Kumar RN, Chambers WA, Pertwee RG. Pharmacological actions and therapeutic uses of cannabis and cannabinoids. Anaesthesia. 2001;56:1059–68.
CAS
PubMed
Article
Google Scholar
Hillig KW, Mahlberg PG. A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae). Am J Bot. 2004;91:966–75.
CAS
PubMed
Article
Google Scholar
Pertwee RG. Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities. Philos Trans R Soc B Biol Sci. 2012;367:3353–63.
CAS
Article
Google Scholar
Perucca E. Cannabinoids in the treatment of epilepsy: hard evidence at last? J Epilepsy Res. 2017;7:61–76.
PubMed
PubMed Central
Article
Google Scholar
Klauke AL, Racz I, Pradier B, et al. The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol. 2014;24:608–20.
CAS
PubMed
Article
Google Scholar
Zhang H, Lund DM, Ciccone HA, et al. Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain. Pain. 2018;159:1.
Article
Google Scholar
Malan TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F. CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? Curr Opin Pharmacol. 2003;3:62–7.
CAS
PubMed
Article
Google Scholar
Huestis MA. NIH public access. Chem Biodivers. 2009;4:1770–804.
Article
Google Scholar
Bajic D, Monory K, Conrad A, et al. Cannabinoid receptor type 1 in the brain regulates the affective component of visceral pain in mice. Neuroscience. 2018;384:397–405.
CAS
PubMed
Article
Google Scholar
Mouhamed Y, Vishnyakov A, Qorri B, et al. Therapeutic potential of medicinal marijuana: an educational primer for health care professionals. Drug Healthc Patient Saf. 2018;10:45–66.
PubMed
PubMed Central
Article
Google Scholar
Vermersch P, Trojano M. Tetrahydrocannabinol: cannabidiol oromucosal spray for multiple sclerosis-related resistant spasticity in daily practice. Eur Neurol. 2016;76:216–26.
CAS
PubMed
Article
Google Scholar
Medicines and Healthcare Products Regulatory Agency (MHRA). Sativex oromucosal spray. Public Assess Rep. 2010;1:1–129.
Google Scholar
Hayakawa K, Mishima K, Hazekawa M, et al. Cannabidiol potentiates pharmacological effects of Δ9-tetrahydrocannabinol via CB1 receptor-dependent mechanism. Brain Res. 2008;1188:157–64.
CAS
PubMed
Article
Google Scholar
Russo E, Guy GW. A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Med Hypotheses. 2005;66:234–46.
PubMed
Article
Google Scholar
Todd SM, Arnold JC. Neural correlates of interactions between cannabidiol and Δ9-tetrahydrocannabinol in mice: implications for medical cannabis. Br J Pharmacol. 2016;173:53–65.
CAS
PubMed
Article
Google Scholar
Rice J, Cameron M. Cannabinoids for treatment of MS symptoms: state of the evidence. Curr Neurol Neurosci Rep. 2018;18:50.
PubMed
Article
Google Scholar
Nielsen S, Germanos R, Weier M, et al. The use of cannabis and cannabinoids in treating symptoms of multiple sclerosis: a systematic review of reviews. Curr Neurol Neurosci Rep. 2018;18:8.
PubMed
Article
Google Scholar
Yadav V, Bever C, Bowen J, et al. Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014;82:1083–92.
PubMed
PubMed Central
Article
Google Scholar
Marinelli L, Balestrino M, Mori L, et al. A randomised controlled cross-over double-blind pilot study protocol on THC:CBD oromucosal spray efficacy as an add-on therapy for post-stroke spasticity. BMJ Open. 2017;7:1–6.
Article
Google Scholar
Ferrè L, Nuara A, Pavan G, et al. Efficacy and safety of nabiximols (Sativex®) on multiple sclerosis spasticity in a real-life Italian monocentric study. Neurol Sci. 2016;37:235–42.
PubMed
Article
Google Scholar
Langford RM, Mares J, Novotna A, et al. A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. J Neurol. 2013;260:984–97.
CAS
PubMed
Article
Google Scholar
Mercadante S, Portenoy RK. Breakthrough cancer pain. Pain. 2016;157:2657–63.
CAS
PubMed
Article
Google Scholar
Smith FL, Cichewicz D, Martin ZL, Welch SP. The enhancement of morphine antinociception in mice by Δ9-tetrahydrocannabinol. Pharmacol Biochem Behav. 1998;60:559–66.
CAS
PubMed
Article
Google Scholar
Lichtman AH, Lux EA, McQuade R, et al. Results of a double-blind, randomized, placebo-controlled study of nabiximols oromucosal spray as a adjunctive therapy in advanced cancer patients with chronic uncontrolled pain. J Pain Symptom Manage. 2017;55(2):179–188.e1.
PubMed
Article
Google Scholar
Fallon MT, Albert Lux E, McQuade R, et al. Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies. Br J Pain. 2017;11:119–33.
PubMed
PubMed Central
Article
Google Scholar
Portenoy RK, Ganae-Motan ED, Allende S, et al. Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. J Pain. 2012;13:438–49.
CAS
PubMed
Article
Google Scholar
Johnson JR, Lossignol D, Burnell-Nugent M, Fallon MT. An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics. J Pain Symptom Manag. 2013;46:207–18.
