Abstract
The first total synthesis of (−)-huperzine W (1) has been achieved. Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide 2 and 2-allylpyrrolidinone 4. Evaluation of the AchE inhibition of synthetic huperzine W was also carried out.
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Xu, T., Jiang, SZ., Luo, HR. et al. One-step synthesis of Lycopodium alkaloid (-)-huperzine W via Suzuki-Miyaura coupling. Nat. Prod. Bioprospect. 2, 255–257 (2012). https://doi.org/10.1007/s13659-012-0084-2
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DOI: https://doi.org/10.1007/s13659-012-0084-2