Minoxidil Topical Solution USP 5% (w/v)
Mintop Forte 5% Solution is a medicinal drug used in the cure of male pattern baldness. It is the highest quality in treating familial hair loss or thinning at the top of the scalp, no longer in front. Mintop Forte 5% Solution helps to stimulate hair increase with the aid of growing the blood circulation to the hair follicles. However, the amount of hair growth is one-of-a-kind for every person. During the first 2 weeks of application, your hair fall may extend temporarily. This is every day and is a sign that the remedy is working. This medicine must strictly be taken following the doctor’s advice in Table 11.
Table 11 Minoxidil topical solution USP 5% (w/v) Mechanism of Action
Minoxidil is a vasodilator it widens the blood vessels which improves blood flow. Using Mintop solution on the top of scalp increase the blood flow which provides more the oxygen and nutrient to the hair follicle that lower the death of hair follicle cell. This medication triggered the anagen chemical messenger.
Expert Comments
Should be applied directly to the scalp area. If it comes in contact with eyes and mouth immediately wash with cool water properly. Do not use a hairdryer as it reduces effectiveness. Do not apply shampoo for 4 h after applying the Mintop Forte solution. Use carefully because in contact with face it will cause unwanted facial hair growth.
Some of the alternative brands for Mintop Forte Solution have been described in Table 12 with their; brand name, the composition of salt, type of dosage form, name of the manufacturer, and the volume of the dosage form.
Table 12 Alternative brands for Mintop Forte solution Men’s Rogaine 2%, 5% Aerosol (Easy to Use Foam)
Aerosol helps in hair growth when applied to the vertex part. Outline of this aerosol is described in Table 13 which includes ingredients that are used in this aerosol, type of dosage form, use of aerosol, what are storage conditions, and inactive ingredients used. Some of the drawbacks of this aerosol include; chest pain, rapid heartbeat, dizziness, increase in body weight, irritation on the scalp, undesired facial hair growth, no improvement after applying for 4 months.
Table 13 Men’s Rogaine 2%, 5% aerosol (easy to use foam) Precautions that one should be kept in mind include; only for external use; away for children; as it is in aerosol so it is extremely flammable.
EquateTM
EquateTM which is Minoxidil 2%, 5% topical solution which contains alcohol, propylene glycol, purified water as inactive ingredients. It should be used only for the vertex portion; only for male baldness and applied two times a day directly to the scalp. It is contraindicated in the case of women’s baldness. As it contains alcohol so chances of fire are more; keep away for the flame as well as fire.
Some of the information about Minoxidil 2%, a 5% solution is given in CIMS. Information is elaborated in Table 14 that covers male and female adults, safety measures, contraindication as well as interaction and adverse drug reaction.
Table 14 Minoxidil 2%, 5% solution (CIMS data) Inoxi 10% Solution
Inoxi 10% solution is commonly used for the treatment of hair growth and only male pattern baldness and effective treatment for hereditary hair loss; thinning of hair at the top of the scalp, not the front. This solution is manufactured by Psycoremedies which has 10% Minoxidil.
Mechanism of Action
Increasing blood circulation to hair follicles. That to leads more oxygen supply to hair follicles and leads to less death of hair scalp cells. During 1st 2 weeks of application, hair fall may increase temporarily this is a normal sign of medicine effectiveness.
Other available brands include; Morr 10% solution manufactured by Intas Pharmaceuticals; Grewit 10% solution manufactured by Kivi Labs Ltd.; Trichoton M 10% solution manufactured by Med Manor Organics Pvt. Ltd.
This solution is unsafe for women and children.
The Topical solution is available in 20 mg/60 mL which costs about Rs. 153.00 and 100 mg/60 mL which costs about Rs. 550.00.
Inoxi Forte
Inoxi Forte which is 5% Minoxidil lotion manufactured by Psycoremedies and its mechanism of action includes widening blood vessels and opening potassium channel.
Uses
This lotion is used for the; Hair growth stimulation; Androgenic alopecia; Hereditary hair loss problems.
Supportive Measures
5% Minoxidil lotion has interaction with other drugs those include; Clonidine, Nadolol, Nicorandil, Propranolol, Tretinoin.
Side effects of this lotion comprise of increase in heart rate; chest pain; tenderness in the breast; rare palpitations.
The lotion is opposed in cases like hypersensitivity; angina pectrosis; pregnancy.
It must be stored at room temperature. Don’t freeze this lotion.
Apply only to scalp; avoid contact with eyes and mucous membrane.
