Skip to main content
SpringerLink
Log in

Abies koreana Essential Oil Inhibits Drug-Resistant Skin Pathogen Growth and LPS-Induced Inflammatory Effects of Murine Macrophage

  • Communication
  • Published:
Lipids

Abstract

Since acne vulgaris is the combined result of a bacterial infection and the inflammatory response to that infection, we examined whether Abies koreana essential oil (AKE) possessed anti-inflammatory and antibacterial activities against skin pathogens. In this study, AKE showed excellent antibacterial activities against drug-susceptible and -resistant Propionibacterium acnes and Staphylococcus epidermidis, which are acne-causing bacteria. In addition, AKE reduced the LPS-induced secretion of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, NO and PGE2 in RAW 264.7 cells, indicating that it has anti-inflammatory effects. Therefore, we suggest that AKE may be an attractive candidate for promoting skin health.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Dreier J, Amantea E, Kellenberger L, Page MG (2007) Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. Antimicrob Agents Chemother 51:4361–4365

    Article  PubMed  Google Scholar 

  2. Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W (2005) Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. J Ethnopharmacol 101:330–333

    Article  PubMed  Google Scholar 

  3. Heller S, Kellenberger L, Shapiro S (2007) Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. Antimicrob Agents Chemother 51:1956–1961

    Article  PubMed  CAS  Google Scholar 

  4. Ross JI, Snelling AM, Carnegie E, Coates P, Cunliffe WJ, Bettoli V, Tosti G, Katsambas A, Galvan Peréz Del Pulgar JI, Rollman O, Török L, Eady EA, Cove JH (2003) Antibiotic-resistant acne: lessons from Europe. Br J Dermatol 148:467–478

    Article  PubMed  CAS  Google Scholar 

  5. Eady EA, Gloor M, Leyden JJ (2003) Propionibacterium acnes resistance: a world-wide problem. Dermatology 206:54–56

    Article  PubMed  CAS  Google Scholar 

  6. Swanson JK (2003) Antibiotic resistance of Propionibacterium acnes in acne vulgaris. Dermatol Nurs 15:359–362

    PubMed  Google Scholar 

  7. Zesch A (1988) Adverse reactions of externally applied drugs and inert substances. Derm Beruf Umwelt 36:128–133

    PubMed  CAS  Google Scholar 

  8. Eady EA (1998) Bacterial resistance in acne. Dermatology 196:59–66

    Article  PubMed  CAS  Google Scholar 

  9. Wawruch M, Bozekova L, Krcmery S, Kriska M (2002) Risks of antibiotic treatment. Bratisl Lek Listy 103:270–275

    PubMed  CAS  Google Scholar 

  10. Park J, Lee J, Jung E, Park Y, Kim K, Park B, Jung K, Park E, Kim J, Park D (2004) In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. Eur J Pharmacol 496:189–195

    Article  PubMed  CAS  Google Scholar 

  11. Jain A, Basal E (2003) Inhibition of Propionibacterium acnes-induced mediators of inflammation by Indian herbs. Phytomedicine 10:34–38

    Article  PubMed  CAS  Google Scholar 

  12. Lim YH, Kim IH, Seo JJ (2007) In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes. J Microbiol 45:473–477

    PubMed  CAS  Google Scholar 

  13. Joo SS, Jang SK, Kim SG, Choi JS, Hwang KW, Lee DI (2008) Anti-acne activity of Selaginella involvens extract and its non-antibiotic antimicrobial potential on Propionibacterium acnes. Phytother Res 22:335–339

    Article  PubMed  Google Scholar 

  14. Kim SS, Kim JY, Lee NH, Hyun CG (2008) Antibacterial and anti-inflammatory effects of Jeju medicinal plants against acne-inducing bacteria. J Gen Appl Microbiol 54:101–106

    Article  PubMed  CAS  Google Scholar 

  15. Leyden J (2008) New developments in topical antimicrobial therapy for acne. J Drugs Dermatol 7:s8–11

    PubMed  Google Scholar 

  16. Marcinkiewicz J, Wojas-Pelc A, Walczewska M, Lipko-Godlewska S, Jachowicz R, Maciejewska A, Białecka A, Kasprowicz A (2008) Topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study. Eur J Dermatol 18:433–439

    PubMed  CAS  Google Scholar 

  17. Baik JS, Kim SS, Lee JA, Oh TH, Kim JY, Lee NH, Hyun CG (2008) Chemical composition and biological activities of essential oils extracted from Korean endemic citrus species. J Microbiol Biotechnol 18:74–79

    PubMed  Google Scholar 

  18. Kim HJ, Choi EH, Lee IS (2004) Two lanostane triterpenoids from Abies koreana. Phytochemistry 65:2545–2549

    Article  PubMed  CAS  Google Scholar 

  19. Kim HJ, Le QK, Lee MH, Kim TS, Lee HK, Kim YH, Bae K, Lee IS (2001) A cytotoxic secocycloartenoid from Abies koreana. Arch Pharm Res 24:527–531

    Article  PubMed  CAS  Google Scholar 

  20. Kim K, Bu Y, Jeong S, Lim J, Kwon Y, Cha DS, Kim J, Jeon S, Eun J, Jeon H (2006) Memory-enhancing effect of a supercritical carbon dioxide fluid extract of the needles of Abies koreana on scopolamine-induced amnesia in mice. Biosci Biotechnol Biochem 70:1821–1826

    Article  PubMed  CAS  Google Scholar 

  21. Jeong SI, Lim JP, Jeon H (2007) Chemical composition and antibacterial activities of the essential oil from Abies koreana. Phytother Res 21:1246–1250

    Article  PubMed  CAS  Google Scholar 

  22. Kim JY, Oh TH, Kim BJ, Kim SS, Lee NH, Hyun CG (2008) Chemical composition and anti-inflammatory effects of essential oil from Farfugium japonicum flower. J Oleo Sci 57:623–628

    PubMed  CAS  Google Scholar 

  23. Yoon WJ, Ham YM, Kim KN, Park SY, Lee NH, Hyun CG, Lee WJ (2009) Anti-inflammatory activity of brown alga Dictyota dichotoma in murine macrophage RAW 264.7 cells. J Med Plant Res 3:1–8

    Article  Google Scholar 

Download references

Acknowledgments

This research was supported by the Regional Technology Innovation Program (RTI04-02-07), which is managed by the Ministry of Knowledge and Economy, Korea.

Author information

Authors and Affiliations

  1. Research Group for Cosmetic Materials, Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju, 697-943, Korea

    Weon-Jong Yoon & Chang-Gu Hyun

  2. Department of Chemistry, Cheju National University, Jeju, 690-756, Korea

    Sang-Suk Kim, Tae-Heon Oh & Nam Ho Lee

Authors
  1. Weon-Jong Yoon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sang-Suk Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tae-Heon Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nam Ho Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chang-Gu Hyun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chang-Gu Hyun.

About this article

Cite this article

Yoon, WJ., Kim, SS., Oh, TH. et al. Abies koreana Essential Oil Inhibits Drug-Resistant Skin Pathogen Growth and LPS-Induced Inflammatory Effects of Murine Macrophage. Lipids 44, 471–476 (2009). https://doi.org/10.1007/s11745-009-3297-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11745-009-3297-3

Keywords

Search

Navigation