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Resveratrol and Cardiovascular Disease

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Abstract

Resveratrol, a phytoalexin and antioxidant polyphenol found in red wine and various plants, is a promising therapeutic compound. Experimental evidence suggests that resveratrol might exert beneficial effects for the prevention of cardiovascular diseases, ischemic injuries, obesity, diabetes, inflammation, and so on. However, the molecular mechanisms underlying the beneficial effects of resveratrol remain to be determined. Here, we provide a review of the studies on resveratrol, especially with respect to cyclooxygenase (COX), peroxisome proliferator-activated receptor (PPAR), and endothelial nitric oxide synthase (eNOS), and discuss their association with reduced risk for cardiovascular disease.

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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research (No. 24300217) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Iijima Memorial Foundation for the Promotion of Food Science and Technology, Japan Food Chemical Research Foundation, and the Kieikai Research Foundation.

This article was reviewed by Dr. Julia H. Goedecke of the University of Cape Town (South Africa).

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Rieko Nakata and Hiroyasu Inoue declare that they have no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Department of Food Science and Nutrition, Nara Women’s University, Kitauoya-nishimachi, Nara, 630-8506, Japan

    Rieko Nakata & Hiroyasu Inoue

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  1. Rieko Nakata
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Correspondence to Hiroyasu Inoue.

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Nakata, R., Inoue, H. Resveratrol and Cardiovascular Disease. Curr Nutr Rep 3, 163–169 (2014). https://doi.org/10.1007/s13668-014-0084-4

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