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Synthesis of diverse pyrazole-4-sulfonyl chlorides starting from 2-(benzylthio)malonaldehyde

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Abstract

A series of pyrazole-4-sulfonyl chlorides was obtained by a convenient 2-step method starting from synthetically available 2-(benzylthio)malonaldehyde. The method can be applied for the effective multi-gram synthesis of diverse pyrazole-containing sulfonyl chlorides which are mostly not available by other methods.

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Acknowledgments

We express our appreciation to Dr. S. I. Vdovenko and O. A. Fedorenko (Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences, Ukraine) for measuring the IR-spectra.

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Authors and Affiliations

  1. Kyiv National Taras Shevchenko University, 64 Volodymirska st., Kyiv, 33, 01033, Ukraine

    Pavlo A. Sokolyuk, Olexiy V. Gavrylenko & Andrey A. Tolmachov

  2. Enamine Ltd., 23 A. Matrosova st., Kyiv, 01103, Ukraine

    Pavlo A. Sokolyuk, Ivan S. Kondratov, Olexiy V. Gavrylenko & Andrey A. Tolmachov

  3. Institute of Bioorganic Chemistry and Petrochemistry, National Ukrainian Academy of Science, Murmanska 1, Kyiv, 94, 02660, Ukraine

    Ivan S. Kondratov

Authors
  1. Pavlo A. Sokolyuk
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  2. Ivan S. Kondratov
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  3. Olexiy V. Gavrylenko
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  4. Andrey A. Tolmachov
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Corresponding author

Correspondence to Ivan S. Kondratov.

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Sokolyuk, P.A., Kondratov, I.S., Gavrylenko, O.V. et al. Synthesis of diverse pyrazole-4-sulfonyl chlorides starting from 2-(benzylthio)malonaldehyde. Mol Divers 20, 1–7 (2016). https://doi.org/10.1007/s11030-015-9633-z

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  • DOI: https://doi.org/10.1007/s11030-015-9633-z

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