Abstract
The elemental composition of cholesterol stone has been determined by the DC arc optical emission spectroscopy. Qualitative analysis of gallstone reveals the presence of various elements such as Na, Ca, Mg, Cu, Fe, Si, Ni, Al, V, Tl, Sb, H, Li, and K with varying concentration. Apart from Ca being the dominant element, other elements like Na, K, Cu, Mg, and Si are seen to be present in significant proportions. Attempts are being made to systematically investigate the distribution of metallic elements in gallstone and correlate them with the disease conditions.
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References
Misciagna G, Centoze S, Leoci C, Guerra V, Cisternion AM, Ceo R, Trevisan M (1999) Diet, physical activity and gallstones-a population-based, case-control study in southern Italy. Am J Clin Nutr 69:121–126
Agarwal R, Singh VR (2000) Ultrasonic parameters and relationship between compressive strength, microstructure of gall bladder stones. Eur J Ultrasound 11:143–146
Marafi M, Makdisi Y, Bhatia KS, Abdullah AH, Kokaj Y, Mathew K, Quinn F, Qabazard A (1999) Laser ablation of gall bladder stones. Spectrochim Acta A 55:1291–1296
Rautray TR, Vijayan V, Panigrahi S (2007) Analysis of Indian pigment gallstones. Nucl Instrum Meth Phys Res B 225:409–415
Sutor DJ, Wooley SE (1971) A statistical survey of the composition of gallstones in eight countries. Gut 12:55–64
Whiting MJ, Watts JM (1985) Cholesterol gallstone pathogenesis: a study of potential nucleating agents for cholesterol crystal formation in bile. Clin Sci 68:589–596
Donovan JM (1999) Physical and metabolic factors in gallstone patogenesis. Gastroenterol Clin N Am 28:75–97
Ko CW, Lee SP (1999) Gallstone formation: local factors. Gastroenterol Clin N Am 28:99
Kaur T, Kaur S (2010) Pathophysiological conditions in cholelithiasis formation in north Indian population: spectroscopic, biophysical and biochemical study. Biol Trace Elem Res 138:79–89
Al-Kinani AT, Harris IA, Watt DE (1984) Analysis of minor and trace elements in gallstones by induction of characteristic ionizing radiation. Phys Med Biol 29:175–184
Pougnet MAB, Peisach M (1988) The application of a combined PIXE and XRD approach to the analysis of human stones. Nuclear instruments and methods in physics research. B 35:472–477
Kinci N, Sahin Y (2002) Determination of calcium and iodine in gallbladder stone using energy dispersive X-ray fluorescence spectrometry. Spectrochimica Acta B 57:167–171
Omer LS (2011) Quantitative analysis in (33) traces metal in human gallstone by ICP-AES. Int J Chem 3:105–110
Singh VK, Vinita Rai, Rai AK (2009) Variational study of the constituents of cholesterol stones by laser-induced breakdown spectroscopy. Lasers Med Sci 24:27–33
Pathak AP, Singh VK, Rai NK, Rai PK, Rai PK, Rai S, Baruah GD (2011) Study of different concentric rings inside gallstones with LIBS. Lasers Med Sci 26:531–537
Watmough SA, Hutchinson TC, Evans RD (1998) Development of solid calibration standards for trace elemental analyses of tree rings by laser ablation inductively coupled plasma mass spectrometry. Environ Sci Technol 32:2185–2190
Yamamoto H, Sakae T, Schafer H (1985) Analysis of vaterite microspherolith deposits on a pure cholesterol gallstone by X-ray diffraction, X-ray microanalysis and infrared absorption techniques. Virchows Arch A Pathol Anat Histopathol 405:463–471
Moroz TN, Palchik NA, Dar’in AV (2009) Microelemental and mineral compositions of pathogenic biomineral concrements: SRXFA, X-ray power diffraction and vibrational spectroscopy data. Nucl Instrum Methods Phys Res A 603:141–143
Banchob Sripa, Pipatphong Kanla, Poonsiri Sinawat, Haswell Elkins MR (2004) Opisthorchiasis-associated billiary stones: light and scanning electon microscopic study. World J Gastroenterol 10:3318–3321
Kaloustian J, de La Porte PL, El-Moselhy T, Lafont H, Portugal H (2005) Thermal analysis and characterization of cholesterol in gallstones. J Therm Anal Calorim 82:331–338
Suo T, Peng P, Feng M, Liu H, Al Z, Tong S, Yang X, Qin X (2012) Fixed-point and stratified analysis of the fine structure and composition of five gallstones with Fourier transform infrared (FT-IR) specular reflection spectroscopy. Microsc Res Tech 75:294–299
Liu G, Xing D, Yang H, Wu J (2002) Vibrational spectroscopic study of human pigment gallstones and their insoluble materials. J Mol Struct 616:187–191
Paluszkiewicz C, Kwiatek WM, Galka M, Sobheraj D, Wentrup-Byrne E (1998) FT-Raman, FT-IR spectroscopy and PIXE analysis applied to gallstones specimens. Cell Mol Biol 44:65–73
NIST, National Institute of Standards and Technology for the United States of America. http://www.physics.nist.gov/PhysRefData/ASD/linesform.html. Accessed 15 May 2012
Pearse RWB, Gaydon AG (1976) The Identification of molecular spectra, 4th edn. Wiley, New York
Acknowledgments
The authors are grateful to Prof. M.M. Joshi, Former Head, Department of Physics for his keen interest in the problem and fruitful discussion. They are also thankful to Mr. B.K. Singh, Photography Section of the Physics Department for providing Nickon SLR system.
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Srivastava, S., Tandon, P., Singh, R. et al. Elemental Composition of Gallstone by DC Arc Optical Emission Spectroscopy. Natl. Acad. Sci. Lett. 36, 397–402 (2013). https://doi.org/10.1007/s40009-013-0153-z
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DOI: https://doi.org/10.1007/s40009-013-0153-z