Article
Google Scholar
Serafimovska T, Arsova-Sarafinovska Z, Stefanoski S, et al. Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases. J Pain Res. 2018;11:837–42.
PubMed
PubMed Central
Article
Google Scholar
Nurmikko TJ, Serpell MG, Hoggart B, Toomey PJ, Morlion BJ, Haines D. Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial. Pain. 2007;133:210–20.
CAS
PubMed
Article
Google Scholar
Canadian Agency for Drugs and Technologies in Health (CADTH). Cannabinoid buccal spray for chronic non-cancer or neuropathic pain: a review of clinical effectiveness, safety, and guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health. 2016. https://www.ncbi.nlm.nih.gov/pubmed/27831665.
Blake DR, Robson P, Ho M, Jubb RW, McCabe CS. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology (Oxford). 2006;45:50–2.
CAS
Article
Google Scholar
Lynch ME, Cesar-Rittenberg P, Hohmann AG. A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. J Pain Symptom Manag. 2014;47:166–73.
Article
Google Scholar
Blake A, Wan BA, Malek L, et al. A selective review of medical cannabis in cancer pain management. Ann Palliat Med. 2017;6:215–22.
Article
Google Scholar
Russo M, Naro A, Leo A, et al. Evaluating Sativex® in neuropathic pain management: a clinical and neurophysiological assessment in multiple sclerosis. Pain Med (United States). 2016;17:1145–54.
Google Scholar
Serpell MG, Notcutt W, Collin C. Sativex long-term use: an open-label trial in patients with spasticity due to multiple sclerosis. J Neurol. 2013;260:285–95.
PubMed
Article
Google Scholar
Corroon J, Phillips JA. A cross-sectional study of cannabidiol users. Cannabis Cannabinoid Res. 2018;3:152–61.
CAS
PubMed
PubMed Central
Article
Google Scholar
Greenwich Biosciences, Inc. EPIDIOLEX® (cannabidiol) oral solution. Highlights of prescribing information. 2018. Carlsbad: Greenwich Biosciences, Inc. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210365lbl.pdf.
Babalonis S, Haney M, Malcolm RJ, et al. Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers. Drug Alcohol Depend. 2017;172:9–13.
CAS
PubMed
Article
Google Scholar
Welty TE, Luebke A, Gidal BE. Cannabidiol: promise and pitfalls. Epilepsy Curr. 2014;14:250–2.
PubMed
PubMed Central
Article
Google Scholar
Ward SJ, McAllister SD, Kawamura R, Murase R, Neelakantan H, Walker EA. Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT 1A receptors without diminishing nervous system function or chemotherapy efficacy. Br J Pharmacol. 2014;171:636–45.
CAS
PubMed
PubMed Central
Article
Google Scholar
Rodríguez-Muñoz M, Onetti Y, Cortés-Montero E, Garzón J, Sánchez-Blázquez P. Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 2018;11:1–12.
Article
Google Scholar
Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2016;20:936–48.
CAS
PubMed
Article
Google Scholar
Philpott HT, O’Brien M, McDougall JJ. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017;158:2442–51.
CAS
PubMed
PubMed Central
Article
Google Scholar
Moilanen LJ, Hämäläinen M, Nummenmaa E, et al. Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice—potential role of TRPA1 in osteoarthritis. Osteoarthr Cartil. 2015;23:2017–26.
CAS
PubMed
Article
Google Scholar
Li H, Kong W, Chambers CR, et al. The non-psychoactive phytocannabinoid cannabidiol (CBD) attenuates pro-inflammatory mediators, T cell infiltration, and thermal sensitivity following spinal cord injury in mice. Cell Immunol. 2018;329:1–9.
CAS
PubMed
PubMed Central
Article
Google Scholar
Azofeifa A, Mattson ME, Schauer G, McAfee T, Grant A, Lyerla R. National estimates of marijuana use and related indicators—National Survey on Drug Use and Health, United States, 2002–2014. MMWR Surveill Summ. 2016;65:1–28.
PubMed
Article
Google Scholar
Hasin DS. US epidemiology of cannabis use and associated problems. Neuropsychopharmacology. 2017;43:195–212.
PubMed
PubMed Central
Article
Google Scholar
Zhang M, Dong L, Zou H, et al. Effects of cannabinoid type 2 receptor agonist AM1241 on morphine-induced antinociception, acute and chronic tolerance, and dependence in mice. J Pain. 2018;19(10):1113–29
CAS
PubMed
Article
Google Scholar
DiNitto DM, Choi NG. Marijuana use among older adults in the USA: user characteristics, patterns of use, and implications for intervention. Int Psychogeriatr. 2011;23:732–41.
PubMed
Article
Google Scholar
Friedman D, Devinsky O. Cannabinoids in the treatment of epilepsy. N Engl J Med. 2015;373:1048–58.
CAS
PubMed
Article
Google Scholar
Thiele EA, Marsh ED, French JA, Mazurkiewicz-Beldzinska M, Benbadis SR, Joshi C, et al. Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2018;391(10125):1085–96.
CAS
PubMed
Article
Google Scholar
Kloft L. Review: The efficacy of cannabidiol (CBD) as potential antipsychotic medication. Maastricht Student J Psychol Neurosci. 2017;6:1–15.
Google Scholar