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Recognition and Management of Toxic Erythema of Chemotherapy for the Inpatient Dermatologist

  • Hospital-Based Dermatology (L Guggina and C Nguyen, Section Editors)
  • Published:
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Abstract

Purpose of Review

Toxic erythema of chemotherapy is an umbrella term for several non-allergic cutaneous reactions to chemotherapeutic agents. Given the heterogenous range of presentations, we will review the differential diagnoses and treatment approaches, particularly for hospitalized patients.

Recent Findings

Early recognition, holding chemotherapy, or dose reduction and monitoring fluid balance for severely ill patients is the mainstay of treatment. Supportive care with topical steroids, emollients, and wound care have shown benefit.

Summary

Toxic erythema of chemotherapy can mimic several common eruptions seen in oncologic patients. The recognition of both clinical and pathological features by inpatient dermatologists allows for appropriate management, and dose reduction if necessary, in order for patients to continue oncologic treatment.

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Authors and Affiliations

  1. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Nari Lee

  2. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Lida Zheng

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  1. Nari Lee
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  2. Lida Zheng
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Correspondence to Lida Zheng.

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Lee, N., Zheng, L. Recognition and Management of Toxic Erythema of Chemotherapy for the Inpatient Dermatologist. Curr Derm Rep 10, 222–231 (2021). https://doi.org/10.1007/s13671-021-00344-3

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