Abstract
Gold-198 nanoparticles (198AuNPs) can be engineered with precise size, shape, composition, surface chemistry, radioactivity and radionuclide purity for clinical applications in nuclear medicine. In the present work, chitosan-capped AuNPs were prepared by exposing HAuCl4 to acidic chitosan solution under appropriate conditions and then irradiated in Tehran Research Reactor (TRR). After that, UV–Vis spectroscopy, FTIR, SEM and DLS were used for irradiated and non-irradiated sample characterization. FTIR studies were performed for controlling radiation-induced degradation of AuNPs@chitosan. From these results, it is concluded that the chemical bonds and backbone structure of chitosan does not change after the irradiation in a neutron flux of 3 × 1012 n cm−2 s−1 for 30 min. The SEM photograph clearly indicated that gold nanoparticles were spherical with an average size of ~62 and 63 nm before and after neutron irradiation, respectively. So, there was no significant difference in the size of irradiated and non-irradiated nanoparticles. 198AuNPs@chitosan with high radionuclide purity produced using the epithermal neutron-capture reaction, 197Au (n, γ) 198Au, are especially useful for cancer treatment and imaging.
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B.I. Kharisov, O.V. Kharissova, S.S. Berdonosov, Rec. Patents Nanotech. 8, 1 (2014)
V. Bouchat, V.E. Nuttens, C. Michiels, B. Masereel, O. Feron, B. Gallez, T. Vander Borght, S. Lucas, Med. Phys. 37, 1826 (2010)
L. Zhang, H. Chen, L. Wang, T. Liu, J. Yeh, G. Lu, L. Yang, H. Mao, Nanotechnol. Sci. Appl. 3, 159 (2010)
A.W. Ajlouni, J. Mater. Sci. Eng. 4, 12 (2010)
C.S. Cutler, H.M. Hennkens, N. Sisay, S. Huclier-Markai, S.S. Jurisson, Chem. Rev. 113, 858 (2013)
A.K. Khan, R. Rashid, G. Murtaza, A. Zahra, Trop. J. Pharma. Res. 13, 1169 (2014)
M.Y. Spivak, R.V. Bubnov, I.M. Yemets, L.M. Lazarenko, N.O. Tymoshok, Z.R. Ulberg, EPMA J. 4, 18 (2013)
R. Shukla, V. Bansal, M. Chaudhary, A. Basu, R. Bhonde, M. Sastry, Langmuir 21, 10644 (2005)
H.M. Joshi, D.R. Bhumkar, K. Joshi, V. Pokharkar, M. Sastry, Langmuir 22, 300 (2006)
C. Louis, O. Pluchery, Gold nanoparticles for physics, chemistry and biology (Imperial College Press, London, 2012)
S.M. Axiak-Bechtel, A. Upendran, J.C. Lattimer, J. Kelsey, C.S. Culter, K.A. Selting, J.N. Bryan, C.J. Henry, E. Boote, D.J. Tate, M.E. Bryan, K.V. Katti, R. Kannan, Int. J. Nanomed. 9, 5001 (2014)
N. Chanda, P. Kan, L.D. Watkinson, R. Shukla, A. Zambre, T.L. Carmack, H. Engelbrecht, J.R. Lever, K. Katti, G.M. Fent, S.W. Casteel, C.J. Smith, W.H. Miller, S. Jurisson, E. Boote, J.D. Robertson, C. Cutler, M. Dobrovolskaia, R. Kannan, K.V. Katti, Nanomed. 6, 201 (2010)
F.S. Lin, C.H. Chen, F.G. Tseng, Y. Hwu, J.K. Chen, S.Y. Lin, C.S. Yang, Int. J. Mater. Mech. Manufact. 1, 265 (2013)
R. Kannan, A. Zambre, N. Chanda, R. Kulkarni, R. Shukla, K. Katti, A. Upendran, C. Cutler, E. Boote, K.V. Katti, WIREs Nanomed. Nanobiotechnol. 4, 42 (2012)
M.K. Khan, L.D. Minc, S.S. Nigavekar, M.S.T. Kariapper, B.M. Nair, M. Schipper, A.C. Cook, W.G. Lesniak, L.P. Balogh, Nanomed. NBM. 4, 57 (2008)
M. Mahmoudi, A. Simchia, M. Iman, J. Iran. Chem. Soc. 7, 1 (2010)
D.R. Bhumkar, H.M. Joshi, M. Sastry, V.B. Pokharkar, Pharm. Res. 24, 1415 (2007)
