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Michael addition-based cyclization strategy in the total synthesis of Lycopodium alkaloids

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Abstract

Lycopodium alkaloids, a unique family of biologically important natural products isolated and characterized from various species of Lycopodium (sensu lato), have attracted extensive attention from chemists and pharmacists in the past three decades. Michael addition-based cyclization has been successfully employed as an elegant and efficient ring-construction protocol of constructing key cyclohexanone intermediates in the total synthesis of Lycopodium alkaloids. This mini-review chooses and summarizes several representative total syntheses of various Lycopodium alkaloids in which intramolecular Michael addition severed as the key methodology.

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Authors and Affiliations

  1. State Key Laboratory of Coordination Chemistry, Institute of Chemical Biology and Drug Innovation, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing, 210023, China

    Lin-Rui Zhong & Zhu-Jun Yao

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  1. Lin-Rui Zhong
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  2. Zhu-Jun Yao
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Correspondence to Zhu-Jun Yao.

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Zhong, LR., Yao, ZJ. Michael addition-based cyclization strategy in the total synthesis of Lycopodium alkaloids. Sci. China Chem. 59, 1079–1087 (2016). https://doi.org/10.1007/s11426-016-0056-0

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