Abstract
Three new secoiridoids, swertiakoulactone (1) and swertiakosides A and B (2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus (HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion (IC50 = 1.10 mM, SI = 4.39) and HBV DNA replication (IC50 = 1.16 mM, SI = 4.12).
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He, K., Ma, YB., Geng, CA. et al. Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis. Nat. Prod. Bioprospect. 1, 48–51 (2011). https://doi.org/10.1007/s13659-011-0009-5
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DOI: https://doi.org/10.1007/s13659-011-0009-5