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Comparison between total knee arthroplasty and MCIC (autologous bone marrow mesenchymal-cell-induced-chondrogenesis) for the treatment of osteoarthritis of the knee

  • Original Article
  • Regenerative Medicine
  • Published:
Tissue Engineering and Regenerative Medicine Aims and scope

An Erratum to this article was published on 10 November 2014

Abstract

Total knee arthroplasty (TKA) is the gold standard of treatment for advanced osteoarthritis of the knee. The technical methods of cartilage regeneration procedures are now well-developed. Indications for this procedure are being expanded to the treatment of osteoarthritis. We compared data from 42 patients who underwent TKA and from 52 patients who underwent MCIC (autologous bone marrow mesenchymal-cell-induced-chondrogenesis). All patients were over 50 years of age and showed grade IV of the Kellgren-Lawrence classification. The TKA patients were older and predominantly female, compared to the MCIC patients. There was no difference between the two groups regarding the patient satisfaction. Clinical evaluation of the two groups showed significant mean improvement in the tKSS-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. The monetary cost of TKA was relatively higher than that of MCIC. Therefore, considering the patient age and quality of life, MCIC is a potential treatment option for osteoarthritis as it thus delays the disease progression.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Catholic, Korea

    Seok Jung Kim, Nam Yong Choi & Joon Su Park

  2. Graduate School of Healthcare Management and Policy, The Catholic Institute for Health Management Research, The Catholic University of Korea, Catholic, Korea

    Jang Mook Kim

  3. Department of Nursing, Seojeong University of Korea, Seojeong, Korea

    Ju Rang Han

  4. Faculty of Health and Social Sciences, Canterbury Christ Church University, 30 Pembroke Court, Chatham Maritime, Kent, ME4 4UF, United Kingdom

    Asode Ananthram Shetty

Authors
  1. Jang Mook Kim
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  2. Ju Rang Han
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  3. Asode Ananthram Shetty
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  4. Seok Jung Kim
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Correspondence to Seok Jung Kim.

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Kim, J.M., Han, J.R., Shetty, A.A. et al. Comparison between total knee arthroplasty and MCIC (autologous bone marrow mesenchymal-cell-induced-chondrogenesis) for the treatment of osteoarthritis of the knee. Tissue Eng Regen Med 11, 405–413 (2014). https://doi.org/10.1007/s13770-014-0041-8

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  • DOI: https://doi.org/10.1007/s13770-014-0041-8

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