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Aluminium nitride catalyzed solvent-free synthesis of some novel biologically active α-aminophosphonates

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Abstract

A green and atom-efficient one-pot protocol for the synthesis of some novel α-aminophosphonates using micron-particulate AlN/Al as a new reusable heterogeneous catalyst by the Kabachnik–Fields reaction under solvent-free conditions has been developed. The synthesized α-aminophosphonates were screened for several biological activities. They all were investigated to exhibit moderate to promising antioxidant, anti-inflammatory and cytotoxic properties.

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Acknowledgments

One of the authors (SUT) sincerely thanks University Grants Commission for sanctioning a Minor Research Project [47-283/12(WRO)].

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Authors and Affiliations

  1. Department of Chemistry, Shri Muktanand College, Gangapur, MS, 431 109, India

    S. U. Tekale

  2. Department of Chemistry, Deogiri College, Station Road, Aurangabad, MS, 431 005, India

    S. S. Kauthale & R. P. Pawar

  3. School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded, MS, 431 606, India

    R. U. Shaikh

  4. Government College of Pharmacy, Aurangabad, MS, 431 005, India

    R. P. Marathe & R. B. Nawale

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  1. S. U. Tekale
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  2. S. S. Kauthale
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  3. R. U. Shaikh
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  4. R. P. Marathe
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  5. R. B. Nawale
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  6. R. P. Pawar
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Correspondence to R. P. Pawar.

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Tekale, S.U., Kauthale, S.S., Shaikh, R.U. et al. Aluminium nitride catalyzed solvent-free synthesis of some novel biologically active α-aminophosphonates. J IRAN CHEM SOC 11, 717–724 (2014). https://doi.org/10.1007/s13738-013-0344-z

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  • DOI: https://doi.org/10.1007/s13738-013-0344-z

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