Abstract
Three new ent-kauranoids, isorosthornins A-C (1–3), and a new natural product, dihydroponicidin (4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Sun, H. D.; Xu, Y. L.; Jiang, B. “Diterpenoids from Isodon Species”. Science Press, Beijing, 2001.
Sun, H. D.; Huang, S. X.; Han, Q. B. Nat. Prod. Rep.2006, 23, 673–698.
Academia Sinca. “Botany of China”. Science Publishing House, Beijing, 1979.
Hu, K.; Dong, A. J.; Kobayashi, H.; Iwasaki, S.; Yao, X. S. Plant Deriv. Antimycotics2003, 525–549
Kubo, I.; Xu, Y. L.; Shimizu, K. Phytother. Res.2004, 18, 180–183
Li, G. Y.; Wang, Y. L. Yaoxue Xuebao1984, 19, 590–592
Xu, Y. L.; Li, Z. Q. Yunnan Zhiwu Yanjiu1998, 20, 97–101
Xu, Y. L.; Ma, Y. B. Phytochemistry1989, 28, 3235–3237.
Wang, X. R.; Wang, H. P.; Hu, H. P.; Sun, H. D.; Wang, S. Q.; Ueda, S.; Kuroda, Y.; Fujita, T. Phytochemistry1995, 38, 921–926
Fujita, E.; Taoka, M.; Shibuya, M.; Fujita, T.; Shingu, T., J. Chem. Soc., Perkin Trans. 11973, 2277–2281.
Hou, A. J.; Li, M. L.; Jiang, B.; Lin, Z. W.; Ji, S. Y.; Zhou, Y. P.; Sun, H. D. J. Nat. Prod.2000, 63, 599–601.
Gao, Y. H.; Wu, S. H.; Zhong, R. J.; Li, G. Y. Zhongcaoyao1996, 27, 579–580.
Gao, Y. H.; Wu, S. H.; Cheng, Y. Zhongcaoyao1999, 30, 407–409.
Monks, A.; Scudiero, D.; Skehan, P.; Shoemaker, R.; Paull, K.; Vistica, D.; Hose, C.; Langley, P. J. Natl. Cancer Inst. 1991, 83, 757–766.
Author information
Authors and Affiliations
Corresponding authors
Additional information
This article is published with open access at Springerlink.com
Electronic supplementary material
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Zhan, R., Du, X., Su, J. et al. Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii. Nat. Prod. Bioprospect. 1, 116–120 (2011). https://doi.org/10.1007/s13659-011-0031-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13659-011-0031-7