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Surface-Modifying Effect of Zwitterionic Polyurethane Oligomers Complexed with Metal Ions on Blood Compatibility

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Background

To prevent unsolved problems of medical devices, we hypothesized that combinatorial effects of zwitterionic functional group and anti-bacterial metal ions can reduce effectively the thrombosis and bacterial infection of polymeric biomaterials. In this research, we designed a novel series of zwitterionic polyurethane (zPU) additives to impart anti-thrombotic properties to a polyvinyl chloride (PVC) matrix.

Methods

We have synthesized zPUs by combination of various components and zPUs complexed with metal ions. Zwitterion group was prepared by reaction with 1,3-propane sultone and Nmethyldiethanolamine and metal ions were incorporated into sulfobetaine chains via molecular complexation. These zPU additives were characterized using FT-IR, 1H-NMR, elemental analysis, and thermal analysis. The PVC film blended with zPU additives were prepared by utilizing a solvent casting and hot melting process.

Results

Water contact angle demonstrated that the introduction of zwitterion group has improved hydrophilicity of polyurethanes dramatically. Protein adsorption test resulted in improved anti-fouling effects dependent on additive concentration and decreases in their effects by metal complexation. Platelet adhesion test revealed anti-fouling effects by additive blending but not significant as compared to protein resistance results.

Conclusion

With further studies, the synthesized zPUs and zPUs complexed with metal ions are expected to be used as good biomaterials in biomedical fields. Based on our results, we can carefully estimate that the enhanced anti-fouling effect contributed to reduced platelet adhesion.

Graphic Abstract

Schematic explanation of the effect of zwitterionic polyurethane additives for blood-compatible and anti-bacterial bulk modification.

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Acknowledgements

This work was supported by the Next Generation Medical Device Platform Program (2015M3A9E2028580), the Basic Science Research Program (2020R1A2B5B0300234), and the Korea Medical Device Development Fund funded by the Korea Government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, and the Ministry of Food and Drug Safety, Republic of Korea) (202011B31 and 202011A05-05) through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT (MSIT), Republic of Korea.

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Author notes

  1. Dong-Heon Ga and Chung-Man Lim have contributed equally to this work.

Authors and Affiliations

  1. Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 02792, Republic of Korea

    Dong-Heon Ga, Chung-Man Lim, Yoonsun Jang & Yoon Ki Joung

  2. Department of Biotechnology and BET Research Institute, Chung-Ang University, 4726 Seodong-daero, Daedeok-myeon, Anseong-si, Gyeonggi-do, 17546, Republic of Korea

    Dong-Heon Ga & Tae Il Son

  3. Department of Biomedical Science, College of Life Sciences, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi, 13488, Republic of Korea

    Dong Keun Han

  4. Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 02792, Republic of Korea

    Yoon Ki Joung

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  1. Dong-Heon Ga
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Correspondence to Dong Keun Han or Yoon Ki Joung.

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Ga, DH., Lim, CM., Jang, Y. et al. Surface-Modifying Effect of Zwitterionic Polyurethane Oligomers Complexed with Metal Ions on Blood Compatibility. Tissue Eng Regen Med 19, 35–47 (2022). https://doi.org/10.1007/s13770-021-00400-w

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