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Application of PDMS-based coating in drug delivery systems using PVP as channeling agent

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Abstract

PDMS derivatives have been extensively used as coating in controlled drug delivery systems in pharmaceutical area. The major advantages of these materials are facilitation of adjustment of desired drug release patterns, improvement of film formation and storage stability. In this study PDMS-based coating systems were designed and applied to acetaminophen tablets and their release was investigated from the PDMS-coated tablet dosage form as a drug model. Thus, a water emulsion of PDMS containing tetraethoxysilane as cross-linking agent and polyvinylpyrrolidone (PVP) as channeling agent was prepared. Then, a uniform smooth thin coating of PDMS was applied on acetaminophen tablets and in vitro acetaminophen release from PDMS-coated tablets was carried out with a homemade setup. The morphology of the coated surfaces was studied by SEM technique. The effect of PVP on the mechanical properties of PDMS film was investigated by dynamic mechanical analysis. It was found that, PVP increased the mechanical properties of PDMS. Compounding of polyethylene glycol (PEG) with PVP (1:1) as channeling agents was also studied and compared with PVPs-containing samples. Despite more channeling agent content in PEG–PVP samples, the drug release percentage was decreased.

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Acknowledgments

The financial support from Iran National Science Foundation (Grant No. 87041557) is gratefully acknowledged.

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Authors and Affiliations

  1. Iran Polymer and Petrochemical Institute, P.O. Box: 14965-115, Tehran, Iran

    Hanie Soroory, Arezou Mashak & Azam Rahimi

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  1. Hanie Soroory
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  2. Arezou Mashak
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  3. Azam Rahimi
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Correspondence to Azam Rahimi.

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Soroory, H., Mashak, A. & Rahimi, A. Application of PDMS-based coating in drug delivery systems using PVP as channeling agent. Iran Polym J 22, 791–797 (2013). https://doi.org/10.1007/s13726-013-0178-7

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  • DOI: https://doi.org/10.1007/s13726-013-0178-7

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