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One-pot synthesis of sulfonylhydrazones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water

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Abstract

A facile and eco-friendly protocol for the synthesis of sulfonylhydrazones from sulfonyl chlorides, hydrazine hydrate and vinyl azides was developed. The unique advantage of this approach is that desired products can be obtained efficiently in water, which meets the requirements of green chemistry and provides good perspectives for the sustainable production of new drug candidate. Also, this reaction proceeded in moderate to good yields with a wide tolerance of functional groups.

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Acknowledgements

We gratefully acknowledge the financial support from Zhejiang Provincial Natural Science foundation of China (No. LQ16H090004) and Research Project of Shaoxing University (No. 2017LG1003). We also thank Anna Kerkula for English language editing.

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  1. Mengqiang Luo and Hai Wang contributed equally to this work

Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, 312000, Zhejiang, People’s Republic of China

    Mengqiang Luo, Xiaorong Ren, Ruijuan Lu, Chenze Qi, Yaohong Zhang & Runpu Shen

  2. School of Life Science, Shaoxing University, Shaoxing, 312000, Zhejiang, People’s Republic of China

    Hai Wang

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  1. Mengqiang Luo
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Correspondence to Yaohong Zhang or Runpu Shen.

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Luo, M., Wang, H., Ren, X. et al. One-pot synthesis of sulfonylhydrazones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water. J IRAN CHEM SOC 18, 2713–2722 (2021). https://doi.org/10.1007/s13738-021-02226-8

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  • DOI: https://doi.org/10.1007/s13738-021-02226-8

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