Minch
Minch containing about Minoxidil 3% and Minoxidil 12.5% (w/v) manufactured by Aamorb (Sioux) having volume 60 mL.
It is used to treat male pattern baldness only on the top of the scalp, not in front. It works by increasing the blood circulation, oxygen supply, and nutrition to the hair follicles. During the first 2 weeks of hair fall may enhance for a time that means medicine has shown effective results.
Expert Advice
Apply directly to the scalp, do not shampoo for 4 h after applying the medication, during first 2 weeks hair fall may increase.
Supportive Measures
Side effects include; irritation at the applied site; itching; headache.
Unsafe During Pregnancy
Other brands available for this include; more 3% solution by Intas Pharmaceuticals Ltd.; MNX-3 topical solution by Salve Pharmaceuticals Ltd.
If you have missed the dose take as soon as possible if it is too late then following the next day schedule but not double the dose.
Radixil
Radixil is a topical solution of Minoxidil 2%, 5% and 10% manufactured by Signova Pharma Pvt. Ltd. Several side effects include; irregularity in a heartbeat; an increase in weight; shortness of breath; skin redness; irritation in the eye.
Different drug interactions with Radixil; Alprazolam; Corticosteroids; Guanethidine.
A substitute available includes Exidil 5%, Morr 5%, Rootz 5%, Tugain 5%.
Pilogro
Pilogro is a topical 2%, 5% Minoxidil manufactured by Fulford. Its onset of action can be observed within 4–5 h after application and may cause sleepiness.
Side effects of this include; shortness of breath; chest pain; weight gain; an irregular heartbeat.
Contraindicated in patients with congestive heart failure, unsafe for pregnant and breastfeeding women.
Regero
Regero, Minoxidil 2% topical solution manufactured by Shinto Organics Ltd. Having a volume of 60 mL. It is a type of vasodilator used in the treatment of male pattern baldness. Applied on the scalp directly not used for the front portion.
Side effects of this solution include; itching; headache; irritation; chest pain; unwanted hair growth to the undesired site; swollen hands and feet.
Other than these alternative brands are also available in Table 15.
Table 15 Alternative brand available for Regero Retreat
Retreat is Minoxidil 5% (w/w) topical gel manufactured by Segment Care whose volume is 60 g.
Mechanism of Action
Vasodilator expands blood vessels which promotes blood supply and provides nutrition and oxygen to hair follicles that prevent hair cell death and result in an improvement in hair growth by prolonging the action of chemical messenger anagen.
How to use: use it in the dose and duration as advised by the Doctor. Check the level for direction before using it. Clean and dry the affected area and then apply the gel. Wash hands after applying.
Some of the alternative brands include; Tugain 5% gel (Cipla Ltd.), Curlz pep gel 5% (w/v) (Canixa Life Science Pvt.), Regrowee 5% gel (w/w) (West Coast Pharmaceutical Works Ltd.), Menexil 5% gel (Dabur India Ltd.)
Stonark
Minoxidil 5% (w/v) solution manufactured by Cutis Derma. Use it in the dose as prescribed by the physician. Alternative brands available for Stonark include; Tugain 5%-Cipla Ltd. Regaine 5%-Janssen Pharma. MX-5-Hedge and Hedge Pharmaceuticals, Mintop Forte 5%-Dr. Reddy’s Laboratories. Minoqilib 5%-Galderma India Pvt. Ltd.
Ximinox
2%, 5% Minoxidil lotion manufactured by Rowan Biopharmaceuticals Pvt Ltd. Side effects of this lotion–irritation, itching, headache. Different alternative brands are available for lotion-Arodil lotion-Dr. Johns Laboratories Pvt. Ltd., AGA 1% lotion-Nidus Pharma Pvt. Ltd., Mxd 10 lotion-L Med India, Minfin 10% lotion-HBC Life Science Pvt. Ltd.
Gaine Hair
Gaine hair is a 2% topical solution manufactured by Wockhardt Ltd. composed of Aminexil and Minoxidil. Other alternative brands available Tugain 2% Solution-Cipla Ltd., MX 2 Solution.
Hegde and Hegde Pharmaceuticals and Black Crown 2% Solution-Derma joint India.
Side effects of this solution headache, allergic reaction, rashes on the skin, and chest pain.
Hair 4U
Hair 4U is lotion (60 mL) manufactured by Glenmark Pharmaceuticals which is composed of Min 2% w/v + diaminopyridine oxide 1.5% w/v, Min 5% w/diamino pyridine oxide 1.5% w/v, Min 10% w/diamino pyridine 1.5% w/v.
