disability questionnaire. Physiotherapy. 1980;66(8):271–3.
CAS
PubMed
Google Scholar
Freyd M. The graphic rating scale. J Educ Psychol. 1923;14(2):83–102.
Google Scholar
Fischgrund JS, Franke ARJ, Kitchel RSS, Yeung HBC. Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double—blind sham—controlled multi—center study. Eur Spine J. 2018;27(5):1146–56.
PubMed
Google Scholar
Fischgrund JS. Answer to the letter to the editor of Y. Li et al. concerning “ Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham—controlled multi-center study ” by Fischgrund JS, et al. [Eur Spine J; (2018) 27(5): 1146–1156]. Eur Spine J. 2019;28(9):2224.
PubMed
Google Scholar
Scott JW. Scott’s parabola. BMJ. 2001;323(7327):1477.
Google Scholar
Wong DA. Basivertebral nerve ablation: does the path followed suggest this technology is ready for adoption into clinical practice?: COMMENTARY ON: Khalil J et al. A prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the tr. Spine J. 2020;20:154–5.
PubMed
Google Scholar
Deyo RA, Smith DHM, Johnson ES, Donovan M, Tillotson CJ, Yang X, et al. Opioids for back pain patients: primary care prescribing patterns and use of services. J Am Board Fam Med. 2011;24(6):717–27.
PubMed
Google Scholar
Markman JD, Rhyne AL, Sasso RC, Patel AA, Hsu WK, Fischgrund JS, et al. Association between opioid use and patient-reported outcomes in a randomized trial evaluating basivertebral nerve ablation for the relief of chronic low back pain. Clin Neurosurg. 2020;86:343–7.
Google Scholar
Macnab I. Negative Disc Exploration. An analysis of the causes of nerve-root involvement in sixty-eight patients. J Bone Joint Surg Am. 1971;53(5):891–903.
CAS
PubMed
Google Scholar
Kim HS, Adsul N, Yudoyono F, Paudel B, Kim KJ, Choi SH, et al. Transforaminal epiduroscopic basivertebral nerve laser ablation for chronic low back pain associated with Modic changes: a preliminary open-label study. Pain Res Manag. 2018;2018:6857983
PubMed
PubMed Central
Google Scholar
Kim HS, Wu PH, Jang IT. Lumbar degenerative disease part 1: anatomy and pathophysiology of intervertebral discogenic pain and radiofrequency ablation of basivertebral and sinuvertebral nerve treatment for chronic discogenic back pain: a prospective case series and review of literature. Int J Mol Sci. 2020;21(4):1483.
CAS
PubMed Central
Google Scholar
Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine (Phila Pa 1976). 2006;31(18):2151–61.
Google Scholar
Ito K, Creemers L. Mechanisms of intervertebral disk degeneration/injury and pain: a review. Glob Spine J. 2013;3(3):145–52.
Google Scholar
Wu PH, Kim HS, Jang IT. Intervertebral disc diseases PART 2: a review of the current diagnostic and treatment strategies for intervertebral disc disease. Int J Mol Sci. 2020;22:2136.
Google Scholar