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The Skin Microbiome in Inflammatory Skin Diseases

  • Infectious Disease and Dermatology (C Beard and K Krishnamurthy, SECTION EDITORS)
  • Published:
Current Dermatology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Ongoing investigations of the human skin microbiome strongly suggest a connection to skin diseases and skin health. This review provides an overview of recent literature on the skin microbiome in relation to skin diseases, with a specific focus on common inflammatory skin conditions, such as atopic dermatitis, psoriasis, hidradenitis suppurativa, acne, and rosacea.

Recent Findings

In healthy subjects, the skin microbiome mediates fundamental processes involving the immune response and epidermal development and differentiation. Microbiome characteristics in inflammatory skin diseases differ depending on disease, as both topography and disease severity and even host genetics seem to influence the microbiome composition. Not only the bacterial species are important but also different strains within the same species can act differently, where some can be commensal and protect against microbial dysbiosis, whereas others can induce skin inflammation and immune reactions in humans.

Summary

The interplay between skin microbes, host genetics, and the immune system is anticipated to be of importance for both the development and severity of many skin diseases. However, the causality of specific pathogens and the effect on the pathogenesis in relation to inflammatory skin diseases is yet to be understood.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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  1. Department of Dermatology, Bispebjerg Hospital, University Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, NV, Denmark

    Line Brok Nørreslet, Tove Agner & Maja-Lisa Clausen

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  1. Line Brok Nørreslet
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  3. Maja-Lisa Clausen
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Correspondence to Line Brok Nørreslet.

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Nørreslet, L.B., Agner, T. & Clausen, ML. The Skin Microbiome in Inflammatory Skin Diseases. Curr Derm Rep 9, 141–151 (2020). https://doi.org/10.1007/s13671-020-00297-z

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