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The effect of age on clinical outcomes in critically ill brain-injured patients

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Abstract

Purpose

We studied the impact of age on survival and functional recovery in brain-injured patients.

Methods

We performed an observational cohort study of all consecutive adult patients with brain injury admitted to ICU in 8 years. To estimate the optimal cut-off point of the age associated with unfavorable outcomes (mRS 3–6), receiver operating characteristic (ROC) curve analyses were used. Multivariate logistic regression analyses were performed to identify prognostic factors for unfavorable outcomes.

Results

We included 619 brain-injured patients. We identified 60 years as the cut-off point at which the probability of unfavorable outcomes increases. Patients ≥ 60 years had higher severity scores at ICU admission, longer duration of mechanical ventilation, longer ICU and hospital stays, and higher mortality. Factors identified as associated with unfavorable outcomes (mRS 3–6) were an advanced age (≥ 60 years) [Odds ratio (OR) 4.59, 95% confidence interval (CI) 2.73–7.74, p < 0.001], a low GCS score (≤ 8 points) [OR 3.72, 95% CI 1.95–7.08, p < 0.001], the development of intracranial hypertension [OR 5.52, 95% CI 2.70–11.28, p < 0.001], and intracerebral hemorrhage as the cause of neurologic disease [OR 3.87, 95% CI 2.34–6.42, p < 0.001].

Conclusion

Mortality and unfavorable functional outcomes in critically ill brain-injured patients were associated with older age (≥ 60 years), higher clinical severity (determined by a lower GCS score at admission and the development of intracranial hypertension), and an intracerebral hemorrhage as the cause of neurologic disease.

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Funding

This study was funded by Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES).

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Authors and Affiliations

  1. Hospital Universitario de Getafe and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Intensive Care Unit, Carretera de Toledo, km 12.5, 28905, Getafe, Spain

    Eva E. Tejerina, Fernando Frutos-Vivar & José Ángel Lorente

  2. Hospital Universitario de Getafe, Madrid, Spain

    Gesly Gonçalves, Karen Gómez-Mediavilla, Carlos Jaramillo & Jorge Jiménez

  3. Universidad Europea de Madrid, Madrid, Spain

    Israel J. Thuissard & Cristina Andreu-Vázquez

Authors
  1. Eva E. Tejerina
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  2. Gesly Gonçalves
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  3. Karen Gómez-Mediavilla
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  4. Carlos Jaramillo
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  5. Jorge Jiménez
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  6. Fernando Frutos-Vivar
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  7. José Ángel Lorente
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  8. Israel J. Thuissard
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  9. Cristina Andreu-Vázquez
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Correspondence to Eva E. Tejerina.

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Tejerina, E.E., Gonçalves, G., Gómez-Mediavilla, K. et al. The effect of age on clinical outcomes in critically ill brain-injured patients. Acta Neurol Belg 123, 1709–1715 (2023). https://doi.org/10.1007/s13760-022-01987-0

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  • DOI: https://doi.org/10.1007/s13760-022-01987-0

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