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Identification of vital regulatory genes with network pathways among Huntington’s, Parkinson’s, and Alzheimer’s diseases

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Abstract

In the world, Huntington’s disease, Parkinson’s disease, and Alzheimer’s disease are reported as the most deadly diseases to issue common disorders for human beings. In state-of-the-art works, it is well studied that Huntington’s disease (HD) and Parkinson’s disease (PD) are affected by genetic factors and common motor system disorder, respectively. On the other hand, Alzheimer’s disease (AD) is a neurodegenerative disorder which is categorized by age-related dementia, behavioral changes, and memory loss, etc. In the literature, it is also identified that lots of similar genetic factors are interrelated among these diseases. In this paper, our key objective is to screen out the most significant common gene targets among HD, PD, and AD diseases. Here, the analysis attempts to discover efficient drug design for reactive genes by analyzing the topological properties of protein–protein interaction (PPI) networks. Initially, the analysis is started by reducing the number of total reactive genes (around 37 common genes) through preprocessing and cross-linkage. Afterward, we have identified five most significant hub proteins among these three diseases based on degree value. Moreover, a gene regulatory network has been designed to explain molecular mechanisms that significantly help to discover drugs for targeted genes.

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Acknowledgements

This manuscript has not been published yet and not even under consideration for publication elsewhere. The authors are grateful who have participated in this research work.

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Authors and Affiliations

  1. Department of Software Engineering, Daffodil International University, Sukrabad, Dhanmondi, Dhaka, Bangladesh

    Md. Kawsar, Tasnimul Alam Taz, Bikash Kumar Paul & Touhid Bhuyian

  2. Department of Information and Communication Technology (ICT), Mawlana Bhashani Science and Technology University (MBSTU), Santosh, Tangail, 1902, Bangladesh

    Bikash Kumar Paul, Kawsar Ahmed & Md. Ahsan Habib

  3. Group of Bio-photomatiχ, Mawlana Bhashani Science and Technology University (MBSTU), Santosh, Tangail, 1902, Bangladesh

    Bikash Kumar Paul & Kawsar Ahmed

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  1. Md. Kawsar
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  2. Tasnimul Alam Taz
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  3. Bikash Kumar Paul
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  4. Kawsar Ahmed
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Correspondence to Kawsar Ahmed.

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Kawsar, M., Taz, T.A., Paul, B.K. et al. Identification of vital regulatory genes with network pathways among Huntington’s, Parkinson’s, and Alzheimer’s diseases. Netw Model Anal Health Inform Bioinforma 9, 50 (2020). https://doi.org/10.1007/s13721-020-00257-4

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  • DOI: https://doi.org/10.1007/s13721-020-00257-4

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