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Incorporation of graphene oxide–NiO nanocomposite and n-hexyl-3-methylimidazolium hexafluoro phosphate into carbon paste electrode: application as an electrochemical sensor for simultaneous determination of benserazide, levodopa and tryptophan

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Abstract

The benserazide (BZ) and levodopa (LD) are two important catechol drugs to inhibit dopamine production outside the brain. On the other hand, BZ is effective on tryptophan (Trp) metabolism as an inhibitor aromatic amino acid decarboxylase. A voltammetric sensor based on carbon paste electrodes modified with graphene oxide–NiO nanocomposite and n-hexyl-3-methylimidazolium hexafluoro phosphate (n-H-3MIHF) as a binder is proposed to detect and quantify of BZ, LD and Trp in drug and urine samples. In square-wave voltammetry technique, BZ, LD and Trp were given sensitive oxidation peaks at 156, 312 and 740 mV, respectively. At a best electrochemical conditions, the enhanced oxidation peak currents represented the excellent analytical performance of simultaneous detection of BZ, LD and Trp in the ranges of 0.1–600, 0.1–700 and 5.0–700 μM, with a low limit of detection of 0.05 μM for BZ, 0.05 for LD and 1.0 μM for Trp (S/N = 3), respectively. To further validate its possible application, the proposed sensor was successfully used for the determination of above compounds in tablet and urine with satisfactory results.

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References

  1. W.W. He, X.W. Zhou, J.Q. Lu, Chin. Chem. Lett. 18(1), 91–93 (2007)

    Article  CAS  Google Scholar 

  2. C. Zapata-Urzúa, M. Pérez-Ortiz, M. Bravo, A. Olivieri, A. Álvarez-Lueje, Talanta 82(3), 962–968 (2010)

    Article  Google Scholar 

  3. A.-B. Badawy, S. Bano, A. Steptoe, Alcoh. Alcoholism 46(6), 661–671 (2011)

    Article  CAS  Google Scholar 

  4. P.A. Johansen, W.A. Wolf, D.M. Kuhn, Biochem. Pharm. 41(4), 625–628 (1991)

    Article  CAS  Google Scholar 

  5. M.M. Yust, J. Pedroche, J. Girón-Calle, J. Vioque, F. Millán, M. Alaiz, Food Chem. 85(2), 317–320 (2004)

    Article  CAS  Google Scholar 

  6. M. Doležalová, M. Tkaczykova, J. Pharm. Biomed. Anal. 19(3), 555–567 (1999)

    Article  Google Scholar 

  7. J. Coello, S. Maspoch, N. Villegas, Talanta 53(3), 627–637 (2000)

    Article  CAS  Google Scholar 

  8. I. Molnár-Perl, M. Pintér-Szakács, Anal. Biochem. 177(1), 16–19 (1989)

    Article  Google Scholar 

  9. M. Pistonesi, M.E. Centurión, B.S.F. Band, P.C. Damiani, A.C. Olivieri, J. Pharm. Biomed. Anal. 36(3), 541–547 (2004)

    Article  CAS  Google Scholar 

  10. H. Yaghoubian, H. Karimi-Maleh, M.A. Khalilzadeh, F. Karimi, Int. J. Electrochem. Sci. 4(7), 993–1003 (2009)

    Google Scholar 

  11. M. Fouladgar, H. Karimi-Maleh, V.K. Gupta, J. Mol. Liq. 208, 78–83 (2015)

    Article  CAS  Google Scholar 

  12. A.A. Ensafi, H. Bahrami, B. Rezaei, H. Karimi-Maleh, Mater. Sci. Eng., C 33(2), 831–835 (2013)

    Article  CAS  Google Scholar 

  13. J.B. Raoof, R. Ojani, H. Karimi-Maleh, Electroanalysis 20(11), 1259–1262 (2008)

    Article  CAS  Google Scholar 

  14. M. Naushad, V. Gupta, S. Wabaidur, Z. Alothman, Int. J. Electrochem. Sci. 8, 297 (2013)

    CAS  Google Scholar 

  15. E. Dinç, Ş. Demircan, S. Altinöz, Rev. Anal. Chem. 28(2), 137–149 (2009)

    Article  Google Scholar 

  16. H. Karimi-Maleh, F. Tahernejad-Javazmi, A.A. Ensafi, R. Moradi, S. Mallakpour, H. Beitollahi, Biosens. Bioelectr. 60, 1–7 (2014)

