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Design, synthesis and self-assembly of amide-linked dendron-based non-ionic amphiphiles

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Abstract

In this manuscript, we discussed the synthesis of non-ionic (C18) and (C18-cis) amphiphiles from [PG]-dendron-based biocompatible starting materials. The physicochemical studies of amphiphiles show some significant results. The presence of an amide as a linker group has affected the hydrophilicity of the amphiphiles to respond to a low critical micelle concentration. The graph of surface tension versus concentration shows that the CMC of non-ionic amphiphiles falls in the range of 18.10 µmol L−1–00.61 µmol L−1. The dynamic light scattering study of the synthesized compounds confirmed that the G.n-amide amphiphiles with the unsaturation 6, 8 and 10 have an average aggregated particle size range of 93.0 nm–13.0 nm, while the average aggregated particle size of saturated amphiphiles 13, 15 and 17 showed a range from 28.0 nm to 7.5 nm. The morphological study of self-aggregated particles of amphiphiles using transmission electron microscopy studies in an aqueous medium showed the worm-like shape for G.1 amphiphiles and circular shape for G.2 and G.3 amphiphiles.

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Authors and Affiliations

  1. University School of Basic and Applied Sciences, Guru Gobind Singh Indraprastha University, Dwarka, New Delhi, India

    Ashwani Kumar & Yogesh Kumar Tyagi

  2. Department of Applied Chemistry, Delhi Technological University, Rohini, New Delhi, India

    Ram Singh

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  1. Ashwani Kumar
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  2. Ram Singh
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Correspondence to Yogesh Kumar Tyagi.

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Kumar, A., Singh, R. & Tyagi, Y.K. Design, synthesis and self-assembly of amide-linked dendron-based non-ionic amphiphiles. J IRAN CHEM SOC 19, 1167–1177 (2022). https://doi.org/10.1007/s13738-021-02370-1

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