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Molecular modeling and cyclization reactions of 2-(4-oxothiazolidine-2-ylidene) acetonitrile

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Abstract

Diazotization of 2-(4-oxothiazolidine-2-ylidene) acetonitrile 1 with aryl diazonium chloride derivatives afforded 4-thiazolidinones 2a, b, whereas 3a, b derivatives produced through reaction of arylcarbonohydrazonoyl dicyanide with thioglycolic acid. Cyclization of 2a with aromatic aldehydes and malononitrile gave the expected substituted thiazolo [3,2-a] pyridines 4a, b. The reaction of 1 with anthraldehyde (1:1 molar ratio) gave the expected 4,5-dihydro-4-oxothiazole derivatives 5 which condensed with other mole p-chlorobenzaldehyde and gave the corresponding bisarylidine derivative 6. Thiazolo [3,2-a] pyridine enaminonitrile derivative 7 produced through addition of malononitrile to bisarylidine 6. Also, compound 7 reacted with other mole of malononitrile and furnished thiazolo [3,2-a] pyridine 12, furthermore, compound 7 refluxed with phenyl hydrazine, thiourea, and formic acid, to form the corresponding thiazolo [3,2-a] pyridines 13, 15 and 17, respectively. Also, compound 1 reacted with phNCS in presence of KOH and afforded 19. The molecular modeling of the synthesized compounds has been drawn and their molecular parameters were calculated. Also, valuable information is obtained from calculation of the molecular parameters including electronegativity, net dipole moment of the compounds, total energy, electronic energy, binding energy, electrophilicity index, HOMO and LUMO energy.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science(boys), Al-Azhar University, Nasr City, Cairo, Egypt

    G. A. M. Elhagali & R. A. Eliswey

  2. Chemistry Department, Faculty of Science, Ain Shams, Cairo, Egypt

    G. A. Elsayed

  3. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

    A. A. El-Sherif

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  1. G. A. M. Elhagali
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  2. G. A. Elsayed
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  3. R. A. Eliswey
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  4. A. A. El-Sherif
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Correspondence to G. A. M. Elhagali.

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Elhagali, G.A.M., Elsayed, G.A., Eliswey, R.A. et al. Molecular modeling and cyclization reactions of 2-(4-oxothiazolidine-2-ylidene) acetonitrile. J IRAN CHEM SOC 15, 1243–1254 (2018). https://doi.org/10.1007/s13738-018-1322-2

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