    Article  CAS  Google Scholar 

  17. B.J. Sanghavi, O.S. Wolfbeis, T. Hirsch, N.S. Swami, Microchim. Acta 182(1–2), 1–41 (2015)

    Article  CAS  Google Scholar 

  18. R.W. Murray, J.B. Goodenough, W.J. Albery, Philos. Trans. R. Soc. B 302, 264–265 (1981)

    Google Scholar 

  19. A. Abo-Hamad, M.A. AlSaadi, M. Hayyan, I. Juneidi, M.A. Hashim, Microchim. Acta 193, 321–343 (2016)

    CAS  Google Scholar 

  20. R. Bavandpour, H. Karimi-Maleh, M. Asif, V.K. Gupta, N. Atar, M. Abbasghorbani, J. Mol. Liq. 213, 369–373 (2016)

    Article  CAS  Google Scholar 

  21. S. Cheraghi, M.A. Taher, H. Karimi-Maleh, Electroanalysis 28, 366–371 (2015)

    Article  Google Scholar 

  22. H. Karimi-Maleh, A. FallahShojaei, K. Tabatabaeian, F. Karimi, S. Shakeri, R. Moradi, Biosens. Bioelect. 86, 879–884 (2016)

    Article  CAS  Google Scholar 

  23. H. Karimi-Maleh, M. Hatami, R. Moradi, M.A. Khalilzadeh, S. Amiri, H. Sadeghifar, Microchim. Acta 183, 2957–2964 (2016)

    Article  CAS  Google Scholar 

  24. B. Unnikrishnan, Y.-L. Yang, S.-M. Chen, Int. J. Electrochem. Sci. 6, 3224–3237 (2011)

    CAS  Google Scholar 

  25. A. Safavi, N. Maleki, F. Farjami, E. Farjami, J. Electroanal. Chem. 626(1), 75–79 (2009)

    Article  CAS  Google Scholar 

  26. G. Absalan, M. Akhond, A. Bananejad, H. Ershadifar, J. Iran. Chem. Soc. 12(7), 1293–1301 (2015)

    Article  CAS  Google Scholar 

  27. S. Momeni, M. Farrokhnia, S. Karimi, I. Nabipour, J. Iran. Chem. Soc. 13(6), 1027–1035 (2016)

    Article  CAS  Google Scholar 

  28. W. Wang, X. Li, X. Yu, L. Yan, B. Lei, P. Li, C. Chen, W. Sun, J. Iran. Chem. Soc. 13(2), 323–330 (2016)

    Article  CAS  Google Scholar 

  29. M. Shabani-Nooshabadi, M. Roostaee, J. Mol. Liq. 220, 329–333 (2016)

    Article  CAS  Google Scholar 

  30. F.-H. Wu, G.-C. Zhao, X.-W. Wei, Z.-S. Yang, Microchim. Acta 144(4), 243–247 (2004)

    Article  CAS  Google Scholar 

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Acknowledgements

The authors are grateful to University of Kashan for supporting this work by Grant No (434066-13).

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Islamic Republic of Iran

    Mehdi Shabani-Nooshabadi

  2. Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Islamic Republic of Iran

    Mehdi Shabani-Nooshabadi & Maryam Roostaee

  3. Department of Chemistry, Graduate University of Advanced Technology, Kerman, Islamic Republic of Iran

    Hassan Karimi-Maleh

Authors
  1. Mehdi Shabani-Nooshabadi
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  2. Maryam Roostaee
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  3. Hassan Karimi-Maleh
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Correspondence to Mehdi Shabani-Nooshabadi or Hassan Karimi-Maleh.

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Shabani-Nooshabadi, M., Roostaee, M. & Karimi-Maleh, H. Incorporation of graphene oxide–NiO nanocomposite and n-hexyl-3-methylimidazolium hexafluoro phosphate into carbon paste electrode: application as an electrochemical sensor for simultaneous determination of benserazide, levodopa and tryptophan. J IRAN CHEM SOC 14, 955–961 (2017). https://doi.org/10.1007/s13738-016-1045-1

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