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Antiretrovirale Therapie

Neues aus der Forschungspipeline

What can new substances offer?

  • FORTBILDUNG . ÜBERSICHT
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MMW - Fortschritte der Medizin Aims and scope

Immer wieder betonen HIV-Experten, dass die antiretrovirale Therapie ein Optimum an Wirkung und Verträglichkeit erreicht hat [1, 2]. Dennoch wird weiterhin an neuen Substanzen geforscht. Nachfolgend ein Überblick über die Entwicklung.

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Literatur

  1. Bogner J. [Everyday life with HIV: everything „normal“?]. MMW Fortschr Med 2016;158 Suppl 1:3.

    PubMed  Google Scholar 

  2. Bogner J. [We have tamed HIV—let’s stay doubly vigilant!]. MMW Fortschr Med 2014;156 Suppl 1:14.

    PubMed  Google Scholar 

  3. Kuritzkes DR, Jacobson J, Powderly WG, et al. Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1. J Infect Dis 2004;189:286–91.

    Article  CAS  PubMed  Google Scholar 

  4. ClinicalTrials: Ibalizumab Plus Optimized Background Regimen in Treatment-Experienced Patients With Multi-Drug Resistant HIV-1. 2016. (Accessed 27.12.2016, 2016, at https://www.clinicaltrials.gov/ct2/show/NCT02707861?term=Ibalizumab&rank=2.)

  5. Pipeline: TMB-355 (Ibalizumab). 2016. at http://www.taimedbiologics.com/en/info/TMB355.aspx.)

  6. Lalezari JP, Latiff GH, Brinson C, et al. Safety and efficacy of the HIV-1 attachment inhibitor prodrug BMS-663068 in treatment-experienced individuals: 24 week results of AI438011, a phase 2b, randomised controlled trial. Lancet HIV 2015;2:e427–37.

    Article  PubMed  Google Scholar 

  7. Lalezari J, Latiff GH, Brinson C, et al. Safety profile of HIV-1 attachment inhibitor prodrug BMS-663068 in antiretroviral-experienced subjects: week 24 analysis. J Int AIDS Soc 2014;17:19530.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Beatty G, Jacobson J, Lalezari J,. Abstract H-416D tI, Washington. Safety and Antiviral Activity of PA-457, the First-In-Class Maturation Inhibitor, in a 10-Day Monotherapy Study in HIV-1 Infected Patients. ICAAC. Washington2005.

  9. Nowicka-Sans B, Protack T, Lin Z, et al. Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage. Antimicrob Agents Chemother 2016;60:3956–69.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Regueiro-Ren A, Liu Z, Chen Y, et al. Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity. ACS Med Chem Lett 2016;7:568–72.

    Article  CAS  PubMed  Google Scholar 

  11. Hwang C, Schürmann D, Sobotha C. Antiviral Activity/Safety of a Second-Generation HIV-1 Maturation Inhibitor. CROI. Seattle, Washington2015:oral session.

  12. ViiV_Healthcare. Letter to investigators on the purchase Bristol-Myers Squibb’s HIV R&D pipeline in two deals. online communication

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Authors and Affiliations

  1. Sektion Klinische Infektiologie, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Campus Innenstadt, Pettenkoferstr. 8a, D-80336, München, Deutschland

    Johannes Bogner

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  1. Johannes Bogner
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Correspondence to Johannes Bogner.

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Bogner, J. Neues aus der Forschungspipeline. MMW - Fortschritte der Medizin 159 (Suppl 2), 34–36 (2017). https://doi.org/10.1007/s15006-017-9733-z

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  • DOI: https://doi.org/10.1007/s15006-017-9733-z

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