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Evaluation of antimicrobial effect of DA-5502 in gingivitis and periodontal diseases

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Abstract

The aim of present study was to examine the bactericidal and antimicrobial activity of novel DA-5502 in gingivitis and periodontal diseases. The in vitro antimicrobial activity of DA-5502 was investigated against two strains Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans by biofilm and planktonic method. DA-5502 effectively inhibited both the biofilm formation and oral bacteria in planktonic state for both P. gingivalis and A. actinomycetemcomitans strains, which results in reduction of plaque and gum inflammation. The in vitro results provide scientific evidence that our novel DA-5502 liquid dentifrice formulation composed of cetylpyridinium chloride, dipotassium glycyrrhizinate, and panthenol as main active pharmaceutical ingredients, has effective adsorption capacity with excellent antimicrobial, antigingivitis, and antiplaque activity to treat periodontal diseases.

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Acknowledgements

This article does not contain any studies with human and animal subjects performed by any of the authors.

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Authors and Affiliations

  1. College of Pharmacy, Yeungnam University, 214-1, Dae-dong, Gyeongsan, 712-749, South Korea

    Hima Bindu Ruttala, Chul Soon Yong & Jong Oh Kim

  2. Dong-A ST Research Institute, Pharmaceutical Product Research Laboratories, Yongin, 449-905, South Korea

    Min Kyung Kang, Hyoung Geun Park & Joon-Ho Jun

Authors
  1. Hima Bindu Ruttala
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  2. Min Kyung Kang
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  3. Hyoung Geun Park
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  4. Chul Soon Yong
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  5. Joon-Ho Jun
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  6. Jong Oh Kim
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Correspondence to Jong Oh Kim.

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Conflict of interest

Kang MK, HG Park, and Jun JH are the employees of Dong-A ST Research Institute; all remaining authors have no conflict of interest.

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Ruttala, H.B., Kang, M.K., Park, H.G. et al. Evaluation of antimicrobial effect of DA-5502 in gingivitis and periodontal diseases. J. Pharm. Investig. 48, 443–450 (2018). https://doi.org/10.1007/s40005-017-0328-6

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  • DOI: https://doi.org/10.1007/s40005-017-0328-6

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