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In vitro characterization and pharmacodynamic evaluation of furosemide loaded self nano emulsifying drug delivery systems (SNEDDS)

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Abstract

Poor water solubility is one of the reasons for erratic absorption after oral administration of furosemide (FSM), an antihypertensive loop diuretic. Self nano emulsifying drug delivery system (SNEDDS) is a novel drug delivery system utilized to improve the water solubility, permeability and ultimately bioavailability. FSM solubility was determined in various vehicles oils, surfactants and co surfactants. Self emulsification region for the rational design of SNEDDS formulations were identified by pseudoternary diagrams. Developed formulations were characterized by zeta potential determination, droplet size analysis, dilution test, viscosity determination, in vitro dissolution studies and in vivo pharmacodynamic evaluation. A remarkable increase in dissolution was observed for the optimized SNEDDS when compared with the plain FSM and marketed formulation by in vitro dissolution studies. The pharmacological effect of FSM was improved by SNEDDS formulation as compared to plain FSM. The study confirmed that the SNEDDS formulation can be used as a possible alternative to traditional oral formulations of FSM to improve its bioavailability.

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Acknowledgments

All authors (P. Yadav, E. Yadav, A. Verma, S Amin) declare that they have no conflict of interest. Authors are extremely thankful to Gattefosse (France), Abitec Corporation (USA) and BASF Chemicals (USA) for providing gift samples of various oils, surfactants and co-surfactants. Authors are grateful to Dr. Vikas Kumar for his valuable suggestions and material support during research work.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS), Allahabad, 211 007, India

    Pankajkumar Yadav, Ekta Yadav & Amita Verma

  2. Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, 110 062, India

    Saima Amin

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  1. Pankajkumar Yadav
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  2. Ekta Yadav
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  3. Amita Verma
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  4. Saima Amin
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Correspondence to Pankajkumar Yadav.

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Yadav, P., Yadav, E., Verma, A. et al. In vitro characterization and pharmacodynamic evaluation of furosemide loaded self nano emulsifying drug delivery systems (SNEDDS). Journal of Pharmaceutical Investigation 44, 443–453 (2014). https://doi.org/10.1007/s40005-014-0138-z

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  • DOI: https://doi.org/10.1007/s40005-014-0138-z

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