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Molecular modeling and phylogenetic analysis of Esx homeobox-1 protein of Bubalus bubalis

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Abstract

ESX-1 is an X-linked gene, which encodes for a homeobox protein. The ESX-1 expressed specifically in extra-embryonic tissues during development and in the adult testis as well. In the present study, we have predicted the three-dimensional structure of ESX-1 homeobox protein of Bubalus bubalis using homology modeling. The predicted model further explored for identification of ligand binding sites, which may be useful for understanding specific role in functional site residues during catalysis. This study also demonstrated the phylogenetic analysis of ESX-1 homeobox protein of B. bubalis with different similar species. The ESX-1 homeobox protein of B. bubalis has shown similarity with Bos taurus, Ovis aries and Capra hircus species.

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Acknowledgments

We appreciate reviewers valuable suggestions and comments.

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Authors and Affiliations

  1. Center of Bioinformatics, University of Allahabad, Allahabad, India

    Pooja Tripathi & Vijay Tripathi

  2. Department of Biochemistry, Indian Veterinary Research Institute, Bareilly, India

    Brijesh Singh Yadav

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  1. Pooja Tripathi
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  2. Brijesh Singh Yadav
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  3. Vijay Tripathi
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Correspondence to Vijay Tripathi.

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Tripathi, P., Yadav, B.S. & Tripathi, V. Molecular modeling and phylogenetic analysis of Esx homeobox-1 protein of Bubalus bubalis . Netw Model Anal Health Inform Bioinforma 3, 57 (2014). https://doi.org/10.1007/s13721-014-0057-y

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  • DOI: https://doi.org/10.1007/s13721-014-0057-y

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