Hair 4U 2% Lotion and Hair 4U Spray
Hair 4U 2% lotion manufactured by Glenmark Pharmaceuticals composed of Aminoxil and Minoxidil. Side effects of headache, skin rashes, edema, and dermatitis. It cannot be used in case of allergy.
Hair 4U Spray 60 mL manufactured by Glenmark Pharmaceutical Ltd. (Grace well) and composed of Minoxidil 2%, 5%, 10% + diamino pyridine oxide 1.5% Generic-Diamino pyridine oxide.
Radixil A and Radixil F
Both the solutions are manufactured by Signova Pharma Pvt. Ltd. Composition of Radixil A includes Minoxidil 5% + diamino pyridine 1.5 and Radixil F includes Minoxidil 5% + 0.1% Finasteride. Side effects of this topical solution redness and dry skin change in hair color and texture. Keep away from children and must be stored at 15–25 °C.
Stonark-AX and Stonark-2AX Solution
Both are topical solution manufactured by Cutis Derma Care. Composition of Stonark-AX Minoxidil 2% w/w + diaminopyridine oxide 1.5% w/w and Stonark-2AX Minoxidil 2% w/v + Aminexil 1.5% w/v and alternative available brands Hairjoy 2%-solution-Torrent Pharmaceuticals.
Hairslim-F Topical Solution
Solution is lipid-based composed of Minoxidil 5% w/v + Finasteride 0.1% w/v. Adverse effects are dry skin, tingling, headache, dermatitis, erythema, dizziness. After applying to allow to dry for completely 2–4 h; hairdryer not to be used.
Keshgaine-5%
Minoxidil 5% solution manufactured by Connote Health Care. It should be applied once or twice daily and the solution must contact the scalp for at least 4 h before washing.
Regenepure Precision Minoxidil 5% Spray
Spray composed of deionized water, aloe vera gel, sodium-cocoyl isethionate, carbomer, niacin, PEG-8, hydrolyzed wheat protein, allantoin, ascorbic acid, Vit-B6, linolenic acid, ketoconazole, menthol, salicylic acid, PEG-25, lemon oil, ZnO, Polysorbate-80, Phenoxyethanol, FD, and C blue. For external use only.
Formula 82F/M
Composed of 0.25% Finasteride + 5% Minoxidil, retinoic acid, oleanolic-acid, algae extract with propylene glycol. Must be used twice a day i.e. 30 drops. The common area that includes the crown, top of the scalp, and around hair transplants are the area that can be treated with this.
Andro Block F
Formulation composed of Min 5% + Azelaic acid 12.5% + Finasteride 0.1% + Ketoconazole 2% which is manufactured by Empower Pharmacy. It should be stored at temperature 68–77°F and away from heat, moisture, and light.
Minoxidil Store Plus
Formulation composed of Min 10% + Azelaic acid 5% + Finasteride 0.1%, ethyl alcohol, propylene glycol, applied to the scalp and avoided in patients having high blood pressure. Side effects are itching, difficulty in breathing, increase in heart rate.
Regre Topical Spray
Spray composed of only 5% Minoxidil (60 mL), which is used twice a day.
MX-2 Solution
The solution is composed of Minoxidil 2% manufactured by Hedge and Hedge Pharmaceuticals. This solution used only for male patterns. Other alternative available brands includes Mintop 2%, Tugain 2%, Black crown 2%, Regaine 2%.
Coverit 5%
Minoxidil 5% belongs to Schedule H, Manufactured by Micro Labs Ltd. Side effects are skin redness, weight gain, headache, and irregular heart rate.
Warnings include during pregnancy, congestive heart failure, and breastfeeding and scalp irritation.
Drug–drug interaction includes Alprazolam-moderate, Corticosteroids-moderate, and Guanethidine-severe.
Exidil 5% Solution
The solution comprises of Minoxidil 5% which is manufactured by Ranbaxy Laboratories Ltd.
Rootz 5% Solution
A solution composed of Minoxidil 5% manufactured by Cipla Ltd.
Tinfal
Composed of Minoxidil 5% (w/v), ethanol 95% and volume is 60 mL.
Tinfal Plus
Composed of Minoxidil 5% + Aminexil 1.5%, volume 60 mL, and used on dry hair once at night time.
Lipogaine (Men)
Serum composed of Minoxidil 5% with biotinyl-tripeptide, niacin, apple polyphenol. Not use more than 1 mL of serum each time, no massage required to apply directly to the scalp in the hair loss area. Stored at temperature 10–35 °C, away from children.
