![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs15036-023-3283-2/MediaObjects/15036_2023_3283_Fig1_HTML.jpg)
© Springer Medizin Verlag 2019
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs15036-023-3283-2/MediaObjects/15036_2023_3283_Fig2_HTML.jpg)
© mod. nach [5]
Literatur
Topalian SL et al. Safety, activity, and immune correlates of anti-PD-1 antibodyincancer. N Engl J Med. 2012;366:2443-54
Le DT et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372:2509-20
Le DT et al. Phase II open-label study of pembrolizumab in treatment-refractory, microsa- tellite instability-high/mismatch repair-deficient metastatic colorectal cancer: KEYNOTE-164. J Clin Oncol. 2020;38:11-9
Andre T et al. Nivolumab plus low-dose ipilimumab in previously trea- ted patients with microsatellite instability-high/ mismatch repair-deficient metastatic colorectal cancer: 4-yearfollow-upfrom CheckMate 142. Ann Oncol. 2022;33:1052-60
Andre T et al. Pembrolizumab in microsatel- lite-instability-high advanced colorectal cancer. N Engl J Med. 2020;383:2207-18
Lenz HJ et al. First-line Nivolu- mab plus low-dose Ipilimumab for microsatellite instability-high/mismatch repair-deficient meta- static colorectal cancer: the phase II checkmate 142 study. J Clin Oncol. 2022;40:161-70
Antoniotti C et al. Upfront FOLFOXIRI plus bevacizumab with or without atezolizumab in the treatment of patients with metastatic colorectal cancer (AtezoTRIBE): a multicentre, open-label, randomised, controlled, phase 2 trial. Lancet Oncol. 2022;23:876-87
Mettu NB et al. Assessment of capecitabine and bevacizumab with or without atezolizumab for the treatment of refractory metastatic colorectal cancer: arandomized clinical trial. JAMA Netw Open. 2022;5:e2149040
Cercek A et al. PD-1 blockade in mismatch repair-deficient, locally advanced rectal cancer. N Engl J Med. 2022;386:2363-76
Papke DJ Jr et al. Prevalence of mismatch-repair deficiency in rectal adenocarci- nomas. N Engl J Med. 2022;387:1714-16
Chalabi M et al. Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage coloncancers. Nat Med. 2020;26:566-76
Chalabi M et al. Neoadjuvant immune checkpoint inhibition in locally advanced MMR- deficient colon cancer: the NICIE-2 study. Ann Oncol. 2022;33(suppl_7):S808-69 (LBA7)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pox, C. Welchen Nutzen haben Immuntherapien beim kolorektalen Karzinom?. Gastro-News 10, 41–44 (2023). https://doi.org/10.1007/s15036-023-3283-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s15036-023-3283-2