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Applications of Bacterial Cellulose-Based Composite Materials in Hard Tissue Regenerative Medicine

  • Review Article
  • Published:
Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Background:

Cartilage, bone, and teeth, as the three primary hard tissues in the human body, have a significant application value in maintaining physical and mental health. Since the development of bacterial cellulose-based composite materials with excellent biomechanical strength and good biocompatibility, bacterial cellulose-based composites have been widely studied in hard tissue regenerative medicine. This paper provides an overview of the advantages of bacterial cellulose-based for hard tissue regeneration and reviews the recent progress in the preparation and research of bacterial cellulose-based composites in maxillofacial cartilage, dentistry, and bone.

Method:

A systematic review was performed by searching the PubMed and Web of Science databases using selected keywords and Medical Subject Headings search terms.

Results:

Ideal hard tissue regenerative medicine materials should be biocompatible, biodegradable, non-toxic, easy to use, and not burdensome to the human body; In addition, they should have good plasticity and processability and can be prepared into materials of different shapes; In addition, it should have good biological activity, promoting cell proliferation and regeneration. Bacterial cellulose materials have corresponding advantages and disadvantages due to their inherent properties. However, after being combined with other materials (natural/ synthetic materials) to form composite materials, they basically meet the requirements of hard tissue regenerative medicine materials. We believe that it is worth being widely promoted in clinical applications in the future.

Conclusion:

Bacterial cellulose-based composites hold great promise for clinical applications in hard tissue engineering. However, there are still several challenges that need to be addressed. Further research is needed to incorporate multiple disciplines and advance biological tissue engineering techniques. By enhancing the adhesion of materials to osteoblasts, providing cell stress stimulation through materials, and introducing controlled release systems into matrix materials, the practical application of bacterial cellulose-based composites in clinical settings will become more feasible in the near future.

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Acknowledgements

This work is supported by Science and Technology Innovation Leader and Key Talent Team Project of Shanxi Province (202204051002034), Key Research and Development Plan of Shanxi Province (202102130501002), Scientific Research Project for Returned Overseas Professionals of Shanxi Province (2022-120), Key national science and technology cooperation project of Shanxi Provincial Department of Science and Technology (202204041101004) and the Shanxi Province Basic Research Program (free exploration) Project (20210302124085); Programs of Higher Education Institutions in Shanxi (2020L0212).

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  1. Yingyu Liu, Haiyan Liu and Susu Guo have contributed equally to this work.

Authors and Affiliations

  1. Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China

    Yingyu Liu, Haiyan Liu, Susu Guo, Jin Qi, Ran Zhang, Xiaoming Liu, Lingxiang Sun, Mingrui Zong, Huaiyi Cheng, Xiuping Wu & Bing Li

  2. Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, China

    Yingyu Liu, Haiyan Liu, Susu Guo, Jin Qi, Ran Zhang, Xiaoming Liu, Lingxiang Sun, Mingrui Zong, Huaiyi Cheng, Xiuping Wu & Bing Li

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  1. Yingyu Liu
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Contributions

YL designed the structure and content,assembled the literature and wrote this review. HL, SG, JQ, RZ, XL, HC, LS, MZ, XW and BL provided suggestions and revised this review.

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Correspondence to Xiuping Wu or Bing Li.

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Liu, Y., Liu, H., Guo, S. et al. Applications of Bacterial Cellulose-Based Composite Materials in Hard Tissue Regenerative Medicine. Tissue Eng Regen Med 20, 1017–1039 (2023). https://doi.org/10.1007/s13770-023-00575-4

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