S.C. Boca, M. Potara, F. Toderas, O. Stephan, P.L. Baldeck, S. Astilean, Mater. Sci. Eng. C 31, 184 (2011)
C.R. Dass, P.F.M. Choong, J. Microencaps. 25, 275 (2008)
V.K. Lakshmanan, K.S. Snima, J.D. Bumgardner, S.V. Nair, R. Jayakumar, Adv. Polymer Sci. 243, 55 (2011)
International Atomic Energy Agency. Controlling of Degradation Effects in Radiation Processing of Polymers. IAEA-TECDOC-1617, Vienna, Austria (2009)
V.S. Ivanov, Radiation chemistry of polymers (new concepts in polymer science), 1st edn. (Brill Academic, Netherlands, 1992)
L.Y. Lim, E. Khor, O. Koo, J. Biomed. Mater. Res. 43, 282 (1998)
H. Huang, Q. Yuan, X. Yang, Colloids Surf. B. Biointer. 39, 31 (2004)
H. Huang, Q. Yuan, X. Yang, J. Colloid Interface Sci. 282, 26 (2005)
S. Malathi, M.D. Balakumaran, P.T. Kalaichelvan, S. Balasubramanian, Adv. Mat. Lett. 4, 933 (2013)
Y. Wu, F. Zuo, Y. Lin, Y. Zhou, Z. Zheng, X. Ding, J. Macromol. Sci., Pure Appl. Chem. 51, 441 (2014)
D. Wei, W. Qian, Colloids Surf. B. Biointerfaces. 62, 136 (2008)
A. Komalam, L.G. Muraleegharan, S. Subburaj, S. Suseela, A. Babu, S. George, Int. Nano Lett. 2012(2), 26 (2012)
C. Sun, R. Qu, H. Chen, C. Ji, C. Wang, Y. Sun, B. Wang, Carbohydr. Res. 343, 2595 (2008)
H. Huang, X. Yang, Carbohydr. Res. 339, 2627 (2004)
S. Panigrahi, S. Basu, S. Praharaj, S. Pande, S. Jana, A. Pal, S.K. Ghosh, T.J. Pal, Phys. Chem. C 111, 4596 (2007)
D. Rezaei Ochbelagh, S. Sohrabnezhad, M. Kashefi Biroon, N. Morsali Golboos, Spectrchim. Acta. A 92, 245 (2012)
S. Sohrabnezhad, D. Rezaei Ochbelgh, N. Morsali Golboos, Int. J. Nanosci. 9, 61 (2013)
F. Sonvico, M.T. Di Barib, L. Bovec, A. Deriub, F. Cavatortab, G. Albanese, Phys. B 385–386, 725 (2006)
J. Lim, S.P. Yeap, S.C. Low, Nanoscale Res. Lett. 8, 381 (2013)
F. Molaabasi, S. Hosseinkhani, A.A. Moosavi-Movahedi, M. Shamsipur, RSC ADV. 5, 33123 (2015)
A. Majzik, R. Patakfalvi, V. Hornok, I. Dekany, Gold Bull. 42, 113 (2009)
S. Honary, F. Zahir, Trop. J. Pharm. Res. 12, 265 (2013)
Z. Prouza, M. Rakovic, Chem. Papers 22, 87 (1968)
B. Abdullahi, M.T. Tsepav, Int. J. Sci. Tech. 2, 281 (2012)
K.M. Case, F. de Hoffmann, G. Placzek, Introduction to the theory of neutron diffusion I, 17 (Los Alamos, New Mexico, 1953)
G. Steinhauser, S. Merz, F. Stadlbauer, P. Kregsamer, C. Streli, M. Villa, Gold Bull. 45, 17 (2012)
Walker LS, An Overview of Current and Propose Radioactive Nanoparticle Creation and Use, 53rd Annual Meeting of the Health Physics Society, American Conference of Radiological Safety, 2008
Acknowledgments
This study was sponsored by the Nuclear Science and Technology Research Institute (Tehran, Iran). We wish to acknowledge the co-operation and the essential help of the Tehran Research Reactor Department for the competent advice and the technical support in the definition of the project.
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Aboudzadeh, M.R., Moassesi, M.E., Amiri, M. et al. Preparation and characterization of chitosan-capped radioactive gold nanoparticles: neutron irradiation impact on structural properties. J IRAN CHEM SOC 13, 339–345 (2016). https://doi.org/10.1007/s13738-015-0742-5
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DOI: https://doi.org/10.1007/s13738-015-0742-5