Lipogaine (Women)
Composed of only Minoxidil 2% and apply 1 mL to the scalp in hair loss area, apply twice a day but at least 8 h after first applied.
Keep away from children as well as from fire.
Imxia
Composed of Minoxidil 5% which is manufactured by KLM Laboratories Pvt. Ltd.
Minokem
The spray contains Minoxidil 2%, 5% (60 mL) manufactured by Alkem Laboratories.
Severe interactions with Guanethidine and moderate with Alprazolam and Corticosteroids.
Associated side effects are weight gain, irritation in the eye, chest pain, and redness of the skin.
Minotreat
Lotion that contains Minoxidil 5% manufactured by Ikon Remedies Pvt. Ltd.
For external use only and do not show interaction with any formulation.
Available Alternative Brands
Biodens hair lotion, Minotress lotion-Prism Life Science Ltd.., Arodil Forte lotion-Dr. Johns Laboratories Pvt. Ltd., TM 5 lotion-New trimed.
Proanagen Solution
Composed of diaminopyrimidine oxide topical solution, diamino pyridine oxide 1.5% (w/v) in green apple skin extract base and Kopexil (1NCI name diaminopyrimidine oxide, trade name Aminexil) manufactured by Curatio Healthcare Pvt. Ltd.
Stored at a cool place, away from light, must be applied as instructions given by dermatologists.
Mechanism of Action of Aminexil
The mechanism of action of Aminexil and Minoxidil is only structurally related by conjecture. It prolongs the hair development phase through non-hormonal mechanisms. Furthermore, hair follicles get hardened by DHT are softened by Aminexil. It expands the blood vessels and provides better blood flow to the hair follicles. Commonly used in hair cosmetic products to fight against hair loss due to premature exhaustion of the hair root. The drug acts by stimulating or inhibiting a receptor or an enzyme or a protein most of the time. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
Mechanism of Action of Diaminopyridine (3,4-Diaminopyridine)
Blocks calcium-dependent potassium channels and prolongs the duration of the action potential at motor nerve terminals; this enhances calcium influx into nerve endings and causes the release of acetylcholine [97]. It selectively blocks presynaptic fast voltage-gated potassium channels thus prolonging cell membrane depolarization and action potential, and increasing calcium transport into the nerve endings.
Keraglo Eva
Keraglo Eva is Manufactured by Ipca Laboratories Ltd., generic uses include Biotin, Folic Acid, Selenium. Composed of Biotin (10 Mg), Folic Acid (300 Mcg), Selenium (40 Mcg) Gamma Linolenic Acid (found mostly in plant-based oils such as borrage seed oil), multivitamin, multimineral. Gamma-linolenic acid is an essential fatty acid that helps to stop hair loss, as well as the growth of hair. No side effects, have been reported at appropriate doses. Daily dosage is 1 tablet daily with a glass of water, before or after a meal.
Drug Interaction of Biotin
May Interact With Clozapine, Fluvoxamine, Haloperidol, Mexiletine, Imipramine, Olanzapine, Pentazocine, Propranolol, Tacrine, Theophylline, Zileuton, and Zolmitriptan. Carbamazepine, Phenytoin, Phenobarbital, Valproic Acid.
Drug Interaction of Folic acid
Fluorouracil, Sulphonamide, Phenytoin, Methotrexate, Sulfasalazine, Cholestyramine.
Side effects of Folic Acid
The common side effects are urge to vomit, bloating of stomach, excessive passage of wind, loss of appetite.
Drug Interaction of Selenium
Seborrheic dermatitis.
Side Effects of Selenium
Nausea, stomach upset, skin rash, acute toxicity.
Biodens Hair Lotion
Hair lotion which is manufactured by Adonis Phytoceuticals Pvt. Ltd. and having a salt composition of Minoxidil 5% (w/v).
Side Effects of Biodens Lotion
Excessive hair growth on the face, Rash, Edema (swelling), Skin irritation.
Mechanism of Action
It works by increasing blood flow to the hair follicles on the scalp, which prevents hair cell death and also enhances new hair growth. It is effective for baldness or thinning at the top of the scalp but less effective at the front or for receding hairline. Biodens hair lotion is not appropriate for sudden or inexplicable hair loss. It is considered as a safe medicine to promote hair growth after hereditary hair loss (male pattern baldness).
Applied directly to the scalp area in the amount. Clean and dry your scalp before using it.
Alternate Brands of lotion includes Hairex Lotion-Swiss Pharma Pvt. Ltd.: Minotress Lotion-Prism Life Sciences Ltd.: TM 5 Scalp Lotion-Newtrimed.